SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hsj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2hsj PUTATIVE PLATELET
ACTIVATING FACTOR
(Streptococcus
pneumoniae) 		4 / 6 TYR A  21
ILE A  34
ASN A  59
LEU A  47
 None
 1.36A 2wekB-2hsjA:
undetectable		 2wekB-2hsjA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 2hsj PUTATIVE PLATELET
ACTIVATING FACTOR
(Streptococcus
pneumoniae) 		4 / 4 VAL A 115
ARG A  60
ILE A  90
THR A 122
 None
None
None
GOL  A1409 (-3.8A)
 0.99A 3cl9A-2hsjA:
undetectable		 3cl9A-2hsjA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 2hsj PUTATIVE PLATELET
ACTIVATING FACTOR
(Streptococcus
pneumoniae) 		4 / 7 GLN A 151
ASN A 152
TRP A 153
ILE A  95
 None
 1.17A 4ii8A-2hsjA:
undetectable		 4ii8A-2hsjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 2hsj PUTATIVE PLATELET
ACTIVATING FACTOR
(Streptococcus
pneumoniae) 		4 / 5 GLN A  18
ILE A  62
ILE A  37
TYR A  65
 None
 1.21A 5dnuA-2hsjA:
3.7		 5dnuA-2hsjA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2hsj PUTATIVE PLATELET
ACTIVATING FACTOR
(Streptococcus
pneumoniae) 		4 / 8 GLY A  91
THR A  67
LEU A 108
LEU A 160
 None
 0.74A 5hs1A-2hsjA:
undetectable		 5hs1A-2hsjA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2hsj PUTATIVE PLATELET
ACTIVATING FACTOR
(Streptococcus
pneumoniae) 		3 / 3 ALA A 104
ASN A 107
LEU A 108
 None
 0.46A 5i1oA-2hsjA:
undetectable		 5i1oA-2hsjA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2hsj PUTATIVE PLATELET
ACTIVATING FACTOR
(Streptococcus
pneumoniae) 		3 / 3 LYS A  20
LEU A  24
ARG A  60
 None
 0.89A 5yw0A-2hsjA:
undetectable		 5yw0A-2hsjA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2hsj PUTATIVE PLATELET
ACTIVATING FACTOR
(Streptococcus
pneumoniae) 		5 / 12 GLY A 198
GLN A 200
SER A 203
LEU A  47
ILE A  41
 None
 1.35A 6md4A-2hsjA:
undetectable		 6md4A-2hsjA:
15.38