SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hu9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 2hu9 MERCURIC TRANSPORT
PROTEIN PERIPLASMIC
COMPONENT
(Archaeoglobus
fulgidus) 		3 / 3 VAL A  14
VAL A 110
TRP A  12
 None
 0.93A 1bdwA-2hu9A:
undetectable
1bdwB-2hu9A:
undetectable		 1bdwA-2hu9A:
9.82
1bdwB-2hu9A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 2hu9 MERCURIC TRANSPORT
PROTEIN PERIPLASMIC
COMPONENT
(Archaeoglobus
fulgidus) 		3 / 3 TRP A 121
VAL A 110
TRP A  12
 ACY  A 301 (-4.9A)
None
None
 1.00A 1c4dA-2hu9A:
undetectable
1c4dB-2hu9A:
undetectable		 1c4dA-2hu9A:
9.82
1c4dB-2hu9A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hu9 MERCURIC TRANSPORT
PROTEIN PERIPLASMIC
COMPONENT
(Archaeoglobus
fulgidus) 		4 / 4 GLY A 104
VAL A  80
PHE A  92
ILE A 100
 FES  A 131 (-3.5A)
None
None
None
 1.16A 4xv2B-2hu9A:
undetectable		 4xv2B-2hu9A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 2hu9 MERCURIC TRANSPORT
PROTEIN PERIPLASMIC
COMPONENT
(Archaeoglobus
fulgidus) 		4 / 8 THR A  61
TYR A  47
PHE A  37
TYR A  76
 None
 1.15A 5v4vA-2hu9A:
undetectable		 5v4vA-2hu9A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 2hu9 MERCURIC TRANSPORT
PROTEIN PERIPLASMIC
COMPONENT
(Archaeoglobus
fulgidus) 		4 / 8 THR A  61
TYR A  47
PHE A  37
TYR A  76
 None
 1.14A 5v4vB-2hu9A:
undetectable		 5v4vB-2hu9A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 2hu9 MERCURIC TRANSPORT
PROTEIN PERIPLASMIC
COMPONENT
(Archaeoglobus
fulgidus) 		4 / 5 TRP A 121
VAL A  74
GLU A  82
LEU A 126
 ACY  A 301 (-4.9A)
ACY  A 301 ( 4.9A)
None
None
 1.00A 5xooB-2hu9A:
undetectable		 5xooB-2hu9A:
14.39