SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hvb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A  23
HIS A  50
HIS A  25
 FE  A 201 (-3.7A)
FE  A 201 (-3.5A)
FE  A 201 (-3.3A)
 0.56A 1oe2A-2hvbA:
undetectable		 1oe2A-2hvbA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  25
HIS A 114
HIS A  56
HIS A  50
 FE  A 201 (-3.3A)
FE  A 201 (-3.2A)
FE  A 201 (-3.4A)
FE  A 201 (-3.5A)
 1.37A 2fqeA-2hvbA:
undetectable		 2fqeA-2hvbA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
HIS A 114
HIS A  25
HIS A  50
 FE  A 201 (-3.4A)
FE  A 201 (-3.2A)
FE  A 201 (-3.3A)
FE  A 201 (-3.5A)
 1.29A 2fqeA-2hvbA:
undetectable		 2fqeA-2hvbA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 5 LEU A 123
GLY A 103
PHE A  65
ARG A  33
 None
 0.88A 3smtA-2hvbA:
undetectable		 3smtA-2hvbA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  84
GLU A  23
HIS A 114
LEU A 116
 None
FE  A 201 (-3.7A)
FE  A 201 (-3.2A)
None
 1.42A 4m2rA-2hvbA:
undetectable		 4m2rA-2hvbA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA504_0
(LACCASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
CYH A 111
ILE A 113
HIS A 114
 FE  A 201 (-3.4A)
FE  A 201 (-2.2A)
None
FE  A 201 (-3.2A)
 1.19A 5mejA-2hvbA:
undetectable		 5mejA-2hvbA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA504_0
(LACCASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
CYH A 111
ILE A 113
HIS A 114
 FE  A 201 (-3.4A)
FE  A 201 (-2.2A)
None
FE  A 201 (-3.2A)
 1.21A 5mewA-2hvbA:
undetectable		 5mewA-2hvbA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA504_0
(LACCASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
CYH A 111
ILE A 113
HIS A 114
 FE  A 201 (-3.4A)
FE  A 201 (-2.2A)
None
FE  A 201 (-3.2A)
 1.22A 5mhuA-2hvbA:
undetectable		 5mhuA-2hvbA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA504_0
(LACCASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
CYH A 111
ILE A 113
HIS A 114
 FE  A 201 (-3.4A)
FE  A 201 (-2.2A)
None
FE  A 201 (-3.2A)
 1.23A 5mhvA-2hvbA:
undetectable		 5mhvA-2hvbA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA604_0
(LACCASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
CYH A 111
ILE A 113
HIS A 114
 FE  A 201 (-3.4A)
FE  A 201 (-2.2A)
None
FE  A 201 (-3.2A)
 1.23A 5mhwA-2hvbA:
undetectable		 5mhwA-2hvbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA604_0
(LACCASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
CYH A 111
ILE A 113
HIS A 114
 FE  A 201 (-3.4A)
FE  A 201 (-2.2A)
None
FE  A 201 (-3.2A)
 1.22A 5mhxA-2hvbA:
undetectable		 5mhxA-2hvbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA604_0
(LACCASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
CYH A 111
ILE A 113
HIS A 114
 FE  A 201 (-3.4A)
FE  A 201 (-2.2A)
None
FE  A 201 (-3.2A)
 1.23A 5mhyA-2hvbA:
undetectable		 5mhyA-2hvbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA604_0
(LACCASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
CYH A 111
ILE A 113
HIS A 114
 FE  A 201 (-3.4A)
FE  A 201 (-2.2A)
None
FE  A 201 (-3.2A)
 1.23A 5mhzA-2hvbA:
undetectable		 5mhzA-2hvbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA604_0
(LACCASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
CYH A 111
ILE A 113
HIS A 114
 FE  A 201 (-3.4A)
FE  A 201 (-2.2A)
None
FE  A 201 (-3.2A)
 1.23A 5mi1A-2hvbA:
undetectable		 5mi1A-2hvbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA603_0
(LACCASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
HIS A 114
HIS A  25
HIS A  50
 FE  A 201 (-3.4A)
FE  A 201 (-3.2A)
FE  A 201 (-3.3A)
FE  A 201 (-3.5A)
 1.23A 5mi2A-2hvbA:
undetectable		 5mi2A-2hvbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA604_0
(LACCASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
CYH A 111
ILE A 113
HIS A 114
 FE  A 201 (-3.4A)
FE  A 201 (-2.2A)
None
FE  A 201 (-3.2A)
 1.23A 5mi2A-2hvbA:
undetectable		 5mi2A-2hvbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA603_0
(LACCASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
HIS A 114
HIS A  25
HIS A  50
 FE  A 201 (-3.4A)
FE  A 201 (-3.2A)
FE  A 201 (-3.3A)
FE  A 201 (-3.5A)
 1.23A 5miaA-2hvbA:
undetectable		 5miaA-2hvbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA604_0
(LACCASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
CYH A 111
ILE A 113
HIS A 114
 FE  A 201 (-3.4A)
FE  A 201 (-2.2A)
None
FE  A 201 (-3.2A)
 1.23A 5miaA-2hvbA:
undetectable		 5miaA-2hvbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA603_0
(LACCASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
HIS A 114
HIS A  25
HIS A  50
 FE  A 201 (-3.4A)
FE  A 201 (-3.2A)
FE  A 201 (-3.3A)
FE  A 201 (-3.5A)
 1.23A 5mibA-2hvbA:
undetectable		 5mibA-2hvbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA604_0
(LACCASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
CYH A 111
ILE A 113
HIS A 114
 FE  A 201 (-3.4A)
FE  A 201 (-2.2A)
None
FE  A 201 (-3.2A)
 1.23A 5mibA-2hvbA:
undetectable		 5mibA-2hvbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA603_0
(LACCASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
HIS A 114
HIS A  25
HIS A  50
 FE  A 201 (-3.4A)
FE  A 201 (-3.2A)
FE  A 201 (-3.3A)
FE  A 201 (-3.5A)
 1.22A 5micA-2hvbA:
undetectable		 5micA-2hvbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA604_0
(LACCASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
CYH A 111
ILE A 113
HIS A 114
 FE  A 201 (-3.4A)
FE  A 201 (-2.2A)
None
FE  A 201 (-3.2A)
 1.23A 5micA-2hvbA:
undetectable		 5micA-2hvbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA603_0
(LACCASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
HIS A 114
HIS A  25
HIS A  50
 FE  A 201 (-3.4A)
FE  A 201 (-3.2A)
FE  A 201 (-3.3A)
FE  A 201 (-3.5A)
 1.22A 5midA-2hvbA:
undetectable		 5midA-2hvbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA604_0
(LACCASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
CYH A 111
ILE A 113
HIS A 114
 FE  A 201 (-3.4A)
FE  A 201 (-2.2A)
None
FE  A 201 (-3.2A)
 1.24A 5midA-2hvbA:
undetectable		 5midA-2hvbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA603_0
(LACCASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
HIS A 114
HIS A  25
HIS A  50
 FE  A 201 (-3.4A)
FE  A 201 (-3.2A)
FE  A 201 (-3.3A)
FE  A 201 (-3.5A)
 1.23A 5mieA-2hvbA:
undetectable		 5mieA-2hvbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA604_0
(LACCASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
CYH A 111
ILE A 113
HIS A 114
 FE  A 201 (-3.4A)
FE  A 201 (-2.2A)
None
FE  A 201 (-3.2A)
 1.23A 5mieA-2hvbA:
undetectable		 5mieA-2hvbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA603_0
(LACCASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
HIS A 114
HIS A  25
HIS A  50
 FE  A 201 (-3.4A)
FE  A 201 (-3.2A)
FE  A 201 (-3.3A)
FE  A 201 (-3.5A)
 1.22A 5migA-2hvbA:
undetectable		 5migA-2hvbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA604_0
(LACCASE 2)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
CYH A 111
ILE A 113
HIS A 114
 FE  A 201 (-3.4A)
FE  A 201 (-2.2A)
None
FE  A 201 (-3.2A)
 1.24A 5migA-2hvbA:
undetectable		 5migA-2hvbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA606_0
(TYROSINASE)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  25
CYH A 111
HIS A  56
HIS A  50
 FE  A 201 (-3.3A)
FE  A 201 (-2.2A)
FE  A 201 (-3.4A)
FE  A 201 (-3.5A)
 1.18A 5zrdA-2hvbA:
undetectable		 5zrdA-2hvbA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA606_0
(TYROSINASE)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A  56
CYH A 111
HIS A  25
HIS A 114
 FE  A 201 (-3.4A)
FE  A 201 (-2.2A)
FE  A 201 (-3.3A)
FE  A 201 (-3.2A)
 1.43A 5zrdA-2hvbA:
undetectable		 5zrdA-2hvbA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA606_0
(TYROSINASE)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A 114
CYH A 111
HIS A  56
HIS A  25
 FE  A 201 (-3.2A)
FE  A 201 (-2.2A)
FE  A 201 (-3.4A)
FE  A 201 (-3.3A)
 1.42A 5zrdA-2hvbA:
undetectable		 5zrdA-2hvbA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA606_0
(TYROSINASE)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A 114
CYH A 111
HIS A  56
HIS A  50
 FE  A 201 (-3.2A)
FE  A 201 (-2.2A)
FE  A 201 (-3.4A)
FE  A 201 (-3.5A)
 1.26A 5zrdA-2hvbA:
undetectable		 5zrdA-2hvbA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 5 HIS A  25
CYH A 111
HIS A  56
HIS A  50
 FE  A 201 (-3.3A)
FE  A 201 (-2.2A)
FE  A 201 (-3.4A)
FE  A 201 (-3.5A)
 1.18A 5zrdB-2hvbA:
3.1		 5zrdB-2hvbA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 5 HIS A 114
CYH A 111
HIS A  56
HIS A  50
 FE  A 201 (-3.2A)
FE  A 201 (-2.2A)
FE  A 201 (-3.4A)
FE  A 201 (-3.5A)
 1.19A 5zrdB-2hvbA:
3.1		 5zrdB-2hvbA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 5 HIS A  25
CYH A 111
HIS A  56
HIS A  50
 FE  A 201 (-3.3A)
FE  A 201 (-2.2A)
FE  A 201 (-3.4A)
FE  A 201 (-3.5A)
 1.22A 5zrdC-2hvbA:
3.8		 5zrdC-2hvbA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 5 HIS A 114
CYH A 111
HIS A  56
HIS A  50
 FE  A 201 (-3.2A)
FE  A 201 (-2.2A)
FE  A 201 (-3.4A)
FE  A 201 (-3.5A)
 1.28A 5zrdC-2hvbA:
3.8		 5zrdC-2hvbA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 5 HIS A  25
CYH A 111
HIS A  56
HIS A  50
 FE  A 201 (-3.3A)
FE  A 201 (-2.2A)
FE  A 201 (-3.4A)
FE  A 201 (-3.5A)
 1.15A 5zrdD-2hvbA:
3.7		 5zrdD-2hvbA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 2hvb SUPEROXIDE REDUCTASE
(Pyrococcus
horikoshii) 		4 / 5 HIS A 114
CYH A 111
HIS A  56
HIS A  50
 FE  A 201 (-3.2A)
FE  A 201 (-2.2A)
FE  A 201 (-3.4A)
FE  A 201 (-3.5A)
 1.19A 5zrdD-2hvbA:
3.7		 5zrdD-2hvbA:
13.26