SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hun'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 242
LEU A 229
ALA A 226
LEU A  82
PHE A  19
 None
None
None
NAD  A 801 (-4.3A)
None
 1.18A 1og5B-2hunA:
undetectable		 1og5B-2hunA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A 258
GLU A 265
THR A 210
ILE A 205
 None
 1.12A 1qvtA-2hunA:
undetectable		 1qvtA-2hunA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE
(Pyrococcus
horikoshii) 		3 / 3 TRP A 294
LEU A 292
LYS A 233
 None
 1.46A 1yajK-2hunA:
3.1		 1yajK-2hunA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE
(Pyrococcus
horikoshii) 		5 / 7 LEU A 231
GLY A  16
ILE A  20
VAL A 123
ILE A 227
 None
 1.43A 2aojB-2hunA:
undetectable		 2aojB-2hunA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE
(Pyrococcus
horikoshii) 		4 / 8 VAL A 123
LEU A 292
LYS A 233
GLY A 234
 None
 1.01A 3af0A-2hunA:
undetectable		 3af0A-2hunA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE
(Pyrococcus
horikoshii) 		3 / 3 PRO A 118
LEU A 171
ARG A 237
 None
 0.89A 3aqiA-2hunA:
2.9		 3aqiA-2hunA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE
(Pyrococcus
horikoshii) 		4 / 5 VAL A 253
VAL A 254
THR A 307
THR A 249
 None
 1.27A 3bjwG-2hunA:
undetectable		 3bjwG-2hunA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 191
PRO A 193
TYR A 311
THR A 307
ILE A 304
 None
 1.24A 3g4lC-2hunA:
undetectable		 3g4lC-2hunA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE
(Pyrococcus
horikoshii) 		5 / 12 ARG A 144
LEU A 283
ILE A 134
GLY A 132
LEU A 145
 None
 1.17A 3n8xA-2hunA:
undetectable		 3n8xA-2hunA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A  33
ILE A  35
VAL A  69
LEU A  72
 None
 0.70A 3r9vA-2hunA:
undetectable
3r9vB-2hunA:
undetectable		 3r9vA-2hunA:
22.32
3r9vB-2hunA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE
(Pyrococcus
horikoshii) 		5 / 11 SER A  17
ILE A  20
VAL A   8
VAL A  32
ILE A  35
 None
 1.39A 3rf4A-2hunA:
undetectable
3rf4C-2hunA:
undetectable		 3rf4A-2hunA:
15.48
3rf4C-2hunA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE
(Pyrococcus
horikoshii) 		5 / 11 ILE A  35
SER A  17
ILE A  20
VAL A   8
VAL A  32
 None
 1.37A 3rf4A-2hunA:
undetectable
3rf4B-2hunA:
undetectable		 3rf4A-2hunA:
15.48
3rf4B-2hunA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE
(Pyrococcus
horikoshii) 		5 / 11 ILE A  35
SER A  17
ILE A  20
VAL A   8
VAL A  32
 None
 1.36A 3rf4B-2hunA:
undetectable
3rf4C-2hunA:
undetectable		 3rf4B-2hunA:
15.48
3rf4C-2hunA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE
(Pyrococcus
horikoshii) 		6 / 12 LEU A 110
ASP A  62
ASP A  65
VAL A  69
ILE A  35
GLY A  10
 None
NAD  A 801 (-3.2A)
None
None
None
NAD  A 801 (-3.2A)
 1.36A 3so9B-2hunA:
undetectable		 3so9B-2hunA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE
(Pyrococcus
horikoshii) 		5 / 12 VAL A  63
HIS A  81
LEU A  82
ALA A  83
THR A 127
 NAD  A 801 (-3.7A)
None
NAD  A 801 (-4.3A)
NAD  A 801 (-3.5A)
NAD  A 801 (-4.2A)
 1.12A 5nd3B-2hunA:
5.4		 5nd3B-2hunA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE
(Pyrococcus
horikoshii) 		5 / 12 HIS A 100
LEU A   7
VAL A  73
THR A 106
GLY A 105
 None
 1.01A 6brdA-2hunA:
4.0		 6brdA-2hunA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE
(Pyrococcus
horikoshii) 		5 / 12 LYS A 194
THR A 210
ALA A 199
LEU A 270
LEU A 258
 None
 1.09A 6ie8A-2hunA:
undetectable		 6ie8A-2hunA:
21.52