SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hrv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 2hrv 2A CYSTEINE
PROTEINASE
(Rhinovirus
A) 		4 / 6 GLN A  91
ASP A  35
VAL A 120
HIS A  18
 None
 1.35A 1ekjG-2hrvA:
undetectable
1ekjH-2hrvA:
undetectable		 1ekjG-2hrvA:
19.18
1ekjH-2hrvA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 2hrv 2A CYSTEINE
PROTEINASE
(Rhinovirus
A) 		3 / 3 CYH A  54
ARG A 134
CYH A 112
 ZN  A 143 (-2.3A)
None
ZN  A 143 (-2.4A)
 1.13A 1p9gA-2hrvA:
undetectable		 1p9gA-2hrvA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 2hrv 2A CYSTEINE
PROTEINASE
(Rhinovirus
A) 		4 / 8 THR A  41
GLY A  45
ASP A  47
ILE A  13
 None
 0.98A 2f9wA-2hrvA:
undetectable
2f9wB-2hrvA:
undetectable		 2f9wA-2hrvA:
19.78
2f9wB-2hrvA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2hrv 2A CYSTEINE
PROTEINASE
(Rhinovirus
A) 		4 / 7 GLY A 108
ASP A 132
LEU A 133
ARG A 134
 None
 0.61A 2uyqA-2hrvA:
undetectable		 2uyqA-2hrvA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2hrv 2A CYSTEINE
PROTEINASE
(Rhinovirus
A) 		4 / 8 THR A  55
ASP A 132
LEU A  95
ASP A  76
 None
 1.07A 2zw9A-2hrvA:
undetectable		 2zw9A-2hrvA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2hrv 2A CYSTEINE
PROTEINASE
(Rhinovirus
A) 		5 / 7 GLY A 107
ILE A 131
GLY A 118
LEU A 133
ILE A  28
 None
 1.12A 5vkqA-2hrvA:
undetectable
5vkqB-2hrvA:
undetectable		 5vkqA-2hrvA:
6.11
5vkqB-2hrvA:
6.11