SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hst'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2hst EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Homo
sapiens) 		3 / 3 LEU A 212
PHE A 158
ARG A 203
 None
 0.86A 1xdkB-2hstA:
undetectable		 1xdkB-2hstA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2hst EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Homo
sapiens) 		3 / 3 LEU A 212
PHE A 158
ARG A 203
 None
 0.86A 1xdkF-2hstA:
undetectable		 1xdkF-2hstA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 2hst EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Homo
sapiens) 		4 / 4 GLY A 228
VAL A 150
GLY A 155
THR A 173
 None
 0.76A 3ib2A-2hstA:
undetectable		 3ib2A-2hstA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2hst EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Homo
sapiens) 		5 / 11 GLN A 162
GLU A 167
THR A 165
PHE A 146
GLY A 147
 None
 1.45A 3wg7A-2hstA:
undetectable
3wg7B-2hstA:
1.1
3wg7T-2hstA:
0.0		 3wg7A-2hstA:
13.77
3wg7B-2hstA:
18.10
3wg7T-2hstA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 2hst EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Homo
sapiens) 		4 / 6 LEU A 157
LEU A 169
VAL A 168
PHE A 158
 None
 1.02A 4uswA-2hstA:
undetectable		 4uswA-2hstA:
16.01