SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hpw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		4 / 8 SER A  66
HIS A 182
PHE A 101
VAL A  58
 None
 1.16A 1kb9A-2hpwA:
undetectable
1kb9C-2hpwA:
undetectable
1kb9D-2hpwA:
undetectable
1kb9E-2hpwA:
undetectable		 1kb9A-2hpwA:
19.11
1kb9C-2hpwA:
21.16
1kb9D-2hpwA:
22.22
1kb9E-2hpwA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		3 / 3 LYS A 127
ILE A  98
THR A  62
 None
 0.78A 1rx3A-2hpwA:
undetectable		 1rx3A-2hpwA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		5 / 12 LEU A 220
LEU A  67
SER A  65
VAL A 109
VAL A  58
 None
GYS  A  68 ( 4.2A)
None
None
None
 1.28A 2qd4A-2hpwA:
undetectable		 2qd4A-2hpwA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		4 / 5 GLU A  14
PRO A  16
ILE A  15
GLY A  38
 None
 1.13A 2qeuA-2hpwA:
undetectable
2qeuC-2hpwA:
undetectable		 2qeuA-2hpwA:
21.61
2qeuC-2hpwA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		5 / 12 LEU A  64
PHE A 101
TYR A 107
PHE A 170
HIS A 182
 None
 1.43A 2x2iA-2hpwA:
undetectable		 2x2iA-2hpwA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		4 / 5 GLN A  89
THR A  88
HIS A 200
LEU A 202
 None
 1.02A 2zj0A-2hpwA:
undetectable		 2zj0A-2hpwA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		4 / 5 GLN A  89
THR A  88
HIS A 200
LEU A 202
 None
 1.10A 3ce6A-2hpwA:
undetectable		 3ce6A-2hpwA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		4 / 5 GLN A  89
THR A  88
HIS A 200
LEU A 202
 None
 1.07A 3ce6C-2hpwA:
undetectable		 3ce6C-2hpwA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		4 / 5 GLN A  89
THR A  88
HIS A 200
LEU A 202
 None
 1.09A 3ce6D-2hpwA:
undetectable		 3ce6D-2hpwA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		3 / 3 THR A  44
VAL A 223
GLU A  14
 None
 0.61A 3v4tA-2hpwA:
undetectable
3v4tD-2hpwA:
undetectable		 3v4tA-2hpwA:
23.11
3v4tD-2hpwA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		4 / 6 GLU A 224
ILE A  45
TYR A  49
VAL A  58
 GYS  A  68 ( 3.4A)
GYS  A  68 ( 4.3A)
None
None
 1.12A 4a97I-2hpwA:
undetectable		 4a97I-2hpwA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		3 / 3 LYS A 127
ILE A  98
THR A  62
 None
 0.76A 4gh8A-2hpwA:
undetectable		 4gh8A-2hpwA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		4 / 5 GLN A  89
THR A  88
HIS A 200
LEU A 202
 None
 1.16A 4lvcA-2hpwA:
undetectable		 4lvcA-2hpwA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		4 / 5 GLN A  89
THR A  88
HIS A 200
LEU A 202
 None
 1.17A 4lvcC-2hpwA:
undetectable		 4lvcC-2hpwA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		3 / 3 ASN A 122
TYR A  17
CYH A  73
 GYS  A  68 ( 3.7A)
None
None
 0.72A 5lsuB-2hpwA:
undetectable		 5lsuB-2hpwA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		5 / 10 VAL A  58
THR A  62
ILE A  63
LEU A  21
GLY A 128
 None
 1.20A 5mxbA-2hpwA:
1.1		 5mxbA-2hpwA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		4 / 8 ALA A 180
VAL A 124
GLN A  95
HIS A 149
 None
None
GYS  A  68 ( 3.5A)
GYS  A  68 ( 3.8A)
 0.97A 5nu7A-2hpwA:
undetectable		 5nu7A-2hpwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		4 / 4 VAL A 126
VAL A 109
TYR A 107
GLN A 106
 None
 1.27A 5qggA-2hpwA:
undetectable		 5qggA-2hpwA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		4 / 4 VAL A 126
VAL A 109
TYR A 107
GLN A 106
 None
 1.27A 5qgoA-2hpwA:
undetectable		 5qgoA-2hpwA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		4 / 4 VAL A 126
VAL A 109
TYR A 107
GLN A 106
 None
 1.25A 5qgpA-2hpwA:
undetectable		 5qgpA-2hpwA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		4 / 4 VAL A 126
VAL A 109
TYR A 107
GLN A 106
 None
 1.23A 5qgqA-2hpwA:
undetectable		 5qgqA-2hpwA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		4 / 4 VAL A 126
VAL A 109
TYR A 107
GLN A 106
 None
 1.25A 5qhbA-2hpwA:
undetectable		 5qhbA-2hpwA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		4 / 8 THR A 129
GLY A 130
GLY A 105
SER A 100
 None
 0.72A 5vw9A-2hpwA:
undetectable		 5vw9A-2hpwA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		3 / 3 TYR A 199
ALA A 228
LEU A 202
 None
 0.54A 6ag0C-2hpwA:
undetectable		 6ag0C-2hpwA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_2
(-)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		4 / 4 GLN A  89
THR A  88
HIS A 200
LEU A 202
 None
 1.19A 6f3nB-2hpwA:
undetectable		 6f3nB-2hpwA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		4 / 5 GLN A  89
THR A  88
HIS A 200
LEU A 202
 None
 1.19A 6gbnA-2hpwA:
undetectable		 6gbnA-2hpwA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		4 / 5 GLN A  89
THR A  88
HIS A 200
LEU A 202
 None
 1.18A 6gbnD-2hpwA:
undetectable		 6gbnD-2hpwA:
19.82