SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hpv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 2hpv FMN-DEPENDENT
NADH-AZOREDUCTASE
(Enterococcus
faecalis) 		5 / 12 GLU A  38
ILE A  39
ARG A  31
LEU A  27
THR A  49
 None
 1.19A 1d1gA-2hpvA:
2.5		 1d1gA-2hpvA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2hpv FMN-DEPENDENT
NADH-AZOREDUCTASE
(Enterococcus
faecalis) 		5 / 8 LEU A  23
ALA A 101
LEU A 178
GLY A 177
ASP A 176
 None
 1.50A 2yfxA-2hpvA:
undetectable		 2yfxA-2hpvA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 2hpv FMN-DEPENDENT
NADH-AZOREDUCTASE
(Enterococcus
faecalis) 		3 / 3 LYS A   8
VAL A  20
HIS A  10
 None
None
FMN  A1200 (-3.9A)
 1.00A 3tj7A-2hpvA:
undetectable		 3tj7A-2hpvA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2hpv FMN-DEPENDENT
NADH-AZOREDUCTASE
(Enterococcus
faecalis) 		5 / 11 LEU A  27
ILE A 180
ILE A 146
VAL A  99
LEU A 144
 None
 1.02A 3w67A-2hpvA:
undetectable		 3w67A-2hpvA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 2hpv FMN-DEPENDENT
NADH-AZOREDUCTASE
(Enterococcus
faecalis) 		5 / 12 VAL A  20
LEU A   4
ALA A 101
LEU A 144
PHE A 208
 None
 1.36A 4qdcA-2hpvA:
undetectable		 4qdcA-2hpvA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2hpv FMN-DEPENDENT
NADH-AZOREDUCTASE
(Enterococcus
faecalis) 		4 / 5 ILE A 100
GLY A 177
ILE A 163
LEU A 144
 None
 0.87A 5dzki-2hpvA:
undetectable
5dzkj-2hpvA:
undetectable
5dzkx-2hpvA:
undetectable		 5dzki-2hpvA:
24.35
5dzkj-2hpvA:
24.35
5dzkx-2hpvA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2hpv FMN-DEPENDENT
NADH-AZOREDUCTASE
(Enterococcus
faecalis) 		4 / 5 ILE A 100
GLY A 177
ILE A 163
LEU A 144
 None
 0.84A 5dzkd-2hpvA:
1.4
5dzkk-2hpvA:
undetectable
5dzky-2hpvA:
undetectable		 5dzkd-2hpvA:
22.18
5dzkk-2hpvA:
24.35
5dzky-2hpvA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2hpv FMN-DEPENDENT
NADH-AZOREDUCTASE
(Enterococcus
faecalis) 		4 / 4 ILE A 100
GLY A 177
ILE A 163
LEU A 144
 None
 0.90A 5dzkl-2hpvA:
undetectable
5dzkz-2hpvA:
undetectable		 5dzkl-2hpvA:
24.35
5dzkz-2hpvA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 2hpv FMN-DEPENDENT
NADH-AZOREDUCTASE
(Enterococcus
faecalis) 		4 / 8 VAL A 117
GLN A 147
ASN A 102
ILE A 100
 None
 0.90A 6hzpA-2hpvA:
undetectable		 6hzpA-2hpvA:
17.10