SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2htm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		4 / 7 ALA A 172
GLU A 169
LEU A 168
VAL A 183
 None
 0.93A 1hk2A-2htmA:
undetectable		 1hk2A-2htmA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWJ_A_CAMA418_0
(CYTOCHROME P450-CAM)		 2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		5 / 9 THR A  41
THR A 148
LEU A 205
VAL A 182
VAL A   6
 None
 1.41A 1iwjA-2htmA:
0.0		 1iwjA-2htmA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 2htm PUTATIVE THIAMINE
BIOSYNTHESIS PROTEIN
THIS
THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		5 / 12 GLN E  62
ASN A  69
ALA A  71
GLU A  98
ILE A 100
 None
 0.82A 1kxhA-2htmE:
undetectable		 1kxhA-2htmE:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		5 / 10 THR A  41
THR A 148
LEU A 205
VAL A 182
VAL A   6
 None
 1.45A 1o76A-2htmA:
undetectable		 1o76A-2htmA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		5 / 8 THR A  41
THR A 148
LEU A 205
VAL A 182
VAL A   6
 None
 1.40A 1t86A-2htmA:
undetectable		 1t86A-2htmA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		5 / 9 THR A  41
THR A 148
LEU A 205
VAL A 182
VAL A   6
 None
 1.39A 1t86B-2htmA:
0.0		 1t86B-2htmA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 2htm PUTATIVE THIAMINE
BIOSYNTHESIS PROTEIN
THIS
(Thermus
thermophilus) 		5 / 12 GLY E  41
VAL E  55
LEU E  16
MET E  23
LEU E   4
 None
 0.98A 1ya4C-2htmE:
undetectable		 1ya4C-2htmE:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		4 / 7 GLU A  30
ALA A  35
PRO A 217
ALA A 220
 None
 1.05A 2ejfA-2htmA:
undetectable		 2ejfA-2htmA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		5 / 11 ARG A 119
ALA A  73
THR A  70
GLU A 118
LEU A  97
 None
 1.33A 2v0mD-2htmA:
undetectable		 2v0mD-2htmA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		5 / 12 GLY A 186
GLY A 157
ALA A 209
LEU A 205
VAL A 204
 None
 0.94A 2yqzB-2htmA:
undetectable		 2yqzB-2htmA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		4 / 7 GLU A  30
ALA A  35
PRO A 217
ALA A 220
 None
 1.11A 2zgwA-2htmA:
undetectable		 2zgwA-2htmA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		4 / 6 GLU A  30
ALA A  35
PRO A 217
ALA A 220
 None
 1.09A 2zgwB-2htmA:
undetectable		 2zgwB-2htmA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2htm PUTATIVE THIAMINE
BIOSYNTHESIS PROTEIN
THIS
(Thermus
thermophilus) 		4 / 8 VAL E  19
VAL E  32
LEU E  34
VAL E  57
 None
 0.70A 2zujA-2htmE:
undetectable		 2zujA-2htmE:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		4 / 8 SER A  19
THR A  41
VAL A  42
LEU A  66
 None
 0.94A 3ax7A-2htmA:
undetectable		 3ax7A-2htmA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CAS_A_ASDA332_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		5 / 10 TYR A  22
SER A  13
VAL A  39
VAL A  64
LEU A  61
 None
 1.45A 3casA-2htmA:
6.1		 3casA-2htmA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		5 / 9 THR A  41
THR A 148
LEU A 205
VAL A 182
VAL A   6
 None
 1.46A 3cppA-2htmA:
0.0		 3cppA-2htmA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		4 / 4 LEU A  97
ASP A 134
VAL A 149
THR A 146
 None
 0.98A 3cyxB-2htmA:
undetectable		 3cyxB-2htmA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2htm PUTATIVE THIAMINE
BIOSYNTHESIS PROTEIN
THIS
(Thermus
thermophilus) 		5 / 10 VAL E  19
LEU E  34
VAL E  32
VAL E  55
LEU E  49
 None
 0.97A 3gwxA-2htmE:
undetectable		 3gwxA-2htmE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		5 / 9 THR A  41
THR A 148
LEU A 205
VAL A 182
VAL A   6
 None
 1.41A 4ek1B-2htmA:
0.0		 4ek1B-2htmA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		3 / 3 ARG A 173
LEU A 170
GLU A 174
 None
 0.65A 4l3gF-2htmA:
undetectable		 4l3gF-2htmA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		5 / 10 LEU A 205
VAL A  42
LEU A  61
LEU A  66
VAL A  64
 None
 1.21A 4po0A-2htmA:
undetectable		 4po0A-2htmA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		5 / 10 VAL A 196
GLU A 195
THR A 164
VAL A 183
LEU A 187
 None
 1.36A 4yb6C-2htmA:
undetectable
4yb6F-2htmA:
undetectable		 4yb6C-2htmA:
24.38
4yb6F-2htmA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		5 / 10 LEU A 187
VAL A 196
GLU A 195
THR A 164
VAL A 183
 None
 1.33A 4yb6A-2htmA:
undetectable
4yb6D-2htmA:
undetectable		 4yb6A-2htmA:
24.38
4yb6D-2htmA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2htm PUTATIVE THIAMINE
BIOSYNTHESIS PROTEIN
THIS
THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		5 / 7 ALA A  37
ASP A 184
GLY E  64
THR A  70
GLU A  98
 None
 1.48A 5bs8A-2htmA:
undetectable
5bs8C-2htmA:
undetectable
5bs8D-2htmA:
undetectable		 5bs8A-2htmA:
21.01
5bs8C-2htmA:
21.01
5bs8D-2htmA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2htm PUTATIVE THIAMINE
BIOSYNTHESIS PROTEIN
THIS
THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		5 / 7 ALA A  37
ASP A 184
GLY E  64
THR A  70
GLU A  98
 None
 1.44A 5btgA-2htmA:
undetectable
5btgC-2htmA:
undetectable
5btgD-2htmA:
undetectable		 5btgA-2htmA:
21.01
5btgC-2htmA:
21.01
5btgD-2htmA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		5 / 12 VAL A 196
ALA A 154
ALA A 153
VAL A 183
GLY A 157
 None
 1.06A 5igjA-2htmA:
undetectable		 5igjA-2htmA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		5 / 12 ILE A 121
VAL A  95
LEU A 144
THR A 113
LEU A 114
 None
 1.16A 6b54A-2htmA:
undetectable		 6b54A-2htmA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 2htm PUTATIVE THIAMINE
BIOSYNTHESIS PROTEIN
THIS
THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Thermus
thermophilus) 		4 / 5 TYR A  22
GLN E  62
GLY A 188
ILE A 210
 None
 1.40A 6debB-2htmA:
undetectable		 6debB-2htmA:
12.50