SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hwv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2O4L_A_TPVA403_1 (PROTEASE)	2hwv	DNA-BINDING RESPONSE REGULATOR VICR (Enterococcus faecalis)	5 / 12	LEU A 139 ALA A 169 GLY A 173 PRO A 231 ILE A 136	None	1.18A	2o4lA-2hwvA: undetectable	2o4lA-2hwvA: 23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QEU_A_ACTA141_0 (PUTATIVE CARBOXYMUCONOLACTONE DECARBOXYLASE)	2hwv	DNA-BINDING RESPONSE REGULATOR VICR (Enterococcus faecalis)	3 / 3	VAL A 194 ASP A 193 GLU A 179	SO4 A 101 (-4.9A) SO4 A 102 (-3.1A) SO4 A 101 (-4.9A)	0.73A	2qeuA-2hwvA: undetectable	2qeuA-2hwvA: 19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QEU_C_ACTC141_0 (PUTATIVE CARBOXYMUCONOLACTONE DECARBOXYLASE)	2hwv	DNA-BINDING RESPONSE REGULATOR VICR (Enterococcus faecalis)	3 / 3	VAL A 194 ASP A 193 GLU A 179	SO4 A 101 (-4.9A) SO4 A 102 (-3.1A) SO4 A 101 (-4.9A)	0.70A	2qeuC-2hwvA: undetectable	2qeuC-2hwvA: 19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NKV_B_AERB601_2 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	2hwv	DNA-BINDING RESPONSE REGULATOR VICR (Enterococcus faecalis)	4 / 5	ARG A 202 ASP A 198 GLU A 161 VAL A 185	None	1.47A	4nkvB-2hwvA: undetectable	4nkvB-2hwvA: 13.59

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2O4L_A_TPVA403_1","PROTEASE","2hwv","DNA-BINDING RESPONSE REGULATOR VICR","Enterococcus faecalis",5,"LEU A 139;ALA A 169;GLY A 173;PRO A 231;ILE A 136","None","1.18A","2o4lA-2hwvA:undetectable","2o4lA-2hwvA:23.02"],["2QEU_A_ACTA141_0","PUTATIVE CARBOXYMUCONOLACTONE DECARBOXYLASE","2hwv","DNA-BINDING RESPONSE REGULATOR VICR","Enterococcus faecalis",3,"VAL A 194;ASP A 193;GLU A 179","SO4 A 101 (-4.9A);SO4 A 102 (-3.1A);SO4 A 101 (-4.9A)","0.73A","2qeuA-2hwvA:undetectable","2qeuA-2hwvA:19.71"],["2QEU_C_ACTC141_0","PUTATIVE CARBOXYMUCONOLACTONE DECARBOXYLASE","2hwv","DNA-BINDING RESPONSE REGULATOR VICR","Enterococcus faecalis",3,"VAL A 194;ASP A 193;GLU A 179","SO4 A 101 (-4.9A);SO4 A 102 (-3.1A);SO4 A 101 (-4.9A)","0.70A","2qeuC-2hwvA:undetectable","2qeuC-2hwvA:19.71"],["4NKV_B_AERB601_2","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","2hwv","DNA-BINDING RESPONSE REGULATOR VICR","Enterococcus faecalis",4,"ARG A 202;ASP A 198;GLU A 161;VAL A 185","None","1.47A","4nkvB-2hwvA:undetectable","4nkvB-2hwvA:13.59"]]