SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2htb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE
(Salmonella
enterica) 		5 / 12 LEU A  61
PHE A  67
GLN A  22
LEU A   8
VAL A  30
 None
 1.32A 1u72A-2htbA:
undetectable		 1u72A-2htbA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE
(Salmonella
enterica) 		4 / 8 ASP A 208
TYR A 166
HIS A  95
HIS A 164
 None
 1.37A 2bteD-2htbA:
undetectable		 2bteD-2htbA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE
(Salmonella
enterica) 		4 / 6 LEU A 196
TYR A 211
ILE A 200
GLY A 241
 None
 0.91A 2du8A-2htbA:
undetectable		 2du8A-2htbA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE
(Salmonella
enterica) 		4 / 7 PHE A 141
LEU A 151
ALA A 139
PHE A 119
 None
 0.98A 2vcvL-2htbA:
undetectable		 2vcvL-2htbA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE
(Salmonella
enterica) 		3 / 3 VAL A 169
ASN A 243
TRP A 242
 None
 0.84A 2y00B-2htbA:
undetectable		 2y00B-2htbA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_A_CLMA221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE
(Salmonella
enterica) 		4 / 4 PHE A  84
ALA A 162
CYH A  80
HIS A  95
 None
 0.94A 3u9fB-2htbA:
0.0		 3u9fB-2htbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE
(Salmonella
enterica) 		3 / 3 PHE A  84
CYH A  80
HIS A  95
 None
 0.88A 3u9fF-2htbA:
undetectable		 3u9fF-2htbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE
(Salmonella
enterica) 		3 / 3 PHE A  84
CYH A  80
HIS A  95
 None
 0.86A 3u9fG-2htbA:
undetectable		 3u9fG-2htbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE
(Salmonella
enterica) 		3 / 3 PHE A  84
CYH A  80
HIS A  95
 None
 0.86A 3u9fL-2htbA:
undetectable		 3u9fL-2htbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE
(Salmonella
enterica) 		4 / 4 PHE A  84
ALA A 162
CYH A  80
HIS A  95
 None
 1.00A 3u9fR-2htbA:
0.0		 3u9fR-2htbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE
(Salmonella
enterica) 		3 / 3 PHE A  84
CYH A  80
HIS A  95
 None
 0.79A 3u9fS-2htbA:
undetectable		 3u9fS-2htbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE
(Salmonella
enterica) 		4 / 8 TRP A 242
PHE A 203
VAL A 177
TYR A 211
 None
 1.17A 4f5zA-2htbA:
undetectable		 4f5zA-2htbA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE
(Salmonella
enterica) 		4 / 7 ARG A 227
PRO A 244
SER A 249
VAL A 264
 None
 1.19A 4klrA-2htbA:
undetectable		 4klrA-2htbA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE
(Salmonella
enterica) 		4 / 5 LEU A 105
ASP A  27
ARG A  20
ILE A  11
 None
 1.45A 4mwrA-2htbA:
undetectable		 4mwrA-2htbA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE
(Salmonella
enterica) 		5 / 12 PHE A 141
ILE A  79
ALA A 139
VAL A 231
LEU A 163
 None
 1.40A 4qzuA-2htbA:
1.5		 4qzuA-2htbA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE
(Salmonella
enterica) 		4 / 8 HIS A  33
GLY A 144
VAL A  31
ASP A 111
 None
 0.78A 5f8yB-2htbA:
undetectable		 5f8yB-2htbA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE
(Salmonella
enterica) 		4 / 7 PHE A 167
ILE A 220
ASP A 171
GLY A 170
 None
 0.92A 5h3aA-2htbA:
undetectable		 5h3aA-2htbA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE
(Salmonella
enterica) 		4 / 5 GLN A 275
THR A 159
THR A 136
LEU A 151
 None
 1.30A 6aphA-2htbA:
undetectable		 6aphA-2htbA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_2
(-)		 2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE
(Salmonella
enterica) 		4 / 4 GLN A 275
THR A 159
THR A 136
LEU A 151
 None
 1.29A 6f3mC-2htbA:
undetectable		 6f3mC-2htbA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE
(Salmonella
enterica) 		4 / 5 GLN A 275
THR A 159
THR A 136
LEU A 151
 None
 1.31A 6gbnB-2htbA:
undetectable		 6gbnB-2htbA:
21.64