SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hro'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		3 / 3 ALA A  76
HIS A  77
VAL A  80
 None
 0.47A 1lqtB-2hroA:
undetectable		 1lqtB-2hroA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		3 / 3 ALA A  76
HIS A  77
VAL A  80
 None
 0.49A 1lquB-2hroA:
undetectable		 1lquB-2hroA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		4 / 5 ILE A 429
ILE A 482
ILE A 433
LEU A 521
 None
 0.90A 1zgyA-2hroA:
undetectable		 1zgyA-2hroA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		5 / 11 GLU A 313
ALA A 317
PRO A 309
ALA A 377
PRO A 279
 None
 1.35A 2admA-2hroA:
undetectable		 2admA-2hroA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		3 / 3 ASP A 465
ASP A 456
ASN A 353
 None
SO4  A 900 ( 4.6A)
None
 0.78A 2bm9D-2hroA:
undetectable		 2bm9D-2hroA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		5 / 11 LEU A  78
LEU A  81
ILE A  58
PRO A 150
ASN A 149
 None
 1.10A 2ft9A-2hroA:
undetectable		 2ft9A-2hroA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		4 / 4 LEU A 515
PRO A 514
LEU A 549
ARG A 552
 None
 1.38A 2pnjB-2hroA:
undetectable		 2pnjB-2hroA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		5 / 11 LEU A 407
LEU A 375
ILE A 389
ALA A 377
LEU A 387
 None
 1.21A 2q72A-2hroA:
undetectable		 2q72A-2hroA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		3 / 3 LEU A 515
PRO A 514
ARG A 552
 None
 0.62A 2qd5A-2hroA:
undetectable		 2qd5A-2hroA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		3 / 3 MET A 308
GLU A 311
ASN A 413
 None
 1.06A 3a27A-2hroA:
undetectable		 3a27A-2hroA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		5 / 12 ILE A 513
LEU A 516
VAL A 486
ILE A 482
MET A 502
 None
 0.95A 3adxB-2hroA:
undetectable		 3adxB-2hroA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		4 / 5 GLU A 523
LEU A 521
HIS A 494
GLY A 520
 None
 1.17A 3pp1A-2hroA:
undetectable		 3pp1A-2hroA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		5 / 12 LEU A 483
SER A 550
PHE A 524
ILE A 538
LEU A 272
 None
 1.19A 3w67D-2hroA:
2.2		 3w67D-2hroA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		5 / 12 LEU A 517
ILE A 513
LEU A 272
GLU A 291
ARG A 535
 None
 1.44A 4b9zA-2hroA:
7.5		 4b9zA-2hroA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		4 / 7 ASP A 522
GLY A 501
VAL A 270
HIS A 494
 None
 0.93A 4c5nA-2hroA:
3.3		 4c5nA-2hroA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		4 / 5 GLN A 510
THR A 511
THR A 454
LEU A 521
 None
 1.13A 4lvcC-2hroA:
undetectable		 4lvcC-2hroA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		5 / 12 LEU A 519
THR A 454
ILE A 482
ILE A 490
ILE A 452
 None
 1.22A 4rp8C-2hroA:
undetectable		 4rp8C-2hroA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		4 / 4 GLN A 510
THR A 511
THR A 454
LEU A 521
 None
 1.13A 5m5kA-2hroA:
undetectable		 5m5kA-2hroA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		4 / 4 GLN A 510
THR A 511
THR A 454
LEU A 521
 None
 1.11A 5m5kC-2hroA:
undetectable		 5m5kC-2hroA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		4 / 4 GLN A 510
THR A 511
THR A 454
LEU A 521
 None
 1.15A 5m66B-2hroA:
undetectable		 5m66B-2hroA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		4 / 5 ALA A 317
VAL A 321
PHE A 300
ILE A 293
 None
 1.01A 5of1A-2hroA:
undetectable		 5of1A-2hroA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		4 / 5 ALA A 317
VAL A 321
PHE A 300
ILE A 293
 None
 0.98A 5of1B-2hroA:
undetectable		 5of1B-2hroA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		3 / 3 ARG A 535
LYS A 328
ARG A 539
 None
 1.47A 6az3C-2hroA:
undetectable
6az3L-2hroA:
undetectable
6az3M-2hroA:
undetectable		 6az3C-2hroA:
9.83
6az3L-2hroA:
8.86
6az3M-2hroA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		4 / 6 ALA A 440
SER A 435
THR A 461
ILE A 482
 None
 0.79A 6f8cA-2hroA:
undetectable		 6f8cA-2hroA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		4 / 5 GLN A 510
THR A 511
THR A 454
LEU A 521
 None
 1.12A 6gbnA-2hroA:
undetectable		 6gbnA-2hroA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		4 / 5 GLN A 510
THR A 511
THR A 454
LEU A 521
 None
 1.12A 6gbnD-2hroA:
undetectable		 6gbnD-2hroA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		4 / 8 GLY A  46
PHE A  44
GLY A 144
ALA A 102
 None
 0.79A 6hu9H-2hroA:
undetectable
6hu9e-2hroA:
undetectable		 6hu9H-2hroA:
8.91
6hu9e-2hroA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Staphylococcus
carnosus) 		5 / 12 GLY A 504
CYH A 503
SER A 525
ILE A 452
MET A 390
 None
 0.94A 6md4A-2hroA:
undetectable		 6md4A-2hroA:
9.40