SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hqy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 2hqy CONSERVED
HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 10 GLU A 236
ALA A 219
LEU A 171
LEU A 194
GLU A 190
 None
None
None
None
COA  A1001 (-3.2A)
 1.37A 1a29A-2hqyA:
undetectable		 1a29A-2hqyA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2hqy CONSERVED
HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 LEU A  52
ILE A 226
PHE A  18
VAL A  68
 None
 0.77A 1d4sB-2hqyA:
undetectable		 1d4sB-2hqyA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 2hqy CONSERVED
HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 11 THR A 187
GLU A 190
GLU A 268
LEU A 275
ILE A 272
 COA  A1001 (-4.8A)
COA  A1001 (-3.2A)
None
COA  A1001 ( 4.7A)
COA  A1001 (-4.7A)
 1.40A 1t6zA-2hqyA:
undetectable		 1t6zA-2hqyA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 2hqy CONSERVED
HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 SER A 241
VAL A 213
TYR A 152
ASP A 239
 None
 1.32A 2x45A-2hqyA:
undetectable		 2x45A-2hqyA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2hqy CONSERVED
HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A  54
SER A  36
LEU A 204
ILE A  15
MET A 224
 None
 1.32A 2xkwB-2hqyA:
undetectable		 2xkwB-2hqyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2hqy CONSERVED
HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 SER A  36
GLU A 268
ASP A 117
 None
 0.81A 2zulA-2hqyA:
undetectable		 2zulA-2hqyA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2hqy CONSERVED
HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 5 GLN A  44
PHE A  54
LEU A  80
PHE A  91
 None
 1.39A 3ablC-2hqyA:
undetectable
3ablJ-2hqyA:
undetectable		 3ablC-2hqyA:
20.62
3ablJ-2hqyA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 2hqy CONSERVED
HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 SER A 241
VAL A 213
TYR A 152
ASP A 239
 None
 1.23A 3bu1A-2hqyA:
undetectable		 3bu1A-2hqyA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2hqy CONSERVED
HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 GLU A 172
LEU A 194
LEU A  40
 None
 0.65A 3ohtA-2hqyA:
undetectable		 3ohtA-2hqyA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2hqy CONSERVED
HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 GLU A 172
LEU A 194
LEU A  40
 None
 0.63A 3ohtB-2hqyA:
undetectable		 3ohtB-2hqyA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 2hqy CONSERVED
HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 GLU A 116
TYR A 291
SER A  98
 None
 0.90A 4at0A-2hqyA:
undetectable		 4at0A-2hqyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 2hqy CONSERVED
HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 4 CYH A  35
LEU A   9
LEU A 204
ALA A 203
 None
 1.12A 5hpuA-2hqyA:
undetectable
5hpuB-2hqyA:
undetectable		 5hpuA-2hqyA:
16.09
5hpuB-2hqyA:
12.03