SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hr2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 2hr2 HYPOTHETICAL PROTEIN
(Chlorobaculum
tepidum) 		5 / 11 ILE A 101
GLY A  97
GLU A  96
LEU A  83
GLY A  90
 None
 1.46A 1i7qA-2hr2A:
undetectable		 1i7qA-2hr2A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 2hr2 HYPOTHETICAL PROTEIN
(Chlorobaculum
tepidum) 		4 / 7 SER A 106
ALA A  82
LEU A  99
SER A 102
 GOL  A 159 ( 4.4A)
None
None
GOL  A 159 (-2.8A)
 0.94A 3cfqA-2hr2A:
undetectable
3cfqB-2hr2A:
undetectable		 3cfqA-2hr2A:
23.84
3cfqB-2hr2A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 2hr2 HYPOTHETICAL PROTEIN
(Chlorobaculum
tepidum) 		3 / 3 GLU A  64
GLY A  61
SER A 106
 GOL  A 159 (-3.5A)
None
GOL  A 159 ( 4.4A)
 0.69A 4b53B-2hr2A:
undetectable		 4b53B-2hr2A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 2hr2 HYPOTHETICAL PROTEIN
(Chlorobaculum
tepidum) 		4 / 7 ALA A  82
LEU A  99
SER A 102
SER A 106
 None
None
GOL  A 159 (-2.8A)
GOL  A 159 ( 4.4A)
 0.93A 4ikjA-2hr2A:
undetectable
4ikjB-2hr2A:
undetectable		 4ikjA-2hr2A:
24.05
4ikjB-2hr2A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2hr2 HYPOTHETICAL PROTEIN
(Chlorobaculum
tepidum) 		4 / 8 SER A 106
ALA A  82
LEU A  99
SER A 102
 GOL  A 159 ( 4.4A)
None
None
GOL  A 159 (-2.8A)
 0.97A 4ikjA-2hr2A:
undetectable
4ikjB-2hr2A:
undetectable		 4ikjA-2hr2A:
24.05
4ikjB-2hr2A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2hr2 HYPOTHETICAL PROTEIN
(Chlorobaculum
tepidum) 		4 / 8 ALA A  82
LEU A  99
SER A 102
SER A 106
 None
None
GOL  A 159 (-2.8A)
GOL  A 159 ( 4.4A)
 0.97A 4ikkA-2hr2A:
undetectable
4ikkB-2hr2A:
undetectable		 4ikkA-2hr2A:
24.05
4ikkB-2hr2A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 2hr2 HYPOTHETICAL PROTEIN
(Chlorobaculum
tepidum) 		4 / 7 SER A 106
ALA A  82
LEU A  99
SER A 102
 GOL  A 159 ( 4.4A)
None
None
GOL  A 159 (-2.8A)
 0.99A 4ikkA-2hr2A:
undetectable
4ikkB-2hr2A:
undetectable		 4ikkA-2hr2A:
24.05
4ikkB-2hr2A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 2hr2 HYPOTHETICAL PROTEIN
(Chlorobaculum
tepidum) 		4 / 8 LEU A  99
GLY A  97
GLU A  96
MET A 130
 None
 0.85A 4rjdA-2hr2A:
undetectable
4rjdB-2hr2A:
undetectable		 4rjdA-2hr2A:
18.30
4rjdB-2hr2A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2hr2 HYPOTHETICAL PROTEIN
(Chlorobaculum
tepidum) 		5 / 9 ALA A  60
SER A 102
ALA A  63
SER A 106
ALA A  65
 None
GOL  A 159 (-2.8A)
None
GOL  A 159 ( 4.4A)
None
 1.18A 4twdA-2hr2A:
4.0
4twdB-2hr2A:
4.2
4twdC-2hr2A:
4.1
4twdD-2hr2A:
4.2
4twdE-2hr2A:
4.0		 4twdA-2hr2A:
19.72
4twdB-2hr2A:
19.72
4twdC-2hr2A:
19.72
4twdD-2hr2A:
19.72
4twdE-2hr2A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2hr2 HYPOTHETICAL PROTEIN
(Chlorobaculum
tepidum) 		6 / 12 VAL A 127
ALA A 120
ALA A 108
VAL A 104
LEU A 111
GLY A 113
 None
 1.44A 5igtA-2hr2A:
undetectable		 5igtA-2hr2A:
21.45