SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hr7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 2hr7 INSULIN RECEPTOR
(Homo
sapiens) 		5 / 12 ILE A 439
ALA A 458
PHE A 427
PHE A 428
ILE A 370
 None
GOL  A 597 (-3.6A)
None
None
None
 1.13A 1dhfA-2hr7A:
undetectable		 1dhfA-2hr7A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 2hr7 INSULIN RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 327
PHE A 381
SER A 373
ILE A 370
LEU A 368
 None
 1.14A 1dlsA-2hr7A:
undetectable		 1dlsA-2hr7A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2hr7 INSULIN RECEPTOR
(Homo
sapiens) 		4 / 8 ALA A  92
ILE A 119
ILE A 136
ILE A 112
 None
 0.66A 1hshD-2hr7A:
undetectable		 1hshD-2hr7A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 2hr7 INSULIN RECEPTOR
(Homo
sapiens) 		4 / 8 ILE A  13
LEU A  17
PHE A  46
GLY A  68
 None
None
GOL  A 610 (-4.9A)
None
 1.05A 1os6A-2hr7A:
undetectable		 1os6A-2hr7A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 2hr7 INSULIN RECEPTOR
(Homo
sapiens) 		3 / 3 LEU A  17
LEU A  33
PHE A  46
 None
None
GOL  A 610 (-4.9A)
 0.58A 2pgrA-2hr7A:
undetectable		 2pgrA-2hr7A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 2hr7 INSULIN RECEPTOR
(Homo
sapiens) 		3 / 3 LEU A 368
LEU A 408
PHE A 382
 None
 0.72A 2pgrA-2hr7A:
undetectable		 2pgrA-2hr7A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 2hr7 INSULIN RECEPTOR
(Homo
sapiens) 		5 / 11 LEU A  36
ILE A  13
ARG A  19
VAL A  94
LEU A  93
 None
 1.36A 3a9eB-2hr7A:
undetectable		 3a9eB-2hr7A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 2hr7 INSULIN RECEPTOR
(Homo
sapiens) 		4 / 7 ILE A 361
LEU A 314
THR A 392
ARG A 371
 None
None
None
SO4  A 602 ( 3.0A)
 1.19A 3nxuA-2hr7A:
undetectable		 3nxuA-2hr7A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2hr7 INSULIN RECEPTOR
(Homo
sapiens) 		5 / 10 ILE A 336
GLY A 338
GLY A 317
SER A 326
THR A 320
 None
None
None
None
SO4  A 607 (-4.4A)
 0.97A 4fakA-2hr7A:
undetectable		 4fakA-2hr7A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 2hr7 INSULIN RECEPTOR
(Homo
sapiens) 		4 / 7 ILE A  13
LEU A  17
PHE A  46
GLY A  68
 None
None
GOL  A 610 (-4.9A)
None
 0.96A 4hbfA-2hr7A:
undetectable		 4hbfA-2hr7A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 2hr7 INSULIN RECEPTOR
(Homo
sapiens) 		4 / 7 ILE A  13
LEU A  17
PHE A  46
GLY A  68
 None
None
GOL  A 610 (-4.9A)
None
 1.00A 4hc3A-2hr7A:
undetectable		 4hc3A-2hr7A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2hr7 INSULIN RECEPTOR
(Homo
sapiens) 		4 / 8 VAL A 117
TRP A 133
ILE A 136
LEU A 106
 None
 0.92A 4jq1B-2hr7A:
undetectable		 4jq1B-2hr7A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 2hr7 INSULIN RECEPTOR
(Homo
sapiens) 		5 / 12 GLY A 463
ARG A 409
ALA A 458
ALA A 402
ASP A 404
 None
None
GOL  A 597 (-3.6A)
None
None
 1.13A 4kicA-2hr7A:
undetectable		 4kicA-2hr7A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hr7 INSULIN RECEPTOR
(Homo
sapiens) 		4 / 8 LEU A  54
LEU A  79
LEU A 106
ILE A  29
 None
 0.88A 4klaA-2hr7A:
undetectable		 4klaA-2hr7A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2hr7 INSULIN RECEPTOR
(Homo
sapiens) 		5 / 10 LEU A 354
LEU A 330
LEU A 340
ILE A 342
PHE A 381
 None
 1.06A 4odoA-2hr7A:
undetectable		 4odoA-2hr7A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 2hr7 INSULIN RECEPTOR
(Homo
sapiens) 		4 / 8 LEU A  69
GLY A  68
GLU A  70
GLU A  44
 GOL  A 610 (-4.5A)
None
GOL  A 585 ( 3.8A)
None
 0.79A 4rjdA-2hr7A:
undetectable
4rjdB-2hr7A:
undetectable		 4rjdA-2hr7A:
9.35
4rjdB-2hr7A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 2hr7 INSULIN RECEPTOR
(Homo
sapiens) 		3 / 3 THR A 461
ALA A 458
ASN A 462
 GOL  A 597 (-3.0A)
GOL  A 597 (-3.6A)
None
 0.52A 5ersA-2hr7A:
undetectable		 5ersA-2hr7A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 2hr7 INSULIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A 117
ILE A 119
LEU A  72
LEU A  61
LEU A  63
 None
 1.28A 5tiwA-2hr7A:
undetectable		 5tiwA-2hr7A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2hr7 INSULIN RECEPTOR
(Homo
sapiens) 		4 / 8 ASP A 132
ILE A 136
ARG A 181
ASN A 108
 None
None
GOL  A 595 (-3.3A)
NAG  A 541 (-3.6A)
 1.21A 6hisA-2hr7A:
undetectable
6hisB-2hr7A:
undetectable		 6hisA-2hr7A:
10.69
6hisB-2hr7A:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2hr7 INSULIN RECEPTOR
(Homo
sapiens) 		4 / 8 ASP A 132
ILE A 136
ARG A 181
ASN A 108
 None
None
GOL  A 595 (-3.3A)
NAG  A 541 (-3.6A)
 1.22A 6hisB-2hr7A:
undetectable
6hisC-2hr7A:
undetectable		 6hisB-2hr7A:
10.69
6hisC-2hr7A:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2hr7 INSULIN RECEPTOR
(Homo
sapiens) 		4 / 8 ASP A 132
ILE A 136
ARG A 181
ASN A 108
 None
None
GOL  A 595 (-3.3A)
NAG  A 541 (-3.6A)
 1.22A 6hisC-2hr7A:
undetectable
6hisD-2hr7A:
undetectable		 6hisC-2hr7A:
10.69
6hisD-2hr7A:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2hr7 INSULIN RECEPTOR
(Homo
sapiens) 		4 / 8 ASP A 132
ILE A 136
ARG A 181
ASN A 108
 None
None
GOL  A 595 (-3.3A)
NAG  A 541 (-3.6A)
 1.21A 6hisD-2hr7A:
undetectable
6hisE-2hr7A:
undetectable		 6hisD-2hr7A:
10.69
6hisE-2hr7A:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2hr7 INSULIN RECEPTOR
(Homo
sapiens) 		4 / 8 ASN A 108
ASP A 132
ILE A 136
ARG A 181
 NAG  A 541 (-3.6A)
None
None
GOL  A 595 (-3.3A)
 1.23A 6hisA-2hr7A:
undetectable
6hisE-2hr7A:
undetectable		 6hisA-2hr7A:
10.69
6hisE-2hr7A:
10.69