SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hq1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2hq1 GLUCOSE/RIBITOL
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 8 THR A  46
GLY A  36
LEU A  34
SER A  40
GLY A  12
 None
 1.32A 1jhvA-2hq1A:
3.1		 1jhvA-2hq1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2hq1 GLUCOSE/RIBITOL
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 9 THR A  46
GLY A  36
LEU A  34
SER A  40
GLY A  12
 None
 1.35A 1jhyA-2hq1A:
3.2		 1jhyA-2hq1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2hq1 GLUCOSE/RIBITOL
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		3 / 4 SER A  40
GLY A  18
GLU A 217
 None
 0.67A 3raeA-2hq1A:
undetectable
3raeC-2hq1A:
3.6		 3raeA-2hq1A:
19.33
3raeC-2hq1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2hq1 GLUCOSE/RIBITOL
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 LEU A  25
GLY A 224
ILE A 140
VAL A 183
 None
 0.85A 3wriA-2hq1A:
undetectable		 3wriA-2hq1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2hq1 GLUCOSE/RIBITOL
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 LEU A  25
GLY A 224
ILE A 140
VAL A 183
 None
 0.86A 3wriB-2hq1A:
undetectable		 3wriB-2hq1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 2hq1 GLUCOSE/RIBITOL
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 LEU A 205
ILE A 208
GLY A 186
ILE A 188
 None
 0.80A 3wxoA-2hq1A:
undetectable		 3wxoA-2hq1A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2hq1 GLUCOSE/RIBITOL
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ALA A  30
GLY A 224
ALA A 227
VAL A  10
VAL A  88
 None
 1.01A 4nkvA-2hq1A:
undetectable		 4nkvA-2hq1A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2hq1 GLUCOSE/RIBITOL
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ALA A  30
GLY A 224
ALA A 227
VAL A  10
VAL A  88
 None
 1.00A 4nkvC-2hq1A:
undetectable		 4nkvC-2hq1A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2hq1 GLUCOSE/RIBITOL
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ALA A  30
GLY A 224
ALA A 227
VAL A  10
VAL A  88
 None
 1.00A 4nkvD-2hq1A:
undetectable		 4nkvD-2hq1A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2hq1 GLUCOSE/RIBITOL
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ALA A  30
GLY A 224
ALA A 227
VAL A  10
VAL A  88
 None
 0.98A 4nkxA-2hq1A:
undetectable		 4nkxA-2hq1A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2hq1 GLUCOSE/RIBITOL
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A  26
VAL A  57
ILE A 138
ALA A 227
VAL A  88
 None
 1.13A 5n0xA-2hq1A:
2.5		 5n0xA-2hq1A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2hq1 GLUCOSE/RIBITOL
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ALA A 118
THR A 122
ILE A 137
LEU A  87
 None
 0.92A 5te8C-2hq1A:
undetectable		 5te8C-2hq1A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 2hq1 GLUCOSE/RIBITOL
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 VAL A  88
LEU A  87
LEU A   3
GLY A  12
GLY A  26
 None
 1.21A 6eu9B-2hq1A:
undetectable		 6eu9B-2hq1A:
16.31