SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hsi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 2hsi PUTATIVE PEPTIDASE
M23
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 100
GLY A  37
LEU A  30
ALA A 274
LEU A  31
 None
 1.39A 1jipA-2hsiA:
undetectable		 1jipA-2hsiA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 2hsi PUTATIVE PEPTIDASE
M23
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 217
SER A 145
LEU A  61
GLY A 221
 None
 1.17A 2j2pA-2hsiA:
undetectable
2j2pB-2hsiA:
undetectable		 2j2pA-2hsiA:
21.58
2j2pB-2hsiA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2hsi PUTATIVE PEPTIDASE
M23
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 218
SER A 224
VAL A 214
LEU A 229
ILE A 193
 None
 1.49A 2xrlA-2hsiA:
undetectable		 2xrlA-2hsiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2hsi PUTATIVE PEPTIDASE
M23
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 139
ARG A 142
LYS A  58
 None
 1.00A 3kp3B-2hsiA:
undetectable		 3kp3B-2hsiA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2hsi PUTATIVE PEPTIDASE
M23
(Pseudomonas
aeruginosa) 		4 / 5 SER A  79
GLY A  57
GLU A  97
GLU A  88
 None
 1.23A 3raeB-2hsiA:
undetectable
3raeD-2hsiA:
undetectable		 3raeB-2hsiA:
21.05
3raeD-2hsiA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2hsi PUTATIVE PEPTIDASE
M23
(Pseudomonas
aeruginosa) 		4 / 8 PRO A 149
LEU A 152
VAL A  39
VAL A 264
 None
 1.03A 4pwdA-2hsiA:
undetectable		 4pwdA-2hsiA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 2hsi PUTATIVE PEPTIDASE
M23
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 259
ASP A 184
HIS A 180
 ZN  A 283 (-3.6A)
ZN  A 283 (-2.2A)
ZN  A 283 (-3.4A)
 0.64A 5oexA-2hsiA:
undetectable		 5oexA-2hsiA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 2hsi PUTATIVE PEPTIDASE
M23
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 259
ASP A 184
HIS A 180
 ZN  A 283 (-3.6A)
ZN  A 283 (-2.2A)
ZN  A 283 (-3.4A)
 0.67A 5oexB-2hsiA:
undetectable		 5oexB-2hsiA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 2hsi PUTATIVE PEPTIDASE
M23
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 259
ASP A 184
HIS A 180
 ZN  A 283 (-3.6A)
ZN  A 283 (-2.2A)
ZN  A 283 (-3.4A)
 0.65A 5oexC-2hsiA:
1.4		 5oexC-2hsiA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 2hsi PUTATIVE PEPTIDASE
M23
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 259
ASP A 184
HIS A 180
 ZN  A 283 (-3.6A)
ZN  A 283 (-2.2A)
ZN  A 283 (-3.4A)
 0.67A 5oexD-2hsiA:
undetectable		 5oexD-2hsiA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2hsi PUTATIVE PEPTIDASE
M23
(Pseudomonas
aeruginosa) 		4 / 7 ILE A  27
LEU A  31
ARG A  64
LEU A  61
 None
 0.97A 5xdqA-2hsiA:
undetectable
5xdqJ-2hsiA:
undetectable		 5xdqA-2hsiA:
19.60
5xdqJ-2hsiA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)		 2hsi PUTATIVE PEPTIDASE
M23
(Pseudomonas
aeruginosa) 		5 / 11 GLY A  37
TYR A  55
ASN A 267
PHE A 100
GLY A  38
 None
 1.40A 5yjsA-2hsiA:
0.0		 5yjsA-2hsiA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)		 2hsi PUTATIVE PEPTIDASE
M23
(Pseudomonas
aeruginosa) 		5 / 11 PHE A 166
GLY A  37
VAL A  39
PHE A 276
GLY A  38
 None
 1.47A 5yjsA-2hsiA:
0.0		 5yjsA-2hsiA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 2hsi PUTATIVE PEPTIDASE
M23
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 216
VAL A 214
ILE A 193
PHE A 226
 None
 0.73A 5ywmX-2hsiA:
undetectable		 5ywmX-2hsiA:
15.60