SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hqj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2hqj PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Leishmania
major) 		5 / 8 ARG A 101
GLY A 106
THR A 129
ALA A 128
ALA A 127
 None
 1.31A 2ej3C-2hqjA:
undetectable		 2ej3C-2hqjA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 2hqj PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Leishmania
major) 		4 / 9 ARG A 101
ALA A  99
VAL A 138
CYH A 107
 None
 1.04A 2vufB-2hqjA:
undetectable		 2vufB-2hqjA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 2hqj PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Leishmania
major) 		4 / 8 TYR A  25
SER A  94
HIS A 102
CYH A 107
 None
 1.25A 3b9lA-2hqjA:
undetectable		 3b9lA-2hqjA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2hqj PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Leishmania
major) 		4 / 7 PHE A 139
MET A 110
ILE A 124
VAL A 142
 None
 0.98A 3p6hA-2hqjA:
undetectable		 3p6hA-2hqjA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2hqj PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Leishmania
major) 		4 / 5 TYR A  55
VAL A 168
SER A  58
GLY A  71
 None
 1.35A 3v4tA-2hqjA:
undetectable
3v4tD-2hqjA:
undetectable		 3v4tA-2hqjA:
20.10
3v4tD-2hqjA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2hqj PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Leishmania
major) 		4 / 6 TYR A  55
HIS A  54
VAL A 167
PHE A 122
 None
PO4  A 180 (-3.6A)
None
None
 1.20A 4a97E-2hqjA:
undetectable		 4a97E-2hqjA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 2hqj PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Leishmania
major) 		5 / 9 MET A 110
PHE A 139
ALA A  26
LEU A  24
GLY A 140
 None
 1.48A 4l6va-2hqjA:
undetectable
4l6vf-2hqjA:
undetectable		 4l6va-2hqjA:
13.85
4l6vf-2hqjA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 2hqj PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Leishmania
major) 		4 / 5 SER A 120
GLY A 119
GLU A  83
PHE A  74
 None
 1.28A 4r82A-2hqjA:
undetectable
4r82B-2hqjA:
undetectable		 4r82A-2hqjA:
20.83
4r82B-2hqjA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 2hqj PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Leishmania
major) 		4 / 7 ILE A  69
PHE A  60
VAL A 149
ILE A  20
 None
 1.01A 4zzbC-2hqjA:
undetectable
4zzbD-2hqjA:
undetectable		 4zzbC-2hqjA:
20.06
4zzbD-2hqjA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 2hqj PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Leishmania
major) 		5 / 12 GLY A 119
ILE A  85
ASN A 112
PHE A  36
LEU A 108
 None
 1.07A 5fa8A-2hqjA:
undetectable		 5fa8A-2hqjA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2hqj PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Leishmania
major) 		5 / 9 LEU A 108
ARG A  37
GLU A  93
PHE A 139
VAL A 137
 None
 1.44A 5igzA-2hqjA:
undetectable		 5igzA-2hqjA:
20.19