SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hru'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		4 / 8 GLU A  70
LEU A 481
GLU A 248
THR A  38
 MG  A 901 ( 2.8A)
None
MG  A 903 (-3.2A)
None
 0.71A 1ie4B-2hruA:
undetectable
1ie4D-2hruA:
undetectable		 1ie4B-2hruA:
14.71
1ie4D-2hruA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		4 / 8 LEU A 552
VAL A 515
GLY A 599
LEU A 546
 None
 0.82A 1jlbA-2hruA:
undetectable		 1jlbA-2hruA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		4 / 8 LEU A 266
GLY A 241
ILE A 278
MET A 271
 None
 0.77A 1n13A-2hruA:
0.0
1n13F-2hruA:
1.1		 1n13A-2hruA:
7.68
1n13F-2hruA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 12 ALA A 104
LEU A 402
SER A  64
THR A 441
THR A 103
 None
 1.12A 1qzfA-2hruA:
undetectable		 1qzfA-2hruA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 12 ALA A 104
LEU A 402
SER A  64
THR A 441
THR A 103
 None
 1.12A 1qzfB-2hruA:
undetectable		 1qzfB-2hruA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 12 ALA A 104
LEU A 402
SER A  64
THR A 441
THR A 103
 None
 1.11A 1qzfC-2hruA:
undetectable		 1qzfC-2hruA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 12 ALA A 104
LEU A 402
SER A  64
THR A 441
THR A 103
 None
 1.12A 1qzfD-2hruA:
undetectable		 1qzfD-2hruA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 12 ALA A 104
LEU A 402
SER A  64
THR A 441
THR A 103
 None
 1.12A 1qzfE-2hruA:
undetectable		 1qzfE-2hruA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 12 ALA A  24
GLY A 240
GLY A 241
LEU A 277
LEU A 266
 None
 1.02A 1ya4A-2hruA:
undetectable		 1ya4A-2hruA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 8 GLY A  55
SER A 476
ALA A 475
LEU A 402
ILE A  69
 None
 0.93A 1yajC-2hruA:
undetectable		 1yajC-2hruA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 12 ASN A 151
LEU A 153
ALA A 104
ILE A 118
LEU A 138
 None
 1.02A 2aclA-2hruA:
undetectable
2aclE-2hruA:
undetectable		 2aclA-2hruA:
18.75
2aclE-2hruA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		4 / 7 ASN A 160
ASP A  61
THR A  48
GLY A  49
 None
 1.03A 2f6dA-2hruA:
undetectable		 2f6dA-2hruA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 12 ILE A  69
GLU A 137
LEU A 149
ALA A 422
MET A 459
 None
 1.46A 2jj8C-2hruA:
undetectable		 2jj8C-2hruA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		4 / 8 ILE A 278
MET A 271
LEU A 266
GLY A 241
 None
 0.80A 2qqcH-2hruA:
1.2
2qqcK-2hruA:
undetectable		 2qqcH-2hruA:
12.32
2qqcK-2hruA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		4 / 8 ILE A 278
MET A 271
LEU A 266
GLY A 241
 None
 0.81A 2qqdB-2hruA:
undetectable
2qqdC-2hruA:
1.6		 2qqdB-2hruA:
12.32
2qqdC-2hruA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 10 GLY A  90
GLY A  89
THR A  86
TYR A 125
GLU A  70
 None
None
None
None
MG  A 901 ( 2.8A)
 1.24A 3fw1A-2hruA:
undetectable		 3fw1A-2hruA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		4 / 4 LEU A 601
PRO A 512
LEU A 565
ARG A 561
 None
 1.34A 3hcoB-2hruA:
2.7		 3hcoB-2hruA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		4 / 4 GLY A 117
TYR A  81
GLY A 121
ASP A 124
 None
 1.06A 3kl3A-2hruA:
undetectable		 3kl3A-2hruA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		4 / 7 ALA A 389
SER A 401
VAL A 502
VAL A 391
 None
 0.70A 3o14A-2hruA:
undetectable		 3o14A-2hruA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		4 / 6 GLY A 135
GLY A 136
LEU A 138
HIS A 375
 None
 0.83A 3o9mB-2hruA:
undetectable		 3o9mB-2hruA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 12 LEU A 337
ALA A 251
ASN A 254
ILE A 175
VAL A 334
 None
 1.05A 3ucbA-2hruA:
undetectable		 3ucbA-2hruA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 12 LEU A 306
VAL A 231
ILE A 219
LEU A 223
VAL A 226
 None
 1.07A 3w68C-2hruA:
undetectable		 3w68C-2hruA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		6 / 12 LEU A 306
VAL A 231
ILE A 129
ILE A 219
LEU A 223
VAL A 226
 None
 1.33A 3w68D-2hruA:
undetectable		 3w68D-2hruA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 12 VAL A 231
ILE A 297
ILE A  92
GLU A 215
VAL A 176
 None
 1.31A 4a97B-2hruA:
undetectable
4a97C-2hruA:
undetectable		 4a97B-2hruA:
20.68
4a97C-2hruA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		4 / 7 ASP A 107
GLY A 136
VAL A 152
HIS A 375
 None
 0.92A 4c5nA-2hruA:
undetectable		 4c5nA-2hruA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 12 GLU A 425
ILE A 353
GLY A 418
ARG A 139
ILE A 421
 None
 1.41A 4djfA-2hruA:
undetectable		 4djfA-2hruA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		4 / 6 LEU A 402
LEU A 153
ILE A  91
THR A 441
 None
 0.89A 4do3B-2hruA:
undetectable		 4do3B-2hruA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_A_LYAA304_1
(FOLATE RECEPTOR BETA)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 12 ASP A 409
SER A 470
HIS A 405
GLY A 497
SER A 549
 None
 1.04A 4kn2A-2hruA:
undetectable		 4kn2A-2hruA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 9 LEU A 153
VAL A  88
ILE A  92
ILE A  91
GLY A 156
 None
 1.06A 4kukA-2hruA:
undetectable		 4kukA-2hruA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 12 LEU A 218
PHE A 178
ALA A 234
ILE A 297
VAL A 226
 None
 0.99A 4nkxA-2hruA:
undetectable		 4nkxA-2hruA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 12 LEU A 218
PHE A 178
ALA A 234
ILE A 297
VAL A 226
 None
 0.98A 4nkxC-2hruA:
undetectable		 4nkxC-2hruA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 12 LEU A 218
PHE A 178
ALA A 234
ILE A 297
VAL A 226
 None
 0.98A 4nkxD-2hruA:
undetectable		 4nkxD-2hruA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		4 / 6 GLU A 283
ASP A 236
ASP A  94
GLU A  70
 None
MG  A 902 ( 3.1A)
ADP  A2005 (-2.8A)
MG  A 901 ( 2.8A)
 1.20A 4ntxA-2hruA:
undetectable
4ntxC-2hruA:
undetectable		 4ntxA-2hruA:
22.93
4ntxC-2hruA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		3 / 3 PRO A 572
LEU A 571
HIS A 556
 None
 0.63A 4pevA-2hruA:
undetectable		 4pevA-2hruA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 12 ALA A  72
ALA A 123
ILE A 122
GLY A  90
GLN A 282
 None
 1.22A 4r38C-2hruA:
undetectable		 4r38C-2hruA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 12 ALA A  72
ALA A 123
ILE A 122
GLY A  90
GLN A 282
 None
 1.22A 4r38D-2hruA:
undetectable		 4r38D-2hruA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		3 / 3 ARG A  93
TYR A 125
GLU A 215
 None
 0.60A 4zzbE-2hruA:
undetectable		 4zzbE-2hruA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		4 / 5 ALA A 408
HIS A 405
ALA A 422
GLU A 137
 None
 1.36A 5a06C-2hruA:
undetectable
5a06D-2hruA:
undetectable		 5a06C-2hruA:
21.77
5a06D-2hruA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		4 / 6 ALA A 104
THR A 103
VAL A 131
VAL A  95
 None
 0.82A 5eckA-2hruA:
undetectable		 5eckA-2hruA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		4 / 6 ALA A 104
THR A 103
VAL A 131
VAL A  95
 None
 0.84A 5eckD-2hruA:
undetectable		 5eckD-2hruA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		4 / 6 ALA A 104
THR A 103
VAL A 131
VAL A  95
 None
 0.86A 5eclD-2hruA:
1.0		 5eclD-2hruA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 7 LEU A 402
GLY A 135
GLY A 136
THR A 133
ALA A 104
 None
 1.23A 5o96C-2hruA:
undetectable		 5o96C-2hruA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 12 GLY A 241
GLY A 240
VAL A  27
GLN A 282
GLY A 186
 None
 1.15A 6gneA-2hruA:
undetectable		 6gneA-2hruA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		5 / 12 GLY A 241
GLY A 240
VAL A  27
GLN A 282
GLY A 186
 None
 1.16A 6gneB-2hruA:
undetectable		 6gneB-2hruA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II
(Thermotoga
maritima) 		4 / 6 GLY A  89
THR A  86
ARG A 284
SER A 281
 None
 1.07A 6jogA-2hruA:
undetectable		 6jogA-2hruA:
15.00