SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hw6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1MUO_A_ADNA1_1 (AURORA-RELATED KINASE 1)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	6 / 9	LEU A 55 GLY A 56 VAL A 63 ALA A 76 LEU A 108 LEU A 177	None	0.78A	1muoA-2hw6A: 24.3	1muoA-2hw6A: 30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q97_B_ADNB486_1 (SR PROTEIN KINASE)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	4 / 4	VAL A 63 ALA A 76 LEU A 108 PHE A 124	None	0.45A	1q97B-2hw6A: 21.4	1q97B-2hw6A: 26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S8F_A_BEZA1501_0 (RAS-RELATED PROTEIN RAB-9A)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	4 / 5	ILE A 310 TRP A 299 LEU A 314 PRO A 259	None	1.20A	1s8fA-2hw6A: undetectable 1s8fB-2hw6A: undetectable	1s8fA-2hw6A: 20.90 1s8fB-2hw6A: 20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UWH_B_BAXB1723_2 (B-RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	4 / 6	VAL A 333 ILE A 107 ILE A 166 ASP A 159	None	0.86A	1uwhB-2hw6A: 22.4	1uwhB-2hw6A: 26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UWJ_A_BAXA1723_2 (B-RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	4 / 7	LYS A 78 LEU A 98 ILE A 107 ILE A 166	None	0.74A	1uwjA-2hw6A: 22.3	1uwjA-2hw6A: 26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XBB_A_STIA1_1 (TYROSINE-PROTEIN KINASE SYK)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	5 / 9	LEU A 55 VAL A 63 ALA A 76 GLY A 130 LEU A 177	None	0.54A	1xbbA-2hw6A: 22.0	1xbbA-2hw6A: 23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ITO_A_IREA2020_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	6 / 12	LEU A 55 ALA A 76 LYS A 78 LEU A 122 GLY A 130 LEU A 177	None	0.69A	2itoA-2hw6A: 20.6	2itoA-2hw6A: 22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ITY_A_IREA2020_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	8 / 12	LEU A 55 GLY A 56 VAL A 63 ALA A 76 LYS A 78 LEU A 122 GLY A 130 LEU A 177	None	0.74A	2ityA-2hw6A: 20.8	2ityA-2hw6A: 22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IVU_A_ZD6A3015_0 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET PRECURSOR)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	6 / 12	LEU A 55 GLY A 56 VAL A 63 LYS A 78 LEU A 98 LEU A 122	None	0.54A	2ivuA-2hw6A: 20.9	2ivuA-2hw6A: 27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YFX_A_VGHA9000_1 (TYROSINE-PROTEIN KINASE RECEPTOR)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	4 / 8	LEU A 55 ALA A 76 GLY A 130 LEU A 177	None	0.53A	2yfxA-2hw6A: 19.8	2yfxA-2hw6A: 25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3C7Q_A_XINA1172_1 (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	6 / 12	LEU A 55 GLY A 56 ALA A 76 GLY A 130 LEU A 177 CYH A 190	None	0.57A	3c7qA-2hw6A: 19.4	3c7qA-2hw6A: 26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CS9_D_NILD600_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	4 / 6	LEU A 55 VAL A 63 LYS A 78 LEU A 177	None	0.71A	3cs9D-2hw6A: 18.6	3cs9D-2hw6A: 25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G0E_A_B49A9000_1 (MAST/STEM CELL GROWTH FACTOR RECEPTOR)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	6 / 11	LEU A 55 VAL A 63 ALA A 76 GLY A 130 LEU A 177 CYH A 190	None	0.58A	3g0eA-2hw6A: 19.4	3g0eA-2hw6A: 23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G0F_A_B49A9001_1 (MAST/STEM CELL GROWTH FACTOR RECEPTOR)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	6 / 11	LEU A 55 VAL A 63 ALA A 76 GLY A 130 LEU A 177 CYH A 190	None	0.68A	3g0fA-2hw6A: 20.3	3g0fA-2hw6A: 23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G0F_B_B49B9001_1 (MAST/STEM CELL GROWTH FACTOR RECEPTOR)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	6 / 10	LEU A 55 VAL A 63 ALA A 76 GLY A 130 LEU A 177 CYH A 190	None	0.57A	3g0fB-2hw6A: 20.4	3g0fB-2hw6A: 23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GP0_A_NILA1_2 (MITOGEN-ACTIVATED PROTEIN KINASE 11)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	4 / 7	LYS A 78 ARG A 90 LEU A 122 ILE A 189	None	0.81A	3gp0A-2hw6A: 20.6	3gp0A-2hw6A: 26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LXN_A_MI1A1_1 (NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	7 / 12	LEU A 55 GLY A 56 VAL A 63 ALA A 76 LYS A 78 SER A 131 LEU A 177	None	0.53A	3lxnA-2hw6A: 21.5	3lxnA-2hw6A: 27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	6 / 12	VAL A 63 ALA A 76 LYS A 78 LEU A 98 LEU A 108 PHE A 230	None	1.01A	3og7A-2hw6A: 20.9	3og7A-2hw6A: 26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UG2_A_IREA1_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	7 / 12	LEU A 55 VAL A 63 ALA A 76 LYS A 78 LEU A 122 GLY A 130 LEU A 177	None	0.75A	3ug2A-2hw6A: 19.9	3ug2A-2hw6A: 22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WZD_A_LEVA1201_1 (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	6 / 12	LEU A 55 VAL A 63 ALA A 76 GLY A 130 CYH A 190 PHE A 230	None	0.94A	3wzdA-2hw6A: 19.4	3wzdA-2hw6A: 26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WZE_A_BAXA1201_1 (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	7 / 12	LEU A 55 VAL A 63 ALA A 76 LEU A 98 GLY A 130 LEU A 161 HIS A 168	None	0.67A	3wzeA-2hw6A: 11.6	3wzeA-2hw6A: 26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WZE_A_BAXA1201_1 (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	7 / 12	LEU A 55 VAL A 63 ALA A 76 LYS A 78 LEU A 98 GLY A 130 HIS A 168	None	0.63A	3wzeA-2hw6A: 11.6	3wzeA-2hw6A: 26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WZE_A_BAXA1201_2 (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	5 / 8	LEU A 177 ILE A 189 CYH A 190 ASP A 191 PHE A 192	None	1.06A	3wzeA-2hw6A: 11.6	3wzeA-2hw6A: 26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AG8_A_AXIA2000_1 (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	7 / 12	LEU A 55 VAL A 63 ALA A 76 LYS A 78 GLY A 130 LEU A 177 CYH A 190	None	0.53A	4ag8A-2hw6A: 20.9	4ag8A-2hw6A: 26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AGC_A_AXIA2000_1 (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	6 / 12	LEU A 55 VAL A 63 ALA A 76 GLY A 130 LEU A 177 CYH A 190	None	0.37A	4agcA-2hw6A: 20.3	4agcA-2hw6A: 24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AGC_A_AXIA2000_1 (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	7 / 12	LEU A 55 VAL A 63 LYS A 78 LEU A 98 GLY A 130 LEU A 177 CYH A 190	None	0.62A	4agcA-2hw6A: 20.3	4agcA-2hw6A: 24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AGD_A_B49A2000_1 (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	5 / 11	LEU A 55 ALA A 76 GLY A 130 LEU A 177 CYH A 190	None	0.39A	4agdA-2hw6A: 19.9	4agdA-2hw6A: 24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ASD_A_BAXA1500_1 (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	8 / 12	LEU A 55 VAL A 63 ALA A 76 LYS A 78 LEU A 98 GLY A 130 LEU A 161 HIS A 168	None	0.77A	4asdA-2hw6A: 20.7	4asdA-2hw6A: 24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CKI_A_ADNA2022_1 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	7 / 11	LEU A 55 GLY A 56 VAL A 63 ALA A 76 GLY A 130 SER A 131 LEU A 177	None	0.47A	4ckiA-2hw6A: 20.4	4ckiA-2hw6A: 28.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CKJ_A_ADNA2014_1 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	6 / 10	LEU A 55 GLY A 56 VAL A 63 ALA A 76 SER A 131 LEU A 177	None	0.55A	4ckjA-2hw6A: 21.1	4ckjA-2hw6A: 27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G10_A_ACTA301_0 (GLUTATHIONE S-TRANSFERASE HOMOLOG)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	4 / 6	PRO A 295 ILE A 302 TYR A 257 TYR A 251	None	0.92A	4g10A-2hw6A: undetectable	4g10A-2hw6A: 20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4I22_A_IREA9001_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	9 / 12	LEU A 55 GLY A 56 VAL A 63 ALA A 76 LYS A 78 LEU A 122 GLY A 130 LEU A 177 ASP A 191	None	0.74A	4i22A-2hw6A: 19.7	4i22A-2hw6A: 22.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4IFG_A_1E8A601_1 (CALMODULIN-DOMAIN PROTEIN KINASE 1)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	6 / 12	GLY A 56 VAL A 63 ALA A 76 LEU A 110 LEU A 122 LEU A 177	None	0.47A	4ifgA-2hw6A: 22.6	4ifgA-2hw6A: 30.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4O0S_A_ADNA500_1 (AURORA KINASE A)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	7 / 11	LEU A 55 GLY A 56 VAL A 63 ALA A 76 LEU A 108 ASN A 175 LEU A 177	None	0.71A	4o0sA-2hw6A: 25.8	4o0sA-2hw6A: 31.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4O0U_A_ADNA501_1 (AURORA KINASE A)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	4 / 6	VAL A 63 ALA A 76 LEU A 108 LEU A 177	None	0.49A	4o0uA-2hw6A: 7.1	4o0uA-2hw6A: 30.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OR0_B_NPSB602_1 (SERUM ALBUMIN)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	5 / 9	ALA A 156 LEU A 158 LEU A 328 SER A 148 VAL A 333	None	1.17A	4or0B-2hw6A: undetectable	4or0B-2hw6A: 18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OTW_A_DB8A1101_2 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	3 / 3	LEU A 122 LEU A 127 ASN A 175	None	0.55A	4otwA-2hw6A: 19.5	4otwA-2hw6A: 23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QRC_A_0LIA802_2 (FIBROBLAST GROWTH FACTOR RECEPTOR 4)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	4 / 8	LEU A 55 VAL A 63 HIS A 168 LEU A 177	None	0.39A	4qrcA-2hw6A: 13.1	4qrcA-2hw6A: 22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QRC_A_0LIA802_2 (FIBROBLAST GROWTH FACTOR RECEPTOR 4)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	4 / 8	LEU A 55 VAL A 63 LYS A 78 LEU A 177	None	0.54A	4qrcA-2hw6A: 13.1	4qrcA-2hw6A: 22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	5 / 12	VAL A 63 ALA A 76 LYS A 78 LEU A 108 SER A 131	None	0.81A	4rzvB-2hw6A: 19.3	4rzvB-2hw6A: 26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TYJ_A_0LIA801_2 (FIBROBLAST GROWTH FACTOR RECEPTOR 4)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	4 / 6	LEU A 55 VAL A 63 ILE A 107 ILE A 189	None	0.51A	4tyjA-2hw6A: 20.7	4tyjA-2hw6A: 22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TYJ_A_0LIA801_2 (FIBROBLAST GROWTH FACTOR RECEPTOR 4)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	4 / 6	LEU A 55 VAL A 63 LYS A 78 ILE A 107	None	0.57A	4tyjA-2hw6A: 20.7	4tyjA-2hw6A: 22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4U0I_A_0LIA1001_2 (MAST/STEM CELL GROWTH FACTOR RECEPTOR KIT,MAST/STEM CELL GROWTH FACTOR RECEPTOR KIT)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	7 / 12	ALA A 76 LYS A 78 LEU A 98 GLY A 130 HIS A 168 LEU A 177 CYH A 190	None	0.76A	4u0iA-2hw6A: 20.8	4u0iA-2hw6A: 24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4U0I_A_0LIA1001_2 (MAST/STEM CELL GROWTH FACTOR RECEPTOR KIT,MAST/STEM CELL GROWTH FACTOR RECEPTOR KIT)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	7 / 12	LYS A 78 LEU A 98 GLY A 130 HIS A 168 LEU A 177 CYH A 190 PHE A 192	None	1.41A	4u0iA-2hw6A: 20.8	4u0iA-2hw6A: 24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4V01_A_0LIA1776_2 (FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	6 / 9	LEU A 55 VAL A 63 LYS A 78 ARG A 169 LEU A 177 ILE A 189	None	1.05A	4v01A-2hw6A: 19.5	4v01A-2hw6A: 25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4V01_B_0LIB1770_2 (FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	6 / 9	LEU A 55 VAL A 63 LYS A 78 ARG A 169 LEU A 177 ILE A 189	None	0.91A	4v01B-2hw6A: 20.1	4v01B-2hw6A: 25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4V04_B_0LIB1771_1 (FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	6 / 10	LEU A 55 VAL A 63 LYS A 78 ARG A 169 LEU A 177 ILE A 189	None	1.17A	4v04B-2hw6A: 19.9	4v04B-2hw6A: 25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XOY_A_DX4A401_0 (MITOGEN-ACTIVATED PROTEIN KINASE 1)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	4 / 6	ALA A 325 GLN A 326 LEU A 328 LEU A 243	None	1.10A	4xoyA-2hw6A: 21.1	4xoyA-2hw6A: 25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZAU_A_YY3A1101_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	5 / 8	LEU A 55 GLY A 56 VAL A 63 ALA A 76 GLY A 130	None	0.55A	4zauA-2hw6A: 20.4	4zauA-2hw6A: 21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZJ8_A_SUVA2001_2 (HUMAN OX1R FUSION PROTEIN TO P.ABYSII GLYCOGEN SYNTHASE)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	4 / 6	TRP A 299 ILE A 310 ILE A 176 VAL A 154	None	0.97A	4zj8A-2hw6A: 2.3	4zj8A-2hw6A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_G_SAMG301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	5 / 12	ALA A 324 ASP A 238 THR A 231 GLN A 233 GLY A 165	None	1.38A	5hfjG-2hw6A: undetectable	5hfjG-2hw6A: 20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HI2_A_BAXA801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	5 / 8	VAL A 63 ILE A 107 ILE A 166 ILE A 189 ASP A 191	None	1.24A	5hi2A-2hw6A: 22.2	5hi2A-2hw6A: 27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IZJ_G_AZ1G2_1 (CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA 47P-AZ1-DAR-DAR)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	4 / 7	GLY A 56 GLY A 58 VAL A 63 LYS A 78	None	0.29A	5izjA-2hw6A: 22.0	5izjA-2hw6A: 28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5J5X_B_AZ1B2_1 (CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA 47P-AZ1-DAL-DAR-DAR- DAR-DAR)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	4 / 7	GLY A 56 GLY A 58 VAL A 63 LYS A 78	None	0.28A	5j5xA-2hw6A: 22.5	5j5xA-2hw6A: 28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TE8_C_08JC602_1 (CYTOCHROME P450 3A4)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	4 / 7	LEU A 243 ALA A 155 ILE A 189 LEU A 171	None	0.88A	5te8C-2hw6A: undetectable	5te8C-2hw6A: 20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VCY_A_DB8A401_1 (MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	6 / 12	LEU A 55 VAL A 63 ALA A 76 LYS A 78 LEU A 122 GLY A 129	None	0.79A	5vcyA-2hw6A: 24.3	5vcyA-2hw6A: 27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XV7_A_EMHA705_1 (SERINE-ARGININE (SR) PROTEIN KINASE 1)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	5 / 12	LEU A 55 GLY A 56 VAL A 63 ALA A 76 PHE A 124	None	0.51A	5xv7A-2hw6A: 22.8	5xv7A-2hw6A: 12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y7P_E_CHDE401_0 (BILE SALT HYDROLASE)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	4 / 8	ILE A 107 LEU A 161 ALA A 324 LEU A 328	None	0.85A	5y7pE-2hw6A: undetectable	5y7pE-2hw6A: 20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y7Z_B_IREB401_0 (CYCLIN-G-ASSOCIATED KINASE)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	7 / 12	LEU A 55 ALA A 76 LYS A 78 GLY A 130 LEU A 177 CYH A 190 ASP A 191	None	0.93A	5y7zB-2hw6A: 11.7	5y7zB-2hw6A: 19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y7Z_B_IREB401_0 (CYCLIN-G-ASSOCIATED KINASE)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	8 / 12	LEU A 55 LYS A 78 GLU A 94 LEU A 122 GLY A 130 LEU A 177 CYH A 190 ASP A 191	None	1.12A	5y7zB-2hw6A: 11.7	5y7zB-2hw6A: 19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y9M_A_NIOA401_1 (CASEIN KINASE II SUBUNIT ALPHA')	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	4 / 8	LEU A 55 VAL A 63 LYS A 78 PHE A 124	None	0.77A	5y9mA-2hw6A: 20.5	5y9mA-2hw6A: 13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EXI_C_ADNC502_1 (ADENOSYLHOMOCYSTEINA SE)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	3 / 3	LEU A 322 GLY A 247 PHE A 294	None	0.61A	6exiC-2hw6A: undetectable	6exiC-2hw6A: 13.87

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MUO_A_ADNA1_1","AURORA-RELATED KINASE 1","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",6,"LEU A  55;GLY A  56;VAL A  63;ALA A  76;LEU A 108;LEU A 177","None","0.78A","1muoA-2hw6A:24.3","1muoA-2hw6A:30.54"],["1Q97_B_ADNB486_1","SR PROTEIN KINASE","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",4,"VAL A  63;ALA A  76;LEU A 108;PHE A 124","None","0.45A","1q97B-2hw6A:21.4","1q97B-2hw6A:26.39"],["1S8F_A_BEZA1501_0","RAS-RELATED PROTEIN RAB-9A","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",4,"ILE A 310;TRP A 299;LEU A 314;PRO A 259","None","1.20A","1s8fA-2hw6A:undetectable;1s8fB-2hw6A:undetectable","1s8fA-2hw6A:20.90;1s8fB-2hw6A:20.90"],["1UWH_B_BAXB1723_2","B-RAF PROTO-ONCOGENE SERINE\/THREONINE-PROTEIN KINASE","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",4,"VAL A 333;ILE A 107;ILE A 166;ASP A 159","None","0.86A","1uwhB-2hw6A:22.4","1uwhB-2hw6A:26.20"],["1UWJ_A_BAXA1723_2","B-RAF PROTO-ONCOGENE SERINE\/THREONINE-PROTEIN KINASE","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",4,"LYS A  78;LEU A  98;ILE A 107;ILE A 166","None","0.74A","1uwjA-2hw6A:22.3","1uwjA-2hw6A:26.20"],["1XBB_A_STIA1_1","TYROSINE-PROTEIN KINASE SYK","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",5,"LEU A  55;VAL A  63;ALA A  76;GLY A 130;LEU A 177","None","0.54A","1xbbA-2hw6A:22.0","1xbbA-2hw6A:23.91"],["2ITO_A_IREA2020_1","EPIDERMAL GROWTH FACTOR RECEPTOR","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",6,"LEU A  55;ALA A  76;LYS A  78;LEU A 122;GLY A 130;LEU A 177","None","0.69A","2itoA-2hw6A:20.6","2itoA-2hw6A:22.50"],["2ITY_A_IREA2020_1","EPIDERMAL GROWTH FACTOR RECEPTOR","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",8,"LEU A  55;GLY A  56;VAL A  63;ALA A  76;LYS A  78;LEU A 122;GLY A 130;LEU A 177","None","0.74A","2ityA-2hw6A:20.8","2ityA-2hw6A:22.56"],["2IVU_A_ZD6A3015_0","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET PRECURSOR","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",6,"LEU A  55;GLY A  56;VAL A  63;LYS A  78;LEU A  98;LEU A 122","None","0.54A","2ivuA-2hw6A:20.9","2ivuA-2hw6A:27.98"],["2YFX_A_VGHA9000_1","TYROSINE-PROTEIN KINASE RECEPTOR","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",4,"LEU A  55;ALA A  76;GLY A 130;LEU A 177","None","0.53A","2yfxA-2hw6A:19.8","2yfxA-2hw6A:25.22"],["3C7Q_A_XINA1172_1","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",6,"LEU A  55;GLY A  56;ALA A  76;GLY A 130;LEU A 177;CYH A 190","None","0.57A","3c7qA-2hw6A:19.4","3c7qA-2hw6A:26.53"],["3CS9_D_NILD600_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",4,"LEU A  55;VAL A  63;LYS A  78;LEU A 177","None","0.71A","3cs9D-2hw6A:18.6","3cs9D-2hw6A:25.68"],["3G0E_A_B49A9000_1","MAST\/STEM CELL GROWTH FACTOR RECEPTOR","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",6,"LEU A  55;VAL A  63;ALA A  76;GLY A 130;LEU A 177;CYH A 190","None","0.58A","3g0eA-2hw6A:19.4","3g0eA-2hw6A:23.58"],["3G0F_A_B49A9001_1","MAST\/STEM CELL GROWTH FACTOR RECEPTOR","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",6,"LEU A  55;VAL A  63;ALA A  76;GLY A 130;LEU A 177;CYH A 190","None","0.68A","3g0fA-2hw6A:20.3","3g0fA-2hw6A:23.58"],["3G0F_B_B49B9001_1","MAST\/STEM CELL GROWTH FACTOR RECEPTOR","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",6,"LEU A  55;VAL A  63;ALA A  76;GLY A 130;LEU A 177;CYH A 190","None","0.57A","3g0fB-2hw6A:20.4","3g0fB-2hw6A:23.58"],["3GP0_A_NILA1_2","MITOGEN-ACTIVATED PROTEIN KINASE 11","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",4,"LYS A  78;ARG A  90;LEU A 122;ILE A 189","None","0.81A","3gp0A-2hw6A:20.6","3gp0A-2hw6A:26.29"],["3LXN_A_MI1A1_1","NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",7,"LEU A  55;GLY A  56;VAL A  63;ALA A  76;LYS A  78;SER A 131;LEU A 177","None","0.53A","3lxnA-2hw6A:21.5","3lxnA-2hw6A:27.27"],["3OG7_A_032A1_1","AKAP9-BRAF FUSION PROTEIN","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",6,"VAL A  63;ALA A  76;LYS A  78;LEU A  98;LEU A 108;PHE A 230","None","1.01A","3og7A-2hw6A:20.9","3og7A-2hw6A:26.81"],["3UG2_A_IREA1_1","EPIDERMAL GROWTH FACTOR RECEPTOR","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",7,"LEU A  55;VAL A  63;ALA A  76;LYS A  78;LEU A 122;GLY A 130;LEU A 177","None","0.75A","3ug2A-2hw6A:19.9","3ug2A-2hw6A:22.34"],["3WZD_A_LEVA1201_1","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",6,"LEU A  55;VAL A  63;ALA A  76;GLY A 130;CYH A 190;PHE A 230","None","0.94A","3wzdA-2hw6A:19.4","3wzdA-2hw6A:26.21"],["3WZE_A_BAXA1201_1","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",7,"LEU A  55;VAL A  63;ALA A  76;LEU A  98;GLY A 130;LEU A 161;HIS A 168","None","0.67A","3wzeA-2hw6A:11.6","3wzeA-2hw6A:26.21"],["3WZE_A_BAXA1201_1","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",7,"LEU A  55;VAL A  63;ALA A  76;LYS A  78;LEU A  98;GLY A 130;HIS A 168","None","0.63A","3wzeA-2hw6A:11.6","3wzeA-2hw6A:26.21"],["3WZE_A_BAXA1201_2","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",5,"LEU A 177;ILE A 189;CYH A 190;ASP A 191;PHE A 192","None","1.06A","3wzeA-2hw6A:11.6","3wzeA-2hw6A:26.21"],["4AG8_A_AXIA2000_1","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",7,"LEU A  55;VAL A  63;ALA A  76;LYS A  78;GLY A 130;LEU A 177;CYH A 190","None","0.53A","4ag8A-2hw6A:20.9","4ag8A-2hw6A:26.93"],["4AGC_A_AXIA2000_1","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",6,"LEU A  55;VAL A  63;ALA A  76;GLY A 130;LEU A 177;CYH A 190","None","0.37A","4agcA-2hw6A:20.3","4agcA-2hw6A:24.94"],["4AGC_A_AXIA2000_1","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",7,"LEU A  55;VAL A  63;LYS A  78;LEU A  98;GLY A 130;LEU A 177;CYH A 190","None","0.62A","4agcA-2hw6A:20.3","4agcA-2hw6A:24.94"],["4AGD_A_B49A2000_1","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",5,"LEU A  55;ALA A  76;GLY A 130;LEU A 177;CYH A 190","None","0.39A","4agdA-2hw6A:19.9","4agdA-2hw6A:24.94"],["4ASD_A_BAXA1500_1","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",8,"LEU A  55;VAL A  63;ALA A  76;LYS A  78;LEU A  98;GLY A 130;LEU A 161;HIS A 168","None","0.77A","4asdA-2hw6A:20.7","4asdA-2hw6A:24.94"],["4CKI_A_ADNA2022_1","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",7,"LEU A  55;GLY A  56;VAL A  63;ALA A  76;GLY A 130;SER A 131;LEU A 177","None","0.47A","4ckiA-2hw6A:20.4","4ckiA-2hw6A:28.28"],["4CKJ_A_ADNA2014_1","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",6,"LEU A  55;GLY A  56;VAL A  63;ALA A  76;SER A 131;LEU A 177","None","0.55A","4ckjA-2hw6A:21.1","4ckjA-2hw6A:27.98"],["4G10_A_ACTA301_0","GLUTATHIONE S-TRANSFERASE HOMOLOG","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",4,"PRO A 295;ILE A 302;TYR A 257;TYR A 251","None","0.92A","4g10A-2hw6A:undetectable","4g10A-2hw6A:20.30"],["4I22_A_IREA9001_1","EPIDERMAL GROWTH FACTOR RECEPTOR","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",9,"LEU A  55;GLY A  56;VAL A  63;ALA A  76;LYS A  78;LEU A 122;GLY A 130;LEU A 177;ASP A 191","None","0.74A","4i22A-2hw6A:19.7","4i22A-2hw6A:22.50"],["4IFG_A_1E8A601_1","CALMODULIN-DOMAIN PROTEIN KINASE 1","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",6,"GLY A  56;VAL A  63;ALA A  76;LEU A 110;LEU A 122;LEU A 177","None","0.47A","4ifgA-2hw6A:22.6","4ifgA-2hw6A:30.02"],["4O0S_A_ADNA500_1","AURORA KINASE A","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",7,"LEU A  55;GLY A  56;VAL A  63;ALA A  76;LEU A 108;ASN A 175;LEU A 177","None","0.71A","4o0sA-2hw6A:25.8","4o0sA-2hw6A:31.06"],["4O0U_A_ADNA501_1","AURORA KINASE A","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",4,"VAL A  63;ALA A  76;LEU A 108;LEU A 177","None","0.49A","4o0uA-2hw6A:7.1","4o0uA-2hw6A:30.75"],["4OR0_B_NPSB602_1","SERUM ALBUMIN","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",5,"ALA A 156;LEU A 158;LEU A 328;SER A 148;VAL A 333","None","1.17A","4or0B-2hw6A:undetectable","4or0B-2hw6A:18.63"],["4OTW_A_DB8A1101_2","RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",3,"LEU A 122;LEU A 127;ASN A 175","None","0.55A","4otwA-2hw6A:19.5","4otwA-2hw6A:23.85"],["4QRC_A_0LIA802_2","FIBROBLAST GROWTH FACTOR RECEPTOR 4","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",4,"LEU A  55;VAL A  63;HIS A 168;LEU A 177","None","0.39A","4qrcA-2hw6A:13.1","4qrcA-2hw6A:22.19"],["4QRC_A_0LIA802_2","FIBROBLAST GROWTH FACTOR RECEPTOR 4","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",4,"LEU A  55;VAL A  63;LYS A  78;LEU A 177","None","0.54A","4qrcA-2hw6A:13.1","4qrcA-2hw6A:22.19"],["4RZV_B_032B801_1","SERINE\/THREONINE-PROTEIN KINASE B-RAF","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",5,"VAL A  63;ALA A  76;LYS A  78;LEU A 108;SER A 131","None","0.81A","4rzvB-2hw6A:19.3","4rzvB-2hw6A:26.96"],["4TYJ_A_0LIA801_2","FIBROBLAST GROWTH FACTOR RECEPTOR 4","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",4,"LEU A  55;VAL A  63;ILE A 107;ILE A 189","None","0.51A","4tyjA-2hw6A:20.7","4tyjA-2hw6A:22.45"],["4TYJ_A_0LIA801_2","FIBROBLAST GROWTH FACTOR RECEPTOR 4","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",4,"LEU A  55;VAL A  63;LYS A  78;ILE A 107","None","0.57A","4tyjA-2hw6A:20.7","4tyjA-2hw6A:22.45"],["4U0I_A_0LIA1001_2","MAST\/STEM CELL GROWTH FACTOR RECEPTOR KIT,MAST\/STEM CELL GROWTH FACTOR RECEPTOR KIT","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",7,"ALA A  76;LYS A  78;LEU A  98;GLY A 130;HIS A 168;LEU A 177;CYH A 190","None","0.76A","4u0iA-2hw6A:20.8","4u0iA-2hw6A:24.86"],["4U0I_A_0LIA1001_2","MAST\/STEM CELL GROWTH FACTOR RECEPTOR KIT,MAST\/STEM CELL GROWTH FACTOR RECEPTOR KIT","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",7,"LYS A  78;LEU A  98;GLY A 130;HIS A 168;LEU A 177;CYH A 190;PHE A 192","None","1.41A","4u0iA-2hw6A:20.8","4u0iA-2hw6A:24.86"],["4V01_A_0LIA1776_2","FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",6,"LEU A  55;VAL A  63;LYS A  78;ARG A 169;LEU A 177;ILE A 189","None","1.05A","4v01A-2hw6A:19.5","4v01A-2hw6A:25.66"],["4V01_B_0LIB1770_2","FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",6,"LEU A  55;VAL A  63;LYS A  78;ARG A 169;LEU A 177;ILE A 189","None","0.91A","4v01B-2hw6A:20.1","4v01B-2hw6A:25.66"],["4V04_B_0LIB1771_1","FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",6,"LEU A  55;VAL A  63;LYS A  78;ARG A 169;LEU A 177;ILE A 189","None","1.17A","4v04B-2hw6A:19.9","4v04B-2hw6A:25.66"],["4XOY_A_DX4A401_0","MITOGEN-ACTIVATED PROTEIN KINASE 1","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",4,"ALA A 325;GLN A 326;LEU A 328;LEU A 243","None","1.10A","4xoyA-2hw6A:21.1","4xoyA-2hw6A:25.61"],["4ZAU_A_YY3A1101_1","EPIDERMAL GROWTH FACTOR RECEPTOR","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",5,"LEU A  55;GLY A  56;VAL A  63;ALA A  76;GLY A 130","None","0.55A","4zauA-2hw6A:20.4","4zauA-2hw6A:21.92"],["4ZJ8_A_SUVA2001_2","HUMAN OX1R FUSION PROTEIN TO P.ABYSII GLYCOGEN SYNTHASE","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",4,"TRP A 299;ILE A 310;ILE A 176;VAL A 154","None","0.97A","4zj8A-2hw6A:2.3","4zj8A-2hw6A:20.00"],["5HFJ_G_SAMG301_0","ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA)","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",5,"ALA A 324;ASP A 238;THR A 231;GLN A 233;GLY A 165","None","1.38A","5hfjG-2hw6A:undetectable","5hfjG-2hw6A:20.78"],["5HI2_A_BAXA801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",5,"VAL A  63;ILE A 107;ILE A 166;ILE A 189;ASP A 191","None","1.24A","5hi2A-2hw6A:22.2","5hi2A-2hw6A:27.50"],["5IZJ_G_AZ1G2_1","CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA;47P-AZ1-DAR-DAR","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",4,"GLY A  56;GLY A  58;VAL A  63;LYS A  78","None","0.29A","5izjA-2hw6A:22.0","5izjA-2hw6A:28.35"],["5J5X_B_AZ1B2_1","CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA;47P-AZ1-DAL-DAR-DAR-DAR-DAR","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",4,"GLY A  56;GLY A  58;VAL A  63;LYS A  78","None","0.28A","5j5xA-2hw6A:22.5","5j5xA-2hw6A:28.35"],["5TE8_C_08JC602_1","CYTOCHROME P450 3A4","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",4,"LEU A 243;ALA A 155;ILE A 189;LEU A 171","None","0.88A","5te8C-2hw6A:undetectable","5te8C-2hw6A:20.32"],["5VCY_A_DB8A401_1","MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",6,"LEU A  55;VAL A  63;ALA A  76;LYS A  78;LEU A 122;GLY A 129","None","0.79A","5vcyA-2hw6A:24.3","5vcyA-2hw6A:27.50"],["5XV7_A_EMHA705_1","SERINE-ARGININE (SR) PROTEIN KINASE 1","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",5,"LEU A  55;GLY A  56;VAL A  63;ALA A  76;PHE A 124","None","0.51A","5xv7A-2hw6A:22.8","5xv7A-2hw6A:12.46"],["5Y7P_E_CHDE401_0","BILE SALT HYDROLASE","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",4,"ILE A 107;LEU A 161;ALA A 324;LEU A 328","None","0.85A","5y7pE-2hw6A:undetectable","5y7pE-2hw6A:20.92"],["5Y7Z_B_IREB401_0","CYCLIN-G-ASSOCIATED KINASE","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",7,"LEU A  55;ALA A  76;LYS A  78;GLY A 130;LEU A 177;CYH A 190;ASP A 191","None","0.93A","5y7zB-2hw6A:11.7","5y7zB-2hw6A:19.57"],["5Y7Z_B_IREB401_0","CYCLIN-G-ASSOCIATED KINASE","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",8,"LEU A  55;LYS A  78;GLU A  94;LEU A 122;GLY A 130;LEU A 177;CYH A 190;ASP A 191","None","1.12A","5y7zB-2hw6A:11.7","5y7zB-2hw6A:19.57"],["5Y9M_A_NIOA401_1","CASEIN KINASE II SUBUNIT ALPHA'","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",4,"LEU A  55;VAL A  63;LYS A  78;PHE A 124","None","0.77A","5y9mA-2hw6A:20.5","5y9mA-2hw6A:13.03"],["6EXI_C_ADNC502_1","ADENOSYLHOMOCYSTEINASE","2hw6","MAP KINASE-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 1","Homo sapiens",3,"LEU A 322;GLY A 247;PHE A 294","None","0.61A","6exiC-2hw6A:undetectable","6exiC-2hw6A:13.87"]]