SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2huf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQB_A_RTLA185_0
(RETINOL-BINDING
PROTEIN)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		5 / 10 LEU A 133
ALA A 110
VAL A 166
LEU A 140
HIS A 101
 None
 1.37A 1aqbA-2hufA:
0.0		 1aqbA-2hufA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		5 / 12 VAL A 166
LEU A 177
VAL A 123
ALA A 139
ILE A  97
 None
 1.03A 1epbB-2hufA:
undetectable		 1epbB-2hufA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		3 / 3 ARG A 108
GLY A 348
PRO A 349
 None
 0.76A 2hreD-2hufA:
undetectable		 2hreD-2hufA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		5 / 12 ILE A  57
GLY A 203
VAL A 182
SER A  28
PRO A 212
 None
None
LLP  A 206 ( 4.1A)
LLP  A 206 ( 2.6A)
None
 1.03A 2okcA-2hufA:
3.3		 2okcA-2hufA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		5 / 12 ILE A  57
GLY A 203
VAL A 182
SER A  28
PRO A 212
 None
None
LLP  A 206 ( 4.1A)
LLP  A 206 ( 2.6A)
None
 1.06A 2okcB-2hufA:
3.2		 2okcB-2hufA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		4 / 6 TRP A 105
SER A 109
ALA A 110
ASP A 107
 LLP  A 206 ( 3.5A)
None
None
None
 1.36A 3aruA-2hufA:
undetectable		 3aruA-2hufA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		4 / 8 TYR A 307
VAL A 354
VAL A 317
GLY A 346
 None
 0.84A 3hjoA-2hufA:
undetectable		 3hjoA-2hufA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		4 / 8 GLU A  84
TYR A 201
PHE A 149
ILE A  97
 None
 1.00A 3jz0B-2hufA:
undetectable		 3jz0B-2hufA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		4 / 8 ASN A  89
LEU A 176
ALA A 199
SER A 220
 None
 0.97A 3kp6A-2hufA:
undetectable		 3kp6A-2hufA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		5 / 11 THR A 350
GLN A 129
GLY A 103
THR A 102
ASP A 312
 None
 1.35A 3mg0H-2hufA:
undetectable
3mg0I-2hufA:
undetectable		 3mg0H-2hufA:
21.61
3mg0I-2hufA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		5 / 9 ASP A 107
GLY A 106
VAL A 182
THR A 151
GLY A 153
 None
None
LLP  A 206 ( 4.1A)
LLP  A 206 ( 4.6A)
None
 1.41A 4acaB-2hufA:
2.7
4acaC-2hufA:
2.9		 4acaB-2hufA:
22.16
4acaC-2hufA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_B_ACTB502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		4 / 5 GLU A 367
ARG A 294
THR A 366
ASP A 370
 None
 1.43A 4e7cA-2hufA:
0.0
4e7cB-2hufA:
0.0		 4e7cA-2hufA:
24.25
4e7cB-2hufA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		5 / 12 GLY A 162
LEU A 150
GLN A 161
GLU A 196
LEU A 169
 None
 1.12A 4fr0A-2hufA:
undetectable		 4fr0A-2hufA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		4 / 8 GLN A 362
GLY A 361
THR A 365
ARG A 368
 None
LLP  A 206 ( 4.8A)
None
None
 0.97A 4k87A-2hufA:
undetectable		 4k87A-2hufA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		5 / 12 ASP A 240
VAL A 224
TYR A 227
PHE A  73
PHE A 251
 None
 1.28A 4mm4A-2hufA:
undetectable		 4mm4A-2hufA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		4 / 5 PHE A  73
PRO A 216
VAL A 217
PHE A  65
 None
 1.04A 4w5oA-2hufA:
undetectable		 4w5oA-2hufA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		4 / 5 PHE A  73
PRO A 216
VAL A 217
PHE A  65
 None
 1.02A 4z4cA-2hufA:
undetectable		 4z4cA-2hufA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		4 / 5 PHE A  73
PRO A 216
VAL A 217
PHE A  65
 None
 1.04A 4z4dA-2hufA:
1.8		 4z4dA-2hufA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		4 / 5 PHE A  73
PRO A 216
VAL A 217
PHE A  65
 None
 1.02A 4z4eA-2hufA:
undetectable		 4z4eA-2hufA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		4 / 8 ILE A 178
LEU A 176
LEU A  91
ARG A 226
 None
 0.73A 4zvcA-2hufA:
undetectable
4zvcB-2hufA:
0.0		 4zvcA-2hufA:
16.03
4zvcB-2hufA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		4 / 8 LEU A  91
ARG A 226
ILE A 178
LEU A 176
 None
 0.74A 4zvcA-2hufA:
undetectable
4zvcB-2hufA:
0.0		 4zvcA-2hufA:
16.03
4zvcB-2hufA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		4 / 7 ASP A 180
TRP A 105
THR A 151
SER A 184
 LLP  A 206 ( 2.9A)
LLP  A 206 ( 3.5A)
LLP  A 206 ( 4.6A)
None
 1.13A 5b6iA-2hufA:
undetectable		 5b6iA-2hufA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		4 / 6 ASP A 180
TRP A 105
THR A 151
SER A 184
 LLP  A 206 ( 2.9A)
LLP  A 206 ( 3.5A)
LLP  A 206 ( 4.6A)
None
 1.12A 5b6iB-2hufA:
undetectable		 5b6iB-2hufA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		3 / 3 MET A 190
GLN A  66
ARG A 194
 None
 0.96A 5ewzB-2hufA:
undetectable		 5ewzB-2hufA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		3 / 3 MET A 190
GLN A  66
ARG A 194
 None
 0.95A 5m35B-2hufA:
undetectable		 5m35B-2hufA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		3 / 3 MET A 190
GLN A  66
ARG A 194
 None
 0.89A 5m36A-2hufA:
undetectable		 5m36A-2hufA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		4 / 6 PHE A  73
PRO A 216
VAL A 217
PHE A  65
 None
 1.02A 5t7bA-2hufA:
undetectable		 5t7bA-2hufA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		5 / 9 ILE A 343
LEU A 299
PHE A 355
TYR A 296
ALA A 292
 None
 1.33A 5x66C-2hufA:
undetectable		 5x66C-2hufA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		4 / 6 ARG A 356
GLY A  24
SER A 155
THR A 316
 1BO  A 602 (-3.0A)
None
LLP  A 206 (-2.8A)
None
 1.13A 5ysiA-2hufA:
undetectable		 5ysiA-2hufA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		5 / 12 TYR A  63
ALA A 272
LEU A 284
ILE A 285
LEU A 185
 None
 1.12A 6aybA-2hufA:
undetectable		 6aybA-2hufA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		3 / 3 MET A 190
GLN A  66
ARG A 194
 None
 0.94A 6fn9A-2hufA:
undetectable		 6fn9A-2hufA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		3 / 3 MET A 190
GLN A  66
ARG A 194
 None
 0.98A 6fnaB-2hufA:
undetectable		 6fnaB-2hufA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		3 / 3 MET A 190
GLN A  66
ARG A 194
 None
 0.92A 6fnbA-2hufA:
undetectable		 6fnbA-2hufA:
19.08