SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hqb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE
(Bacillus
halodurans) 		4 / 7 LEU A 227
TYR A 228
THR A  97
ASN A  88
 None
 1.13A 1afsA-2hqbA:
undetectable		 1afsA-2hqbA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE
(Bacillus
halodurans) 		4 / 7 LEU A 227
TYR A 228
THR A  97
ASN A  88
 None
 1.13A 1afsB-2hqbA:
undetectable		 1afsB-2hqbA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE
(Bacillus
halodurans) 		5 / 9 ALA A 115
GLU A 147
VAL A 123
GLY A 141
GLY A 111
 None
 1.04A 1bcuH-2hqbA:
undetectable		 1bcuH-2hqbA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE
(Bacillus
halodurans) 		5 / 12 ALA A 150
ALA A 142
GLY A 124
TYR A 180
LEU A 217
 None
 1.21A 1qabF-2hqbA:
undetectable		 1qabF-2hqbA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE
(Bacillus
halodurans) 		4 / 8 GLN A 222
TYR A 204
TYR A 180
TRP A 158
 None
 1.45A 2aoxA-2hqbA:
undetectable		 2aoxA-2hqbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE
(Bacillus
halodurans) 		6 / 12 ALA A 201
VAL A 190
ILE A 126
GLY A 124
VAL A 123
ILE A 194
 None
 1.34A 2avsA-2hqbA:
undetectable		 2avsA-2hqbA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE
(Bacillus
halodurans) 		4 / 7 GLY A   3
GLY A  39
PHE A  68
PHE A  72
 None
 0.85A 2qwxA-2hqbA:
5.8
2qwxB-2hqbA:
5.8		 2qwxA-2hqbA:
23.18
2qwxB-2hqbA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE
(Bacillus
halodurans) 		4 / 4 GLY A 107
TYR A 108
GLY A 141
ASP A 140
 None
 0.86A 3kl3A-2hqbA:
undetectable		 3kl3A-2hqbA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE
(Bacillus
halodurans) 		6 / 10 ALA A 201
VAL A 190
ILE A 126
GLY A 124
VAL A 123
ILE A 194
 None
 1.46A 3oxwB-2hqbA:
undetectable		 3oxwB-2hqbA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE
(Bacillus
halodurans) 		4 / 6 ALA A  46
ILE A  50
LEU A   5
ALA A  67
 None
 0.69A 3r9sA-2hqbA:
2.8		 3r9sA-2hqbA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE
(Bacillus
halodurans) 		4 / 6 ALA A  46
ILE A  50
LEU A   5
GLU A  43
 None
 0.91A 3r9sA-2hqbA:
2.8		 3r9sA-2hqbA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE
(Bacillus
halodurans) 		4 / 4 VAL A   2
PHE A  62
PHE A  68
VAL A  40
 None
 1.38A 3rv5C-2hqbA:
undetectable
3rv5D-2hqbA:
undetectable		 3rv5C-2hqbA:
17.39
3rv5D-2hqbA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE
(Bacillus
halodurans) 		4 / 4 LEU A 240
ALA A 232
PHE A  62
ASN A  59
 None
 1.49A 3vaqA-2hqbA:
3.2		 3vaqA-2hqbA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE
(Bacillus
halodurans) 		4 / 4 LEU A 240
ALA A 232
PHE A  62
ASN A  59
 None
 1.48A 3vasA-2hqbA:
4.8		 3vasA-2hqbA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE
(Bacillus
halodurans) 		4 / 6 PHE A 168
ALA A 193
ALA A 201
THR A 215
 None
 0.96A 4dtzA-2hqbA:
undetectable		 4dtzA-2hqbA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE
(Bacillus
halodurans) 		4 / 8 ALA A 201
VAL A 190
GLY A 124
ILE A 194
 None
 0.74A 4ll3A-2hqbA:
undetectable		 4ll3A-2hqbA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_B_ACTB201_0
(RETINOL-BINDING
PROTEIN 2)		 2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE
(Bacillus
halodurans) 		4 / 5 TYR A 186
TYR A 180
GLU A 134
GLN A 132
 None
 1.50A 4qztB-2hqbA:
undetectable		 4qztB-2hqbA:
22.65