SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2huo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		4 / 5 HIS A 123
HIS A 194
HIS A 220
ASP A 253
 FE  A 301 ( 3.2A)
FE  A 302 ( 3.2A)
FE  A 302 (-3.2A)
FE  A 301 ( 2.5A)
 0.97A 1e9yB-2huoA:
undetectable		 1e9yB-2huoA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		4 / 5 THR A 102
ASP A 253
HIS A 220
HIS A  98
 None
FE  A 301 ( 2.5A)
FE  A 302 (-3.2A)
FE  A 301 (-3.2A)
 1.25A 1ei6A-2huoA:
undetectable		 1ei6A-2huoA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		4 / 8 ASP A 124
HIS A 123
HIS A 220
HIS A  98
 FE  A 302 ( 2.5A)
FE  A 301 ( 3.2A)
FE  A 302 (-3.2A)
FE  A 301 (-3.2A)
 0.71A 1ei6D-2huoA:
undetectable		 1ei6D-2huoA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_2
(ANDROGEN RECEPTOR)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		4 / 5 HIS A  98
MET A  74
ARG A 268
VAL A  91
 FE  A 301 (-3.2A)
None
None
None
 1.46A 1gs4A-2huoA:
0.0		 1gs4A-2huoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YDB_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		5 / 11 HIS A  98
HIS A 123
PHE A 252
THR A 102
THR A 256
 FE  A 301 (-3.2A)
FE  A 301 ( 3.2A)
None
None
None
 1.49A 1ydbA-2huoA:
undetectable		 1ydbA-2huoA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		4 / 7 LYS A 127
HIS A 220
SER A 221
ASP A 124
 INS  A 303 (-2.6A)
FE  A 302 (-3.2A)
INS  A 303 (-2.8A)
FE  A 302 ( 2.5A)
 1.41A 2rk8B-2huoA:
undetectable		 2rk8B-2huoA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		5 / 12 ASP A  88
PHE A 156
TYR A  31
ASP A 142
HIS A  48
 INS  A 303 (-3.7A)
None
None
INS  A 303 (-3.5A)
None
 1.43A 2x2iA-2huoA:
undetectable		 2x2iA-2huoA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		5 / 12 ILE A 217
GLY A 120
LEU A 125
PHE A  97
ASP A 124
 None
None
None
None
FE  A 302 ( 2.5A)
 1.21A 2yvlC-2huoA:
undetectable		 2yvlC-2huoA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		5 / 12 ASP A  88
LYS A 127
ASP A 124
LEU A 254
HIS A 123
 INS  A 303 (-3.7A)
INS  A 303 (-2.6A)
FE  A 302 ( 2.5A)
None
FE  A 301 ( 3.2A)
 1.47A 2zj0B-2huoA:
undetectable		 2zj0B-2huoA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		5 / 12 ASP A  88
LYS A 127
ASP A 124
LEU A 254
HIS A 123
 INS  A 303 (-3.7A)
INS  A 303 (-2.6A)
FE  A 302 ( 2.5A)
None
FE  A 301 ( 3.2A)
 1.45A 3ce6B-2huoA:
undetectable		 3ce6B-2huoA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		5 / 12 ASP A  88
LYS A 127
ASP A 124
LEU A 254
HIS A 123
 INS  A 303 (-3.7A)
INS  A 303 (-2.6A)
FE  A 302 ( 2.5A)
None
FE  A 301 ( 3.2A)
 1.42A 3glqA-2huoA:
undetectable		 3glqA-2huoA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		5 / 12 ASP A  88
LYS A 127
ASP A 124
LEU A 254
HIS A 123
 INS  A 303 (-3.7A)
INS  A 303 (-2.6A)
FE  A 302 ( 2.5A)
None
FE  A 301 ( 3.2A)
 1.43A 3glqB-2huoA:
undetectable		 3glqB-2huoA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		5 / 12 ASP A  88
LYS A 127
ASP A 124
LEU A 254
HIS A 123
 INS  A 303 (-3.7A)
INS  A 303 (-2.6A)
FE  A 302 ( 2.5A)
None
FE  A 301 ( 3.2A)
 1.41A 3n58C-2huoA:
undetectable		 3n58C-2huoA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		5 / 12 ASP A  88
LYS A 127
ASP A 124
LEU A 254
HIS A 123
 INS  A 303 (-3.7A)
INS  A 303 (-2.6A)
FE  A 302 ( 2.5A)
None
FE  A 301 ( 3.2A)
 1.41A 3n58D-2huoA:
undetectable		 3n58D-2huoA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		4 / 6 GLN A 151
PHE A 222
PRO A 145
LEU A 185
 None
 1.26A 3tgvB-2huoA:
undetectable		 3tgvB-2huoA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		4 / 6 GLN A 151
PHE A 222
PRO A 145
LEU A 185
 None
 1.24A 3tgvD-2huoA:
undetectable		 3tgvD-2huoA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		3 / 3 ARG A  60
ASP A 239
GLN A 238
 None
 0.93A 4azsA-2huoA:
undetectable		 4azsA-2huoA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		4 / 8 LEU A 267
VAL A 264
ALA A 103
LEU A 121
 None
 0.82A 4qrcA-2huoA:
undetectable		 4qrcA-2huoA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		5 / 6 HIS A 123
HIS A  98
HIS A 194
HIS A 220
ASP A 253
 FE  A 301 ( 3.2A)
FE  A 301 (-3.2A)
FE  A 302 ( 3.2A)
FE  A 302 (-3.2A)
FE  A 301 ( 2.5A)
 0.99A 4ubpC-2huoA:
undetectable		 4ubpC-2huoA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		4 / 6 PHE A 207
PRO A 280
THR A  72
ILE A 275
 None
 1.41A 5ih0A-2huoA:
undetectable		 5ih0A-2huoA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		3 / 3 THR A 143
SER A 221
ASP A  85
 None
INS  A 303 (-2.8A)
INS  A 303 (-2.7A)
 0.84A 5kvaA-2huoA:
undetectable		 5kvaA-2huoA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		3 / 3 THR A 143
SER A 221
ASP A  85
 None
INS  A 303 (-2.8A)
INS  A 303 (-2.7A)
 0.84A 5kvaB-2huoA:
undetectable		 5kvaB-2huoA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		4 / 8 ASP A 142
PRO A 224
TYR A 231
SER A 159
 INS  A 303 (-3.5A)
None
None
None
 1.09A 5l1fA-2huoA:
undetectable
5l1fB-2huoA:
undetectable		 5l1fA-2huoA:
16.53
5l1fB-2huoA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		5 / 12 ASP A  88
LYS A 127
ASP A 124
LEU A 254
HIS A 123
 INS  A 303 (-3.7A)
INS  A 303 (-2.6A)
FE  A 302 ( 2.5A)
None
FE  A 301 ( 3.2A)
 1.46A 6aphA-2huoA:
undetectable		 6aphA-2huoA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_1
(-)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		5 / 12 ASP A  88
LYS A 127
ASP A 124
LEU A 254
HIS A 123
 INS  A 303 (-3.7A)
INS  A 303 (-2.6A)
FE  A 302 ( 2.5A)
None
FE  A 301 ( 3.2A)
 1.40A 6f3mC-2huoA:
undetectable		 6f3mC-2huoA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		5 / 12 ASP A  88
LYS A 127
ASP A 124
LEU A 254
HIS A 123
 INS  A 303 (-3.7A)
INS  A 303 (-2.6A)
FE  A 302 ( 2.5A)
None
FE  A 301 ( 3.2A)
 1.44A 6gbnB-2huoA:
undetectable		 6gbnB-2huoA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_1
(-)		 2huo INOSITOL OXYGENASE
(Mus
musculus) 		5 / 12 ASP A  88
LYS A 127
ASP A 124
LEU A 254
HIS A 123
 INS  A 303 (-3.7A)
INS  A 303 (-2.6A)
FE  A 302 ( 2.5A)
None
FE  A 301 ( 3.2A)
 1.43A 6gbnC-2huoA:
undetectable		 6gbnC-2huoA:
19.82