SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2huh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SVL_A_ACTA411_0 (P2X PURINOCEPTOR 3)	2huh	PUTATIVE DNA MISMATCH REPAIR PROTEIN (Bacteroides thetaiotaomicron)	4 / 5	LYS A 172 VAL A 85 ASP A 89 ASN A 145	None	1.41A	5svlA-2huhA: 0.0	5svlA-2huhA: 17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TE8_B_08JB602_1 (CYTOCHROME P450 3A4)	2huh	PUTATIVE DNA MISMATCH REPAIR PROTEIN (Bacteroides thetaiotaomicron)	4 / 8	SER A 118 ALA A 170 ILE A 179 ALA A 178	None	0.83A	5te8B-2huhA: undetectable	5te8B-2huhA: 15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VOO_A_C2FA3001_1 (5-METHYLTETRAHYDROFO LATE HOMOCYSTEINE S-METHYLTRANSFERASE)	2huh	PUTATIVE DNA MISMATCH REPAIR PROTEIN (Bacteroides thetaiotaomicron)	4 / 5	ASN A 145 ASP A 117 ASN A 92 ASP A 219	None	1.12A	5vooA-2huhA: undetectable	5vooA-2huhA: 23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VOO_C_C2FC702_1 (5-METHYLTETRAHYDROFO LATE HOMOCYSTEINE S-METHYLTRANSFERASE)	2huh	PUTATIVE DNA MISMATCH REPAIR PROTEIN (Bacteroides thetaiotaomicron)	4 / 5	ASN A 145 ASP A 117 ASN A 92 ASP A 219	None	1.11A	5vooC-2huhA: undetectable	5vooC-2huhA: 23.77

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["5SVL_A_ACTA411_0","P2X PURINOCEPTOR 3","2huh","PUTATIVE DNA MISMATCH REPAIR PROTEIN","Bacteroides thetaiotaomicron",4,"LYS A 172;VAL A  85;ASP A  89;ASN A 145","None","1.41A","5svlA-2huhA:0.0","5svlA-2huhA:17.60"],["5TE8_B_08JB602_1","CYTOCHROME P450 3A4","2huh","PUTATIVE DNA MISMATCH REPAIR PROTEIN","Bacteroides thetaiotaomicron",4,"SER A 118;ALA A 170;ILE A 179;ALA A 178","None","0.83A","5te8B-2huhA:undetectable","5te8B-2huhA:15.22"],["5VOO_A_C2FA3001_1","5-METHYLTETRAHYDROFOLATE HOMOCYSTEINE S-METHYLTRANSFERASE","2huh","PUTATIVE DNA MISMATCH REPAIR PROTEIN","Bacteroides thetaiotaomicron",4,"ASN A 145;ASP A 117;ASN A  92;ASP A 219","None","1.12A","5vooA-2huhA:undetectable","5vooA-2huhA:23.77"],["5VOO_C_C2FC702_1","5-METHYLTETRAHYDROFOLATE HOMOCYSTEINE S-METHYLTRANSFERASE","2huh","PUTATIVE DNA MISMATCH REPAIR PROTEIN","Bacteroides thetaiotaomicron",4,"ASN A 145;ASP A 117;ASN A  92;ASP A 219","None","1.11A","5vooC-2huhA:undetectable","5vooC-2huhA:23.77"]]