SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hx0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 2hx0 PUTATIVE DNA-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 10 ALA A  40
GLU A 117
LEU A  37
ARG A 141
LEU A  28
 None
 1.23A 1a52A-2hx0A:
undetectable		 1a52A-2hx0A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 2hx0 PUTATIVE DNA-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 10 ALA A  40
GLU A 117
LEU A  37
ARG A 141
LEU A  28
 None
 1.23A 1a52B-2hx0A:
undetectable		 1a52B-2hx0A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 2hx0 PUTATIVE DNA-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 10 ALA A  40
GLU A 117
LEU A  37
ARG A 141
LEU A  28
 None
 1.29A 1gwrA-2hx0A:
undetectable		 1gwrA-2hx0A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_B_ESTB600_1
(OESTROGEN RECEPTOR)		 2hx0 PUTATIVE DNA-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 9 ALA A  40
GLU A 117
LEU A  37
ARG A 141
LEU A  28
 None
 1.32A 1gwrB-2hx0A:
undetectable		 1gwrB-2hx0A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 2hx0 PUTATIVE DNA-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 10 ALA A  40
GLU A 117
LEU A  37
ARG A 141
LEU A  28
 None
 1.30A 1pcgA-2hx0A:
undetectable		 1pcgA-2hx0A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 2hx0 PUTATIVE DNA-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 10 ALA A  40
GLU A 117
LEU A  37
ARG A 141
LEU A  28
 None
 1.22A 1pcgB-2hx0A:
undetectable		 1pcgB-2hx0A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2hx0 PUTATIVE DNA-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 11 ALA A  40
GLU A 117
LEU A  37
ARG A 141
LEU A  28
 None
 1.30A 3uudA-2hx0A:
undetectable		 3uudA-2hx0A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_B_ESTB600_1
(ESTROGEN RECEPTOR)		 2hx0 PUTATIVE DNA-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 10 ALA A  40
GLU A 117
LEU A  37
ARG A 141
LEU A  28
 None
 1.29A 3uudB-2hx0A:
undetectable		 3uudB-2hx0A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 2hx0 PUTATIVE DNA-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 11 ALA A  40
GLU A 117
LEU A  37
ARG A 141
LEU A  28
 None
 1.26A 4zn7B-2hx0A:
undetectable		 4zn7B-2hx0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 2hx0 PUTATIVE DNA-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 9 ALA A  40
GLU A 117
LEU A  37
ARG A 141
LEU A  28
 None
 1.27A 5dx3B-2hx0A:
undetectable		 5dx3B-2hx0A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 2hx0 PUTATIVE DNA-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 10 ALA A  40
GLU A 117
LEU A  37
ARG A 141
LEU A  28
 None
 1.30A 5dxbA-2hx0A:
undetectable		 5dxbA-2hx0A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 2hx0 PUTATIVE DNA-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 10 ALA A  40
GLU A 117
LEU A  37
ARG A 141
LEU A  28
 None
 1.26A 5dxeB-2hx0A:
undetectable		 5dxeB-2hx0A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2hx0 PUTATIVE DNA-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 11 ALA A  40
GLU A 117
LEU A  37
ARG A 141
LEU A  28
 None
 1.26A 5dxgB-2hx0A:
undetectable		 5dxgB-2hx0A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2hx0 PUTATIVE DNA-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 10 ALA A  40
GLU A 117
LEU A  37
ARG A 141
LEU A  28
 None
 1.29A 5hyrA-2hx0A:
undetectable		 5hyrA-2hx0A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2hx0 PUTATIVE DNA-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 11 ALA A  40
GLU A 117
LEU A  37
ARG A 141
LEU A  28
 None
 1.27A 5hyrB-2hx0A:
undetectable		 5hyrB-2hx0A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2hx0 PUTATIVE DNA-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 8 LEU A 113
LEU A 111
LEU A  85
MET A 101
LEU A  28
 None
 1.39A 5jqbA-2hx0A:
undetectable
5jqbB-2hx0A:
undetectable		 5jqbA-2hx0A:
16.92
5jqbB-2hx0A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2hx0 PUTATIVE DNA-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 11 LEU A  65
GLY A 104
LEU A  97
ARG A  55
THR A  62
 None
 0.95A 5o96G-2hx0A:
undetectable		 5o96G-2hx0A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGD_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2hx0 PUTATIVE DNA-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 9 ALA A  40
GLU A 117
LEU A  37
ARG A 141
LEU A  28
 None
 1.34A 5wgdA-2hx0A:
undetectable		 5wgdA-2hx0A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2hx0 PUTATIVE DNA-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 9 ALA A  40
GLU A 117
LEU A  37
ARG A 141
LEU A  28
 None
 1.27A 5wgqA-2hx0A:
undetectable		 5wgqA-2hx0A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2hx0 PUTATIVE DNA-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 10 ALA A  40
GLU A 117
LEU A  37
ARG A 141
LEU A  28
 None
 1.30A 5wgqB-2hx0A:
undetectable		 5wgqB-2hx0A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 2hx0 PUTATIVE DNA-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 10 ALA A  40
GLU A 117
LEU A  37
ARG A 141
LEU A  28
 None
 1.29A 6cbzB-2hx0A:
undetectable		 6cbzB-2hx0A:
23.39