SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hx5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 2hx5 HYPOTHETICAL PROTEIN
(Prochlorococcus
marinus) 		4 / 4 LEU A  41
SER A  40
TYR A  44
LEU A  46
 ETX  A 152 ( 4.1A)
None
None
ETX  A 152 ( 4.7A)
 1.12A 1xz1A-2hx5A:
undetectable		 1xz1A-2hx5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 2hx5 HYPOTHETICAL PROTEIN
(Prochlorococcus
marinus) 		4 / 4 LEU A  41
SER A  40
TYR A  44
LEU A  46
 ETX  A 152 ( 4.1A)
None
None
ETX  A 152 ( 4.7A)
 1.12A 1xz3A-2hx5A:
undetectable		 1xz3A-2hx5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 2hx5 HYPOTHETICAL PROTEIN
(Prochlorococcus
marinus) 		5 / 9 VAL A 101
LEU A 140
SER A  40
ILE A 136
ILE A  69
 None
 1.17A 3cv9A-2hx5A:
undetectable		 3cv9A-2hx5A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 2hx5 HYPOTHETICAL PROTEIN
(Prochlorococcus
marinus) 		4 / 6 ILE A 136
HIS A 119
PRO A  91
LEU A 140
 None
 1.07A 3oi8A-2hx5A:
undetectable		 3oi8A-2hx5A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 2hx5 HYPOTHETICAL PROTEIN
(Prochlorococcus
marinus) 		5 / 12 ILE A 117
ILE A 136
PRO A 133
LEU A  41
VAL A 101
 None
None
None
ETX  A 152 ( 4.1A)
None
 1.07A 4kfjB-2hx5A:
undetectable		 4kfjB-2hx5A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hx5 HYPOTHETICAL PROTEIN
(Prochlorococcus
marinus) 		3 / 3 LEU A  66
PRO A  67
ARG A  93
 ETX  A 153 (-4.5A)
ETX  A 153 ( 4.4A)
None
 0.73A 4klrB-2hx5A:
undetectable		 4klrB-2hx5A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2hx5 HYPOTHETICAL PROTEIN
(Prochlorococcus
marinus) 		4 / 7 ARG A 118
PHE A  99
LEU A 140
SER A  40
 None
 1.11A 5uxcA-2hx5A:
undetectable		 5uxcA-2hx5A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2hx5 HYPOTHETICAL PROTEIN
(Prochlorococcus
marinus) 		3 / 3 LEU A 140
GLY A 135
PHE A  52
 None
None
ETX  A 152 (-4.3A)
 0.66A 6exiC-2hx5A:
undetectable		 6exiC-2hx5A:
21.23