SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hqm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 213
VAL A 215
TRP A  73
 None
 0.97A 1av2A-2hqmA:
undetectable
1av2B-2hqmA:
undetectable		 1av2A-2hqmA:
3.19
1av2B-2hqmA:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 215
GLY A 214
TYR A 248
GLU A 288
 None
 1.01A 1fduD-2hqmA:
5.8		 1fduD-2hqmA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 9 GLY A  65
GLY A 170
GLY A 169
ASP A 334
ARG A 295
 FAD  A1001 (-3.5A)
None
FAD  A1001 (-3.2A)
FAD  A1001 (-2.9A)
FAD  A1001 (-3.8A)
 0.94A 1mxdA-2hqmA:
undetectable		 1mxdA-2hqmA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 11 GLY A  65
GLY A 170
GLY A 169
ASP A 334
ARG A 295
 FAD  A1001 (-3.5A)
None
FAD  A1001 (-3.2A)
FAD  A1001 (-2.9A)
FAD  A1001 (-3.8A)
 0.94A 1mxgA-2hqmA:
undetectable		 1mxgA-2hqmA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 141
SER A 331
ILE A 316
ASN A 325
 None
 1.00A 1pnlA-2hqmA:
undetectable
1pnlB-2hqmA:
undetectable		 1pnlA-2hqmA:
16.14
1pnlB-2hqmA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 232
THR A 231
GLU A 238
LEU A 233
 None
None
GSH  A3001 (-3.8A)
None
 1.04A 1s8fB-2hqmA:
undetectable		 1s8fB-2hqmA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 165
GLY A  32
GLY A  30
SER A 331
ALA A 345
 None
FAD  A1001 (-3.2A)
FAD  A1001 (-3.3A)
None
FAD  A1001 ( 4.1A)
 1.02A 1v2xA-2hqmA:
2.5		 1v2xA-2hqmA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 438
PRO A 380
ILE A 448
LEU A 449
 None
 1.07A 1ya4B-2hqmA:
undetectable		 1ya4B-2hqmA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 438
PRO A 380
ILE A 448
LEU A 449
 None
 1.15A 1ya4C-2hqmA:
undetectable		 1ya4C-2hqmA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  51
TYR A  26
THR A  49
VAL A 132
 None
 1.10A 2uz2A-2hqmA:
undetectable		 2uz2A-2hqmA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 330
LEU A 165
LEU A 352
ALA A  42
 None
 1.04A 2wekA-2hqmA:
3.0		 2wekA-2hqmA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 164
TYR A  24
VAL A  28
TYR A 159
 None
 1.34A 2xz5D-2hqmA:
undetectable
2xz5E-2hqmA:
undetectable		 2xz5D-2hqmA:
16.88
2xz5E-2hqmA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 11 GLY A  31
GLY A  58
THR A  60
ARG A  40
ALA A  37
 FAD  A1001 ( 4.8A)
None
FAD  A1001 (-3.5A)
PO4  A5001 (-3.6A)
PO4  A5001 (-3.3A)
 1.05A 3g88A-2hqmA:
3.5		 3g88A-2hqmA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  31
GLY A  58
THR A  60
ARG A  40
ALA A  37
 FAD  A1001 ( 4.8A)
None
FAD  A1001 (-3.5A)
PO4  A5001 (-3.6A)
PO4  A5001 (-3.3A)
 1.04A 3g89A-2hqmA:
undetectable		 3g89A-2hqmA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 11 GLY A  31
GLY A  58
THR A  60
ARG A  40
ALA A  37
 FAD  A1001 ( 4.8A)
None
FAD  A1001 (-3.5A)
PO4  A5001 (-3.6A)
PO4  A5001 (-3.3A)
 1.05A 3g89B-2hqmA:
3.4		 3g89B-2hqmA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  31
GLY A  58
THR A  60
ARG A  40
ALA A  37
 FAD  A1001 ( 4.8A)
None
FAD  A1001 (-3.5A)
PO4  A5001 (-3.6A)
PO4  A5001 (-3.3A)
 1.07A 3g8bA-2hqmA:
undetectable		 3g8bA-2hqmA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  31
GLY A  58
THR A  60
ARG A  40
ALA A  37
 FAD  A1001 ( 4.8A)
None
FAD  A1001 (-3.5A)
PO4  A5001 (-3.6A)
PO4  A5001 (-3.3A)
 1.08A 3g8bB-2hqmA:
undetectable		 3g8bB-2hqmA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 5 THR A 292
ILE A 208
GLU A 211
PHE A 191
 None
FAD  A1001 ( 4.1A)
None
None
 1.39A 4ac9C-2hqmA:
undetectable		 4ac9C-2hqmA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 5 THR A 292
ILE A 208
GLU A 211
PHE A 191
 None
FAD  A1001 ( 4.1A)
None
None
 1.36A 4acaC-2hqmA:
undetectable		 4acaC-2hqmA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 5 THR A 292
ILE A 208
GLU A 211
PHE A 191
 None
FAD  A1001 ( 4.1A)
None
None
 1.36A 4acbC-2hqmA:
undetectable		 4acbC-2hqmA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 136
VAL A 134
GLU A 128
 None
 0.79A 4fvqA-2hqmA:
undetectable		 4fvqA-2hqmA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 252
GLU A 222
THR A 223
 None
 0.32A 4kouA-2hqmA:
undetectable		 4kouA-2hqmA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 8 ALA A 167
VAL A  28
GLY A  34
ALA A 345
GLY A 349
 FAD  A1001 (-4.5A)
None
FAD  A1001 (-3.5A)
FAD  A1001 ( 4.1A)
None
 1.24A 4zjzB-2hqmA:
undetectable		 4zjzB-2hqmA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 352
ALA A  42
LEU A 356
VAL A 132
 None
 1.11A 5cr1A-2hqmA:
undetectable		 5cr1A-2hqmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 219
GLY A 214
ARG A  81
THR A  80
ALA A  79
 None
 1.08A 5o96A-2hqmA:
2.3
5o96B-2hqmA:
2.6		 5o96A-2hqmA:
20.17
5o96B-2hqmA:
20.17