SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hsn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 2hsn GU4 NUCLEIC-BINDING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 VAL B  52
PHE B  58
THR B  68
TRP B  33
 None
 1.44A 2q6oB-2hsnB:
undetectable		 2q6oB-2hsnB:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 2hsn METHIONYL-TRNA
SYNTHETASE,
CYTOPLASMIC
GU4 NUCLEIC-BINDING
PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 SER A   4
ASP B  55
ASN B  56
 None
 0.99A 3lsfB-2hsnA:
undetectable
3lsfE-2hsnA:
undetectable		 3lsfB-2hsnA:
20.46
3lsfE-2hsnA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2hsn METHIONYL-TRNA
SYNTHETASE,
CYTOPLASMIC
GU4 NUCLEIC-BINDING
PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 TYR A  94
SER B  39
LEU A  86
VAL B  75
VAL B  72
 None
 1.00A 3w68B-2hsnA:
undetectable		 3w68B-2hsnA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2hsn GU4 NUCLEIC-BINDING
PROTEIN 1
METHIONYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  58
TYR A  69
GLN B  26
PHE A  74
 None
 1.40A 4grqA-2hsnA:
undetectable
4grqC-2hsnA:
undetectable		 4grqA-2hsnA:
21.38
4grqC-2hsnA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2hsn GU4 NUCLEIC-BINDING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 ILE B 104
LEU B 110
ILE B  15
PHE B  73
 None
 0.87A 4r38D-2hsnB:
undetectable		 4r38D-2hsnB:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2hsn METHIONYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		4 / 4 GLU A  41
PRO A  40
ILE A   7
LEU A   6
 None
 1.04A 5m45A-2hsnA:
undetectable		 5m45A-2hsnA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2hsn METHIONYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		4 / 4 GLU A  41
PRO A  40
ILE A   7
LEU A   6
 None
 1.08A 5m45D-2hsnA:
undetectable		 5m45D-2hsnA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2hsn METHIONYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		4 / 4 GLU A  41
PRO A  40
ILE A   7
LEU A   6
 None
 1.03A 5m45G-2hsnA:
undetectable		 5m45G-2hsnA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2hsn METHIONYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		4 / 4 GLU A  41
PRO A  40
ILE A   7
LEU A   6
 None
 1.10A 5m45J-2hsnA:
undetectable		 5m45J-2hsnA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 2hsn GU4 NUCLEIC-BINDING
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 9 VAL B  52
HIS B  99
LEU B  37
VAL B  70
ASP B  69
 None
 1.46A 6c2mD-2hsnB:
undetectable		 6c2mD-2hsnB:
20.49