SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hq8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM0_B_CHDB153_0 (ILEAL BILE ACID-BINDING PROTEIN)	2hq8	COELENTERAZINE-BINDI NG PROTEIN CA-BOUND APO FORM (Renilla muelleri)	4 / 7	ILE A 39 PHE A 160 PHE A 180 GLY A 132	None	1.00A	3em0B-2hq8A: undetectable	3em0B-2hq8A: 22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TWP_A_SALA404_1 (ANTHRANILATE PHOSPHORIBOSYLTRANSF ERASE)	2hq8	COELENTERAZINE-BINDI NG PROTEIN CA-BOUND APO FORM (Renilla muelleri)	4 / 7	ALA A 40 ARG A 63 ALA A 65 ARG A 33	None	1.00A	3twpA-2hq8A: undetectable	3twpA-2hq8A: 17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U40_E_ADNE251_1 (PURINE NUCLEOSIDE PHOSPHORYLASE)	2hq8	COELENTERAZINE-BINDI NG PROTEIN CA-BOUND APO FORM (Renilla muelleri)	5 / 12	ARG A 42 ARG A 22 GLY A 29 VAL A 78 ASP A 28	None None None None CA A 202 (-3.0A)	1.49A	3u40D-2hq8A: undetectable 3u40E-2hq8A: undetectable	3u40D-2hq8A: 21.37 3u40E-2hq8A: 21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XO7_B_ASDB402_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2)	2hq8	COELENTERAZINE-BINDI NG PROTEIN CA-BOUND APO FORM (Renilla muelleri)	4 / 7	TYR A 181 VAL A 131 ILE A 43 LEU A 147	None	1.22A	4xo7B-2hq8A: undetectable	4xo7B-2hq8A: 20.68

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3EM0_B_CHDB153_0","ILEAL BILE ACID-BINDING PROTEIN","2hq8","COELENTERAZINE-BINDING PROTEIN CA-BOUND APO FORM","Renilla muelleri",4,"ILE A  39;PHE A 160;PHE A 180;GLY A 132","None","1.00A","3em0B-2hq8A:undetectable","3em0B-2hq8A:22.16"],["3TWP_A_SALA404_1","ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE","2hq8","COELENTERAZINE-BINDING PROTEIN CA-BOUND APO FORM","Renilla muelleri",4,"ALA A  40;ARG A  63;ALA A  65;ARG A  33","None","1.00A","3twpA-2hq8A:undetectable","3twpA-2hq8A:17.43"],["3U40_E_ADNE251_1","PURINE NUCLEOSIDE PHOSPHORYLASE;PURINE NUCLEOSIDE PHOSPHORYLASE","2hq8","COELENTERAZINE-BINDING PROTEIN CA-BOUND APO FORM","Renilla muelleri",5,"ARG A  42;ARG A  22;GLY A  29;VAL A  78;ASP A  28","None;None;None;None; CA A 202 (-3.0A)","1.49A","3u40D-2hq8A:undetectable;3u40E-2hq8A:undetectable","3u40D-2hq8A:21.37;3u40E-2hq8A:21.37"],["4XO7_B_ASDB402_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2","2hq8","COELENTERAZINE-BINDING PROTEIN CA-BOUND APO FORM","Renilla muelleri",4,"TYR A 181;VAL A 131;ILE A  43;LEU A 147","None","1.22A","4xo7B-2hq8A:undetectable","4xo7B-2hq8A:20.68"]]