SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hwx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 2hwx TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		5 / 12 LEU A1273
LEU A1266
SER A1320
VAL A1275
LEU A1283
 None
 1.24A 1db1A-2hwxA:
undetectable		 1db1A-2hwxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2hwx TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		3 / 3 ARG A1321
VAL A1274
GLY A1332
 None
 0.50A 2avvE-2hwxA:
undetectable		 2avvE-2hwxA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 2hwx TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		5 / 12 ILE A1256
LEU A1283
ASN A1281
VAL A1303
ILE A1278
 None
 1.16A 2vn0A-2hwxA:
undetectable		 2vn0A-2hwxA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 2hwx TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		5 / 11 LEU A1277
ASN A1333
LEU A1314
ILE A1280
PRO A1250
 None
 1.30A 3a50B-2hwxA:
undetectable		 3a50B-2hwxA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hwx TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		4 / 7 LEU A1266
ARG A1321
ILE A1338
PHE A1318
 None
 0.99A 3ln1C-2hwxA:
undetectable		 3ln1C-2hwxA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hwx TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		4 / 5 LEU A1266
ARG A1321
ILE A1338
PHE A1318
 None
 0.99A 3ln1D-2hwxA:
undetectable		 3ln1D-2hwxA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 2hwx TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		3 / 3 ARG A1269
LEU A1266
GLU A1267
 None
 0.73A 4l3gF-2hwxA:
undetectable		 4l3gF-2hwxA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2hwx TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		5 / 9 ALA A1263
PHE A1313
VAL A1279
GLY A1254
VAL A1275
 None
 1.25A 4r20B-2hwxA:
undetectable		 4r20B-2hwxA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 2hwx TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		4 / 6 GLU A1334
ALA A1327
LEU A1328
TYR A1363
 None
 0.97A 5phhA-2hwxA:
undetectable		 5phhA-2hwxA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2hwx TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens) 		3 / 3 MET A1239
ASP A1366
ARG A1244
 None
 1.16A 5z6kA-2hwxA:
undetectable		 5z6kA-2hwxA:
17.78