SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hv2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 2hv2 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		5 / 11 TYR A 213
ILE A 202
LEU A 187
VAL A 180
ASP A 395
 None
 1.49A 1mrlA-2hv2A:
undetectable
1mrlB-2hv2A:
undetectable		 1mrlA-2hv2A:
19.35
1mrlB-2hv2A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2hv2 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		5 / 12 ILE A 285
LEU A 386
PHE A 357
ILE A 323
LEU A 307
 None
 1.22A 1rh3A-2hv2A:
undetectable		 1rh3A-2hv2A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 2hv2 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		4 / 7 PHE A  64
ILE A  78
THR A  44
THR A  62
 None
 0.96A 1sbrB-2hv2A:
undetectable		 1sbrB-2hv2A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 2hv2 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		5 / 11 LEU A 356
ALA A 379
LEU A 366
ALA A 348
THR A 352
 None
 1.22A 1tz8A-2hv2A:
undetectable
1tz8B-2hv2A:
undetectable		 1tz8A-2hv2A:
16.62
1tz8B-2hv2A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 2hv2 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 TRP A 185
LEU A 187
LYS A 166
 None
 1.36A 1yajK-2hv2A:
undetectable		 1yajK-2hv2A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2hv2 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		5 / 12 VAL A 214
THR A 222
ILE A 243
PHE A 223
HIS A 254
 None
 1.41A 4c49C-2hv2A:
undetectable		 4c49C-2hv2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2hv2 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		5 / 12 VAL A 214
THR A 222
ILE A 243
PHE A 223
HIS A 254
 None
 1.38A 4c49D-2hv2A:
undetectable		 4c49D-2hv2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2hv2 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		4 / 8 SER A 206
LEU A 231
ALA A 210
SER A 205
 None
 0.97A 4ikjA-2hv2A:
undetectable
4ikjB-2hv2A:
undetectable		 4ikjA-2hv2A:
16.62
4ikjB-2hv2A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2hv2 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		5 / 12 PHE A  68
TYR A 295
LEU A 288
ILE A 285
LEU A 358
 None
 1.30A 4k39A-2hv2A:
undetectable		 4k39A-2hv2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 2hv2 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		5 / 12 ILE A 323
ASP A 375
ILE A 378
LEU A 372
LEU A 356
 None
 1.09A 4m2xE-2hv2A:
undetectable		 4m2xE-2hv2A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 2hv2 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 PRO A 391
MET A 390
TYR A 360
 None
 0.98A 4qa0B-2hv2A:
undetectable		 4qa0B-2hv2A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 2hv2 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 PRO A 391
MET A 390
TYR A 360
 None
 0.97A 4qa0A-2hv2A:
undetectable		 4qa0A-2hv2A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 2hv2 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 PRO A 391
MET A 390
TYR A 360
 None
 0.97A 4qa2B-2hv2A:
undetectable		 4qa2B-2hv2A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 2hv2 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		4 / 8 PHE A 297
LEU A 386
LEU A 292
PHE A 291
 None
 0.91A 4qopC-2hv2A:
undetectable		 4qopC-2hv2A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hv2 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		5 / 8 LEU A 358
GLY A 359
ALA A 283
LEU A 111
GLY A 178
 None
 1.17A 4zauA-2hv2A:
undetectable		 4zauA-2hv2A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 2hv2 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		4 / 8 TYR A 169
ASP A 395
GLU A 227
ILE A 215
 None
 1.01A 5cfsA-2hv2A:
undetectable		 5cfsA-2hv2A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 2hv2 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		5 / 12 GLU A 394
LEU A 264
TYR A 136
GLY A 258
ALA A 260
 None
PG4  A 801 ( 4.5A)
PG4  A 801 (-4.8A)
None
None
 1.18A 5e3iA-2hv2A:
undetectable		 5e3iA-2hv2A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2hv2 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 LYS A   4
LEU A  55
ILE A  96
 None
 0.80A 5kc4A-2hv2A:
undetectable		 5kc4A-2hv2A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2hv2 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 SER A 205
TYR A 204
TYR A 203
 None
 0.66A 5lakA-2hv2A:
undetectable
5lakI-2hv2A:
undetectable		 5lakA-2hv2A:
18.45
5lakI-2hv2A:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2hv2 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 SER A 205
TYR A 204
TYR A 203
 None
 0.60A 5lakC-2hv2A:
undetectable
5lakJ-2hv2A:
undetectable		 5lakC-2hv2A:
18.45
5lakJ-2hv2A:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2hv2 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		5 / 11 ILE A 325
LEU A 386
PHE A 297
LEU A 292
ILE A 323
 None
 1.05A 5z6mA-2hv2A:
undetectable		 5z6mA-2hv2A:
17.53