SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hur'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 2hur NUCLEOSIDE
DIPHOSPHATE KINASE
(Escherichia
coli) 		4 / 6 MET A  67
VAL A  64
LEU A  63
PHE A  59
 None
 0.96A 1x8vA-2hurA:
undetectable		 1x8vA-2hurA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2hur NUCLEOSIDE
DIPHOSPHATE KINASE
(Escherichia
coli) 		3 / 3 LEU A  63
TYR A  51
GLY A  49
 None
 0.64A 2ocuA-2hurA:
undetectable		 2ocuA-2hurA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2hur NUCLEOSIDE
DIPHOSPHATE KINASE
(Escherichia
coli) 		5 / 12 GLY A  49
ALA A  47
THR A  68
ILE A  72
ILE A  10
 None
 1.25A 3ld6A-2hurA:
undetectable		 3ld6A-2hurA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2hur NUCLEOSIDE
DIPHOSPHATE KINASE
(Escherichia
coli) 		4 / 7 TYR A  51
ASN A 114
GLU A 113
PRO A  95
 None
SO4  A 200 (-3.3A)
None
None
 1.09A 3ugrA-2hurA:
undetectable		 3ugrA-2hurA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 2hur NUCLEOSIDE
DIPHOSPHATE KINASE
(Escherichia
coli) 		4 / 6 HIS A 117
GLU A 128
ASP A 120
SER A 124
 SO4  A 200 (-3.8A)
None
None
None
 1.09A 4apjA-2hurA:
undetectable
4apjP-2hurA:
undetectable		 4apjA-2hurA:
13.23
4apjP-2hurA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 2hur NUCLEOSIDE
DIPHOSPHATE KINASE
(Escherichia
coli) 		4 / 4 ILE A 129
VAL A  74
VAL A  76
ARG A   5
 None
 1.34A 4m6tA-2hurA:
undetectable		 4m6tA-2hurA:
24.06