SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hrz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		5 / 10 GLY A  15
LEU A  76
THR A 110
LEU A 113
HIS A  86
 None
 1.47A 1a8uB-2hrzA:
3.1		 1a8uB-2hrzA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		5 / 10 GLY A 242
PHE A 238
LEU A  24
THR A 133
LEU A  87
 None
 1.50A 1a8uB-2hrzA:
3.1		 1a8uB-2hrzA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		5 / 12 ALA A 116
ALA A  73
LEU A  67
ILE A  84
ILE A  14
 None
 0.92A 1fk6A-2hrzA:
undetectable		 1fk6A-2hrzA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		5 / 12 ILE A 189
LEU A  87
HIS A 227
ILE A 184
PHE A 303
 None
 1.23A 1fmlB-2hrzA:
undetectable		 1fmlB-2hrzA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		5 / 12 GLU A 210
ILE A 191
ILE A 323
ALA A 280
ARG A 209
 None
 1.47A 1ki7B-2hrzA:
undetectable		 1ki7B-2hrzA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		4 / 6 PHE A  42
HIS A  10
ALA A  59
GLY A  58
 None
 1.00A 1l7xA-2hrzA:
3.1		 1l7xA-2hrzA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		4 / 7 PHE A 238
ALA A 315
ILE A 189
GLU A 316
 None
 0.91A 1oniD-2hrzA:
undetectable
1oniF-2hrzA:
undetectable		 1oniD-2hrzA:
15.27
1oniF-2hrzA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		4 / 8 ALA A  89
ILE A  90
CYH A 166
PHE A 132
 None
 0.81A 1sv9A-2hrzA:
undetectable		 1sv9A-2hrzA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		5 / 9 THR A 133
LEU A 239
VAL A 236
GLY A 237
ILE A 189
 None
 1.35A 2a1oB-2hrzA:
undetectable		 2a1oB-2hrzA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		3 / 3 ARG A 285
VAL A 213
GLY A 194
 None
 0.66A 2avvE-2hrzA:
undetectable		 2avvE-2hrzA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		3 / 3 ALA A 164
THR A 153
PHE A 132
 None
 0.71A 2c6nB-2hrzA:
undetectable		 2c6nB-2hrzA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		5 / 12 SER A 135
ILE A 136
ALA A 137
TYR A 159
THR A 188
 None
 0.76A 2japA-2hrzA:
16.4		 2japA-2hrzA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		5 / 12 SER A 135
ILE A 136
ALA A 137
TYR A 159
THR A 188
 None
 0.79A 2japB-2hrzA:
16.4		 2japB-2hrzA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		5 / 12 SER A 135
ILE A 136
ALA A 137
TYR A 159
THR A 188
 None
 0.79A 2japC-2hrzA:
5.6		 2japC-2hrzA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		5 / 12 SER A 135
ILE A 136
ALA A 137
TYR A 159
THR A 188
 None
 0.81A 2japD-2hrzA:
16.4		 2japD-2hrzA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		3 / 3 LEU A 143
PRO A 144
ARG A 185
 None
 0.51A 2qd4B-2hrzA:
3.3		 2qd4B-2hrzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		3 / 3 LEU A 143
PRO A 144
ARG A 185
 None
 0.55A 2qd5A-2hrzA:
undetectable		 2qd5A-2hrzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		3 / 3 LEU A 256
ARG A 254
ILE A 184
 None
 0.68A 2xn5B-2hrzA:
undetectable		 2xn5B-2hrzA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		5 / 12 LEU A  44
ILE A  11
LEU A  34
ILE A  13
PHE A  42
 None
 1.02A 2ygqA-2hrzA:
undetectable		 2ygqA-2hrzA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		3 / 3 MET A 258
GLU A 316
ASP A 329
 None
 1.01A 3a25A-2hrzA:
3.4		 3a25A-2hrzA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		5 / 12 THR A 133
ILE A  13
ALA A  12
VAL A  39
LEU A  28
 None
 1.10A 3a51E-2hrzA:
undetectable		 3a51E-2hrzA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		4 / 6 PHE A  42
HIS A  10
ALA A  59
GLY A  58
 None
 1.02A 3dd1B-2hrzA:
2.6		 3dd1B-2hrzA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		5 / 12 PHE A  85
LEU A  24
GLY A  15
GLY A  21
LEU A  67
 None
 1.40A 3dh0A-2hrzA:
3.9		 3dh0A-2hrzA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		5 / 11 GLY A  15
GLY A  18
ILE A  45
VAL A  47
ASP A  66
 None
 0.98A 3dxyA-2hrzA:
4.1		 3dxyA-2hrzA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		3 / 3 LYS A  37
ILE A 117
PHE A 178
 None
 0.99A 3j7zS-2hrzA:
undetectable
3j7za-2hrzA:
undetectable		 3j7zS-2hrzA:
15.70
3j7za-2hrzA:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		4 / 6 GLY A  35
GLY A  36
SER A  33
LEU A   4
 None
 0.80A 3o9mB-2hrzA:
undetectable		 3o9mB-2hrzA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		4 / 5 PHE A 151
ILE A 147
GLY A 140
HIS A 152
 None
 1.36A 3r0lD-2hrzA:
undetectable		 3r0lD-2hrzA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		3 / 3 ARG A 118
ARG A 176
ILE A 119
 None
 0.88A 4b7qC-2hrzA:
undetectable		 4b7qC-2hrzA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		4 / 5 ILE A  11
ALA A 243
MET A   9
PHE A  85
 None
 1.10A 4dc3B-2hrzA:
2.7		 4dc3B-2hrzA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		5 / 10 ALA A  79
PRO A 128
ILE A 117
LEU A 113
ILE A  84
 None
 1.18A 4dtaA-2hrzA:
undetectable		 4dtaA-2hrzA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		4 / 5 TYR A 159
GLY A 160
THR A 161
GLY A 312
 None
 0.70A 5jlcA-2hrzA:
undetectable		 5jlcA-2hrzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Agrobacterium
fabrum) 		5 / 8 ILE A  13
ALA A  12
VAL A 130
PHE A 132
VAL A 131
 None
 1.17A 5l94A-2hrzA:
undetectable		 5l94A-2hrzA:
23.83