SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hrb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)
2hrb CARBONYL REDUCTASE
[NADPH] 3

(Homo
sapiens)
4 / 8 ALA A  46
LEU A  35
LEU A  19
ALA A  22
None
0.79A 1e7cA-2hrbA:
undetectable
1e7cA-2hrbA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)
2hrb CARBONYL REDUCTASE
[NADPH] 3

(Homo
sapiens)
5 / 12 LEU A 256
VAL A 252
VAL A  33
LEU A  50
LEU A  55
None
1.16A 1s19A-2hrbA:
undetectable
1s19A-2hrbA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
2hrb CARBONYL REDUCTASE
[NADPH] 3

(Homo
sapiens)
5 / 12 GLY A  12
ARG A  38
ARG A  15
ASP A  63
ALA A  91
NAP  A1001 (-3.4A)
NAP  A1001 ( 3.5A)
NAP  A1001 (-3.8A)
NAP  A1001 (-3.6A)
NAP  A1001 (-3.5A)
1.07A 2br4F-2hrbA:
5.9
2br4F-2hrbA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)
2hrb CARBONYL REDUCTASE
[NADPH] 3

(Homo
sapiens)
4 / 8 ILE A 138
ASN A 114
SER A 197
SER A 140
NAP  A1001 (-4.2A)
None
None
NAP  A1001 ( 4.0A)
1.14A 2zw9B-2hrbA:
5.8
2zw9B-2hrbA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)
2hrb CARBONYL REDUCTASE
[NADPH] 3

(Homo
sapiens)
4 / 6 MET A 121
PRO A 127
GLY A  83
MET A 129
None
None
GOL  A2003 ( 3.7A)
None
1.36A 3aqiA-2hrbA:
3.0
3aqiA-2hrbA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
2hrb CARBONYL REDUCTASE
[NADPH] 3

(Homo
sapiens)
4 / 8 LEU A 208
SER A 205
ARG A 206
VAL A 201
None
None
GOL  A2002 (-3.6A)
None
1.00A 3ax9A-2hrbA:
undetectable
3ax9A-2hrbA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)
2hrb CARBONYL REDUCTASE
[NADPH] 3

(Homo
sapiens)
5 / 12 THR A  11
ASN A  14
ILE A  70
ASN A  90
THR A 118
None
NAP  A1001 (-3.1A)
None
NAP  A1001 (-3.3A)
None
1.17A 3eeyF-2hrbA:
9.1
3eeyF-2hrbA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)
2hrb CARBONYL REDUCTASE
[NADPH] 3

(Homo
sapiens)
5 / 12 THR A  11
ASN A  14
ILE A  70
ASN A  90
THR A 118
None
NAP  A1001 (-3.1A)
None
NAP  A1001 (-3.3A)
None
1.18A 3eeyI-2hrbA:
9.4
3eeyI-2hrbA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))
2hrb CARBONYL REDUCTASE
[NADPH] 3

(Homo
sapiens)
5 / 12 THR A  36
THR A  11
LEU A 125
ILE A  70
LEU A  25
None
1.39A 3gwxB-2hrbA:
undetectable
3gwxB-2hrbA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)
2hrb CARBONYL REDUCTASE
[NADPH] 3

(Homo
sapiens)
4 / 5 SER A 140
ILE A  17
TYR A 194
GLY A 229
NAP  A1001 ( 4.0A)
NAP  A1001 (-3.8A)
NAP  A1001 ( 4.7A)
None
0.93A 3uboB-2hrbA:
5.8
3uboB-2hrbA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
2hrb CARBONYL REDUCTASE
[NADPH] 3

(Homo
sapiens)
5 / 11 LEU A  50
GLY A  43
SER A  56
VAL A  34
ALA A  22
None
1.03A 5o96G-2hrbA:
2.3
5o96G-2hrbA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)
2hrb CARBONYL REDUCTASE
[NADPH] 3

(Homo
sapiens)
4 / 6 ASN A 137
ALA A 225
PRO A 251
VAL A 136
None
1.18A 5umd2-2hrbA:
undetectable
5umdF-2hrbA:
undetectable
5umd2-2hrbA:
14.13
5umdF-2hrbA:
13.74