SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hqo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 2hqo PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Helicobacter
pylori) 		4 / 7 LEU A   5
LEU A   4
ILE A  62
ARG A  61
 None
 1.15A 2hc4A-2hqoA:
undetectable		 2hc4A-2hqoA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2hqo PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Helicobacter
pylori) 		4 / 8 ASP A  93
LEU A 105
LEU A  72
SER A  75
 None
 0.86A 3lm8B-2hqoA:
2.4
3lm8D-2hqoA:
2.1		 3lm8B-2hqoA:
17.84
3lm8D-2hqoA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2hqo PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Helicobacter
pylori) 		5 / 12 GLU A  82
ALA A  86
GLY A  90
SER A  60
ASP A  92
 None
 1.42A 3ou6D-2hqoA:
undetectable		 3ou6D-2hqoA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 2hqo PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Helicobacter
pylori) 		5 / 12 GLY A  90
GLN A  89
ALA A  91
VAL A  73
GLU A  82
 None
 1.13A 4pd5A-2hqoA:
undetectable		 4pd5A-2hqoA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 2hqo PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Helicobacter
pylori) 		5 / 12 GLY A  90
GLN A  89
ALA A  91
VAL A  73
GLU A  82
 None
 1.09A 4pd9A-2hqoA:
undetectable		 4pd9A-2hqoA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2hqo PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Helicobacter
pylori) 		4 / 5 TYR A  94
VAL A  73
ASP A  92
ALA A  91
 None
 1.07A 5otrA-2hqoA:
undetectable		 5otrA-2hqoA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2hqo PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Helicobacter
pylori) 		5 / 9 LEU A  20
ILE A 109
LEU A 113
PHE A  58
ILE A  62
 None
 0.98A 5vkqC-2hqoA:
undetectable
5vkqD-2hqoA:
undetectable		 5vkqC-2hqoA:
5.76
5vkqD-2hqoA:
5.76