SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hs5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2hs5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR GNTR
(Rhodococcus
jostii) 		5 / 12 ASP A 148
LEU A 219
HIS A 152
PHE A 179
ILE A 149
 ACT  A 238 (-2.7A)
None
ACT  A 238 (-3.8A)
ACT  A 238 (-4.9A)
None
 1.29A 1uobA-2hs5A:
undetectable		 1uobA-2hs5A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2hs5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR GNTR
(Rhodococcus
jostii) 		3 / 3 ARG A 104
HIS A 152
TYR A 101
 ACT  A 238 (-3.0A)
ACT  A 238 (-3.8A)
ACT  A 238 (-4.4A)
 1.26A 4fu8A-2hs5A:
undetectable		 4fu8A-2hs5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2hs5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR GNTR
(Rhodococcus
jostii) 		3 / 3 ARG A 104
HIS A 152
TYR A 101
 ACT  A 238 (-3.0A)
ACT  A 238 (-3.8A)
ACT  A 238 (-4.4A)
 1.22A 4fu9A-2hs5A:
undetectable		 4fu9A-2hs5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 2hs5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR GNTR
(Rhodococcus
jostii) 		3 / 3 VAL A  61
SER A  62
THR A  65
 None
 0.48A 4luhA-2hs5A:
4.5		 4luhA-2hs5A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 2hs5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR GNTR
(Rhodococcus
jostii) 		4 / 8 GLY A 190
TYR A 101
ASP A 148
ASP A 133
 None
ACT  A 238 (-4.4A)
ACT  A 238 (-2.7A)
None
 0.85A 5vlmB-2hs5A:
undetectable		 5vlmB-2hs5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 2hs5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR GNTR
(Rhodococcus
jostii) 		4 / 7 GLY A 190
TYR A 101
ASP A 148
ASP A 133
 None
ACT  A 238 (-4.4A)
ACT  A 238 (-2.7A)
None
 0.97A 5vlmE-2hs5A:
1.5		 5vlmE-2hs5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 2hs5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR GNTR
(Rhodococcus
jostii) 		5 / 11 VAL A 144
GLY A 145
ALA A 132
LEU A 193
ASN A 196
 None
 0.99A 5x6yA-2hs5A:
undetectable		 5x6yA-2hs5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 2hs5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR GNTR
(Rhodococcus
jostii) 		5 / 10 VAL A 144
GLY A 145
ALA A 132
LEU A 193
ASN A 196
 None
 0.99A 5x6yB-2hs5A:
undetectable		 5x6yB-2hs5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 2hs5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR GNTR
(Rhodococcus
jostii) 		5 / 11 VAL A 144
GLY A 145
ALA A 132
LEU A 193
ASN A 196
 None
 0.94A 5x6yC-2hs5A:
undetectable		 5x6yC-2hs5A:
15.95