SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ht6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2ht6 GTP-BINDING PROTEIN
GEM
(Homo
sapiens) 		5 / 12 PHE A 232
THR A 220
GLY A 234
ILE A 218
VAL A 239
 None
 1.26A 1vq1A-2ht6A:
undetectable		 1vq1A-2ht6A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 2ht6 GTP-BINDING PROTEIN
GEM
(Homo
sapiens) 		5 / 9 VAL A  86
GLY A  82
LEU A 154
LEU A 129
ASP A 131
 GDP  A 545 (-4.1A)
None
None
None
MG  A 344 ( 4.1A)
 0.94A 2j2pB-2ht6A:
undetectable
2j2pC-2ht6A:
undetectable		 2j2pB-2ht6A:
21.43
2j2pC-2ht6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ht6 GTP-BINDING PROTEIN
GEM
(Homo
sapiens) 		4 / 5 GLY A  87
LEU A 129
LEU A 231
LEU A 171
 GDP  A 545 (-3.3A)
None
None
None
 0.84A 4o8fA-2ht6A:
undetectable		 4o8fA-2ht6A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2ht6 GTP-BINDING PROTEIN
GEM
(Homo
sapiens) 		4 / 6 VAL A 236
ARG A 116
VAL A  78
PHE A  95
 None
 1.49A 5adeA-2ht6A:
undetectable
5adeB-2ht6A:
undetectable		 5adeA-2ht6A:
18.25
5adeB-2ht6A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2ht6 GTP-BINDING PROTEIN
GEM
(Homo
sapiens) 		4 / 6 VAL A 236
PRO A 185
ALA A 125
THR A  74
 None
 0.96A 6cduB-2ht6A:
undetectable
6cduC-2ht6A:
undetectable		 6cduB-2ht6A:
20.85
6cduC-2ht6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2ht6 GTP-BINDING PROTEIN
GEM
(Homo
sapiens) 		4 / 7 VAL A 236
PRO A 185
ALA A 125
THR A  74
 None
 0.99A 6cduC-2ht6A:
undetectable
6cduD-2ht6A:
undetectable		 6cduC-2ht6A:
20.85
6cduD-2ht6A:
20.85