SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hwk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2hwk HELICASE NSP2
(Venezuelan
equine
encephalitis
virus) 		5 / 12 ILE A 732
HIS A 689
HIS A 608
LEU A 780
TYR A 784
 None
 1.18A 1fm6X-2hwkA:
undetectable		 1fm6X-2hwkA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2hwk HELICASE NSP2
(Venezuelan
equine
encephalitis
virus) 		5 / 12 PHE A 759
HIS A 689
HIS A 608
LEU A 780
TYR A 784
 None
 1.34A 1fm6X-2hwkA:
undetectable		 1fm6X-2hwkA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2hwk HELICASE NSP2
(Venezuelan
equine
encephalitis
virus) 		4 / 4 LEU A 758
VAL A 718
CYH A 717
ALA A 707
 None
 1.25A 1mz9E-2hwkA:
undetectable		 1mz9E-2hwkA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2hwk HELICASE NSP2
(Venezuelan
equine
encephalitis
virus) 		4 / 8 PHE A 761
THR A 704
LEU A 700
VAL A 745
 None
 0.89A 1t86A-2hwkA:
undetectable		 1t86A-2hwkA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 2hwk HELICASE NSP2
(Venezuelan
equine
encephalitis
virus) 		4 / 8 HIS A 696
VAL A 681
LEU A 703
THR A 704
 None
 0.77A 2gehA-2hwkA:
undetectable		 2gehA-2hwkA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2hwk HELICASE NSP2
(Venezuelan
equine
encephalitis
virus) 		4 / 5 LEU A 780
ILE A 733
GLY A 721
HIS A 689
 None
 0.94A 2otfA-2hwkA:
undetectable		 2otfA-2hwkA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 2hwk HELICASE NSP2
(Venezuelan
equine
encephalitis
virus) 		4 / 7 VAL A 679
HIS A 696
THR A 704
LEU A 700
 None
 1.19A 3arrA-2hwkA:
undetectable		 3arrA-2hwkA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 2hwk HELICASE NSP2
(Venezuelan
equine
encephalitis
virus) 		3 / 3 GLU A 756
HIS A 689
HIS A 614
 None
 0.93A 3co4A-2hwkA:
undetectable		 3co4A-2hwkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2hwk HELICASE NSP2
(Venezuelan
equine
encephalitis
virus) 		4 / 7 GLY A 525
VAL A 602
ILE A 597
VAL A 582
 None
 0.78A 3fi0E-2hwkA:
undetectable		 3fi0E-2hwkA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hwk HELICASE NSP2
(Venezuelan
equine
encephalitis
virus) 		5 / 9 ALA A 728
ILE A 698
ASP A 726
THR A 704
ILE A 733
 None
 1.37A 3hbbB-2hwkA:
undetectable		 3hbbB-2hwkA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hwk HELICASE NSP2
(Venezuelan
equine
encephalitis
virus) 		4 / 7 PHE A 533
VAL A 563
LEU A 566
SER A 567
 None
 0.88A 3hs6B-2hwkA:
undetectable		 3hs6B-2hwkA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2hwk HELICASE NSP2
(Venezuelan
equine
encephalitis
virus) 		3 / 3 ASN A 517
ASP A 529
ARG A 738
 None
 0.92A 3k13A-2hwkA:
undetectable		 3k13A-2hwkA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2hwk HELICASE NSP2
(Venezuelan
equine
encephalitis
virus) 		5 / 11 THR A 704
ALA A 707
LEU A 711
SER A 719
VAL A 643
 None
 1.49A 4claA-2hwkA:
undetectable		 4claA-2hwkA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hwk HELICASE NSP2
(Venezuelan
equine
encephalitis
virus) 		4 / 5 VAL A 563
LEU A 566
SER A 567
MET A 585
 None
 1.01A 4e1gA-2hwkA:
undetectable		 4e1gA-2hwkA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 2hwk HELICASE NSP2
(Venezuelan
equine
encephalitis
virus) 		5 / 12 LEU A 703
ALA A 657
ILE A 677
ASP A 670
GLY A 669
 None
 1.28A 4hfpB-2hwkA:
undetectable		 4hfpB-2hwkA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2hwk HELICASE NSP2
(Venezuelan
equine
encephalitis
virus) 		4 / 8 PHE A 761
THR A 704
LEU A 700
VAL A 745
 None
 0.91A 4l4bA-2hwkA:
undetectable		 4l4bA-2hwkA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2hwk HELICASE NSP2
(Venezuelan
equine
encephalitis
virus) 		4 / 6 LEU A 776
TYR A 774
GLU A 730
TYR A 724
 None
 1.25A 4z4gA-2hwkA:
undetectable		 4z4gA-2hwkA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2hwk HELICASE NSP2
(Venezuelan
equine
encephalitis
virus) 		5 / 12 LEU A 519
PHE A 524
GLY A 490
THR A 495
MET A 493
 None
 0.95A 4ze2A-2hwkA:
undetectable		 4ze2A-2hwkA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2hwk HELICASE NSP2
(Venezuelan
equine
encephalitis
virus) 		5 / 12 LEU A 519
PHE A 524
GLY A 580
THR A 495
MET A 493
 None
 1.10A 4ze2A-2hwkA:
undetectable		 4ze2A-2hwkA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2hwk HELICASE NSP2
(Venezuelan
equine
encephalitis
virus) 		5 / 12 PHE A 759
HIS A 689
ILE A 698
LEU A 780
TYR A 784
 None
 1.28A 5ycpA-2hwkA:
undetectable		 5ycpA-2hwkA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 2hwk HELICASE NSP2
(Venezuelan
equine
encephalitis
virus) 		4 / 8 VAL A 602
HIS A 688
GLU A 694
CYH A 693
 None
 1.09A 6gneB-2hwkA:
undetectable		 6gneB-2hwkA:
21.48