SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hrj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2hrj TALIN-1
(Gallus
gallus) 		3 / 3 GLY A  60
GLU A 103
ASN A  63
 None
 0.73A 1zq9A-2hrjA:
undetectable		 1zq9A-2hrjA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2hrj TALIN-1
(Gallus
gallus) 		5 / 11 ASN A  25
LEU A  24
VAL A 111
ALA A 114
PHE A  77
 None
 1.26A 3n23C-2hrjA:
undetectable		 3n23C-2hrjA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 2hrj TALIN-1
(Gallus
gallus) 		4 / 8 GLY A  99
GLN A  56
ASN A 100
HIS A  95
 None
 1.02A 4wryA-2hrjA:
undetectable		 4wryA-2hrjA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 2hrj TALIN-1
(Gallus
gallus) 		4 / 8 GLY A  99
GLN A  56
ASN A 100
HIS A  95
 None
 0.98A 4wrzA-2hrjA:
undetectable		 4wrzA-2hrjA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 2hrj TALIN-1
(Gallus
gallus) 		3 / 3 ASN A  97
TYR A  53
CYH A  48
 None
 0.99A 5lsuB-2hrjA:
undetectable		 5lsuB-2hrjA:
19.84