SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hsm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 129
LEU A 130
GLY A 132
ALA A 137
ALA A 138
VAL A  97
 None
 1.26A 2oc8A-2hsmA:
undetectable		 2oc8A-2hsmA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 130
ILE A  84
ILE A  51
PHE A  85
VAL A  97
 None
 1.11A 2ygnA-2hsmA:
undetectable		 2ygnA-2hsmA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		4 / 8 GLU A  36
SER A 148
VAL A 105
ALA A 141
 None
 0.95A 3ax7A-2hsmA:
undetectable		 3ax7A-2hsmA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		4 / 8 GLU A  36
SER A 148
VAL A 105
ALA A 141
 None
 0.92A 3ax9A-2hsmA:
undetectable		 3ax9A-2hsmA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  83
PHE A  85
SER A  50
ILE A  51
ILE A  42
 None
 1.19A 3clbB-2hsmA:
undetectable		 3clbB-2hsmA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_A_AG2A1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		5 / 9 TRP A  96
ASP A 139
SER A 136
GLY A 132
LEU A 119
 None
 1.30A 3n2oA-2hsmA:
2.6
3n2oB-2hsmA:
2.5		 3n2oA-2hsmA:
15.54
3n2oB-2hsmA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  73
LEU A  23
VAL A 140
GLY A 144
ALA A  35
 None
 0.98A 3pghC-2hsmA:
undetectable		 3pghC-2hsmA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  73
LEU A  23
VAL A 140
GLY A 144
ALA A  35
 None
 1.02A 3rr3A-2hsmA:
1.3		 3rr3A-2hsmA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  73
LEU A  23
VAL A 140
GLY A 144
ALA A  35
 None
 1.01A 3rr3B-2hsmA:
undetectable		 3rr3B-2hsmA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  73
LEU A  23
VAL A 140
GLY A 144
ALA A  35
 None
 1.02A 3rr3C-2hsmA:
undetectable		 3rr3C-2hsmA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  73
LEU A  23
VAL A 140
GLY A 144
ALA A  35
 None
 1.02A 3rr3D-2hsmA:
undetectable		 3rr3D-2hsmA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 149
ALA A 145
LEU A 119
LEU A 116
 None
 0.89A 4ejgB-2hsmA:
undetectable		 4ejgB-2hsmA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		4 / 7 ASN A 149
ALA A 145
LEU A 119
LEU A 116
 None
 0.90A 4ejgC-2hsmA:
undetectable		 4ejgC-2hsmA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  84
ALA A  39
SER A  21
PRO A  20
ASN A  49
 None
 1.28A 4gh8B-2hsmA:
undetectable		 4gh8B-2hsmA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  51
LEU A  23
ILE A 176
ALA A  33
 None
 0.81A 6b5vA-2hsmA:
undetectable
6b5vC-2hsmA:
undetectable		 6b5vA-2hsmA:
17.70
6b5vC-2hsmA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		4 / 7 ALA A  33
ILE A  51
LEU A  23
ILE A 176
 None
 0.85A 6b5vA-2hsmA:
undetectable
6b5vB-2hsmA:
undetectable		 6b5vA-2hsmA:
17.70
6b5vB-2hsmA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  51
LEU A  23
ILE A 176
ALA A  33
 None
 0.81A 6b5vC-2hsmA:
undetectable
6b5vD-2hsmA:
undetectable		 6b5vC-2hsmA:
17.70
6b5vD-2hsmA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		4 / 7 ALA A  33
ILE A  51
LEU A  23
ILE A 176
 None
 0.81A 6b5vB-2hsmA:
undetectable
6b5vD-2hsmA:
undetectable		 6b5vB-2hsmA:
17.70
6b5vD-2hsmA:
17.70