SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hwj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 2hwj HYPOTHETICAL PROTEIN
ATU1540
(Agrobacterium
fabrum) 		4 / 6 HIS A 196
LEU A 197
TRP A 161
PHE A 164
 None
 1.20A 1ibgH-2hwjA:
undetectable		 1ibgH-2hwjA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 2hwj HYPOTHETICAL PROTEIN
ATU1540
(Agrobacterium
fabrum) 		3 / 3 ASP A  97
ILE A 124
VAL A  56
 None
 0.65A 2avvD-2hwjA:
undetectable		 2avvD-2hwjA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 2hwj HYPOTHETICAL PROTEIN
ATU1540
(Agrobacterium
fabrum) 		5 / 11 PHE A 136
ARG A 137
ALA A 162
LEU A 143
GLU A  28
 None
 1.08A 2bxeB-2hwjA:
2.1		 2bxeB-2hwjA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2hwj HYPOTHETICAL PROTEIN
ATU1540
(Agrobacterium
fabrum) 		5 / 12 PHE A  91
PHE A 159
ALA A  23
ILE A 124
MET A 103
 None
 1.50A 3ld6B-2hwjA:
undetectable		 3ld6B-2hwjA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 2hwj HYPOTHETICAL PROTEIN
ATU1540
(Agrobacterium
fabrum) 		4 / 5 HIS A  69
PHE A 156
LEU A 131
PRO A 125
 None
 1.02A 4o8zA-2hwjA:
undetectable		 4o8zA-2hwjA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2hwj HYPOTHETICAL PROTEIN
ATU1540
(Agrobacterium
fabrum) 		5 / 8 LEU A 182
ALA A 142
LEU A 139
LEU A 165
ALA A 146
 None
 1.03A 4z90A-2hwjA:
undetectable
4z90B-2hwjA:
undetectable
4z90C-2hwjA:
undetectable
4z90D-2hwjA:
undetectable
4z90E-2hwjA:
undetectable		 4z90A-2hwjA:
20.12
4z90B-2hwjA:
20.12
4z90C-2hwjA:
20.12
4z90D-2hwjA:
20.12
4z90E-2hwjA:
20.12