SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hwy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)
2hwy PROTEIN SMG5
(Homo
sapiens)
4 / 6 HIS A 866
LEU A 864
LEU A 868
PRO A 869
None
1.26A 1hz4A-2hwyA:
undetectable
1hz4A-2hwyA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
2hwy PROTEIN SMG5
(Homo
sapiens)
3 / 3 HIS A 899
ASP A 860
ASN A1004
None
0.88A 1wg8B-2hwyA:
3.6
1wg8B-2hwyA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)
2hwy PROTEIN SMG5
(Homo
sapiens)
5 / 11 VAL A 882
ILE A 871
GLY A 905
ILE A 906
ILE A 920
None
1.07A 2idwA-2hwyA:
undetectable
2idwA-2hwyA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)
2hwy PROTEIN SMG5
(Homo
sapiens)
5 / 12 VAL A 882
ILE A 871
GLY A 905
ILE A 906
ILE A 920
None
1.00A 3d1zA-2hwyA:
undetectable
3d1zA-2hwyA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)
2hwy PROTEIN SMG5
(Homo
sapiens)
5 / 11 VAL A 882
ILE A 871
GLY A 905
ILE A 906
ILE A 920
None
1.02A 3lzvB-2hwyA:
undetectable
3lzvB-2hwyA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)
2hwy PROTEIN SMG5
(Homo
sapiens)
5 / 10 VAL A 882
ILE A 871
GLY A 905
ILE A 906
ILE A 920
None
0.98A 3nu6A-2hwyA:
undetectable
3nu6A-2hwyA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)
2hwy PROTEIN SMG5
(Homo
sapiens)
5 / 10 VAL A 882
ILE A 871
GLY A 905
ILE A 906
ILE A 920
None
1.03A 3nujA-2hwyA:
undetectable
3nujA-2hwyA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)
2hwy PROTEIN SMG5
(Homo
sapiens)
5 / 12 LEU A 895
LEU A 892
GLY A 891
THR A 887
ASP A 860
None
1.04A 4c9lA-2hwyA:
undetectable
4c9lA-2hwyA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)
2hwy PROTEIN SMG5
(Homo
sapiens)
5 / 12 LEU A 895
LEU A 892
GLY A 891
THR A 887
ASP A 860
None
1.03A 4c9lB-2hwyA:
undetectable
4c9lB-2hwyA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)
2hwy PROTEIN SMG5
(Homo
sapiens)
5 / 12 LEU A 895
LEU A 892
GLY A 891
THR A 887
ASP A 860
None
1.07A 4c9oA-2hwyA:
undetectable
4c9oA-2hwyA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)
2hwy PROTEIN SMG5
(Homo
sapiens)
5 / 12 LEU A 895
LEU A 892
GLY A 891
THR A 887
ASP A 860
None
1.05A 4c9oB-2hwyA:
undetectable
4c9oB-2hwyA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)
2hwy PROTEIN SMG5
(Homo
sapiens)
5 / 12 VAL A 882
ILE A 871
GLY A 905
ILE A 906
ILE A 920
None
0.98A 4jecB-2hwyA:
undetectable
4jecB-2hwyA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)
2hwy PROTEIN SMG5
(Homo
sapiens)
5 / 12 VAL A 882
ILE A 871
GLY A 905
ILE A 906
ILE A 920
None
0.97A 5kqyA-2hwyA:
undetectable
5kqyA-2hwyA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)
2hwy PROTEIN SMG5
(Homo
sapiens)
5 / 12 VAL A 882
ILE A 871
GLY A 905
ILE A 906
ILE A 920
None
1.02A 6dh3B-2hwyA:
undetectable
6dh3B-2hwyA:
20.59