SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hsz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 2hsz NOVEL PREDICTED
PHOSPHATASE
(Histophilus
somni) 		5 / 12 SER A  18
ASP A  10
LEU A 194
TYR A 196
LEU A 104
 None
 1.39A 1e7wA-2hszA:
5.9		 1e7wA-2hszA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 2hsz NOVEL PREDICTED
PHOSPHATASE
(Histophilus
somni) 		5 / 12 GLY A  87
VAL A 125
ALA A  51
LEU A  54
PHE A  82
 None
None
UNL  A 227 (-3.6A)
UNL  A 227 ( 4.9A)
UNL  A 227 (-3.8A)
 1.09A 1gs4A-2hszA:
undetectable		 1gs4A-2hszA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YDA_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 2hsz NOVEL PREDICTED
PHOSPHATASE
(Histophilus
somni) 		5 / 10 VAL A 174
PHE A 216
VAL A 192
THR A 223
TRP A 211
 None
 1.33A 1ydaA-2hszA:
undetectable		 1ydaA-2hszA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2hsz NOVEL PREDICTED
PHOSPHATASE
(Histophilus
somni) 		5 / 12 LEU A  15
GLY A 175
ASP A 210
ASP A  10
ALA A 184
 None
 1.16A 2br4E-2hszA:
3.0		 2br4E-2hszA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 2hsz NOVEL PREDICTED
PHOSPHATASE
(Histophilus
somni) 		5 / 12 GLY A  87
VAL A 125
ALA A  51
LEU A  54
PHE A  82
 None
None
UNL  A 227 (-3.6A)
UNL  A 227 ( 4.9A)
UNL  A 227 (-3.8A)
 0.94A 2oz7A-2hszA:
undetectable		 2oz7A-2hszA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2hsz NOVEL PREDICTED
PHOSPHATASE
(Histophilus
somni) 		4 / 6 THR A 103
LEU A 220
VAL A 174
VAL A 192
 None
 0.98A 2z97A-2hszA:
undetectable		 2z97A-2hszA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2hsz NOVEL PREDICTED
PHOSPHATASE
(Histophilus
somni) 		5 / 12 GLY A 175
GLY A 193
PHE A 213
THR A  14
LEU A 104
 None
 0.86A 4n49A-2hszA:
2.1		 4n49A-2hszA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2hsz NOVEL PREDICTED
PHOSPHATASE
(Histophilus
somni) 		4 / 5 TYR A  97
LEU A  22
PRO A  20
LEU A  11
 None
UNL  A 227 (-4.8A)
None
None
 1.46A 5eshA-2hszA:
undetectable		 5eshA-2hszA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 2hsz NOVEL PREDICTED
PHOSPHATASE
(Histophilus
somni) 		4 / 7 PHE A   9
ILE A 219
LEU A 194
GLY A 193
 None
 0.81A 5h3aB-2hszA:
undetectable		 5h3aB-2hszA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2hsz NOVEL PREDICTED
PHOSPHATASE
(Histophilus
somni) 		4 / 6 LEU A 114
VAL A 116
THR A 118
LEU A 104
 None
 0.94A 5tudD-2hszA:
undetectable		 5tudD-2hszA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 2hsz NOVEL PREDICTED
PHOSPHATASE
(Histophilus
somni) 		4 / 8 GLY A 197
ILE A  47
ASP A  12
ASP A 180
 None
None
UNL  A 227 ( 4.6A)
None
 1.03A 5vlmH-2hszA:
undetectable		 5vlmH-2hszA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 2hsz NOVEL PREDICTED
PHOSPHATASE
(Histophilus
somni) 		4 / 6 PHE A   9
ILE A 219
LEU A 194
GLY A 193
 None
 0.93A 5x5qE-2hszA:
undetectable		 5x5qE-2hszA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2hsz NOVEL PREDICTED
PHOSPHATASE
(Histophilus
somni) 		3 / 3 LYS A 120
PRO A 121
LYS A 123
 UNL  A 227 (-3.0A)
UNL  A 227 (-4.2A)
UNL  A 227 (-3.7A)
 1.22A 5y9yA-2hszA:
undetectable		 5y9yA-2hszA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B50_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 2hsz NOVEL PREDICTED
PHOSPHATASE
(Histophilus
somni) 		5 / 12 LEU A 147
VAL A 116
VAL A 117
ASP A 180
THR A  14
 None
 1.30A 6b50A-2hszA:
1.4		 6b50A-2hszA:
22.71