SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hxd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 2hxd DCTP DEAMINASE,
DUMP-FORMING
(Methanocaldococc
us
jannaschii) 		4 / 8 ALA A 145
VAL A 191
THR A 143
THR A 100
 None
None
DUP  A 206 (-4.5A)
None
 1.18A 2kotB-2hxdA:
undetectable		 2kotB-2hxdA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 2hxd DCTP DEAMINASE,
DUMP-FORMING
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 155
GLY A  37
ILE A  41
VAL A  67
ILE A  65
 None
 0.94A 3oxcB-2hxdA:
undetectable		 3oxcB-2hxdA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2hxd DCTP DEAMINASE,
DUMP-FORMING
(Methanocaldococc
us
jannaschii) 		3 / 3 HIS A 128
VAL A  67
LEU A 125
 None
 0.75A 4m2vA-2hxdA:
undetectable		 4m2vA-2hxdA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2hxd DCTP DEAMINASE,
DUMP-FORMING
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A  65
GLY A  98
THR A 100
VAL A  34
 None
 0.75A 4r20A-2hxdA:
undetectable		 4r20A-2hxdA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hxd DCTP DEAMINASE,
DUMP-FORMING
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A 161
VAL A  12
ILE A 104
PHE A  22
 None
 0.98A 5hieC-2hxdA:
undetectable		 5hieC-2hxdA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2hxd DCTP DEAMINASE,
DUMP-FORMING
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A  42
ILE A  59
VAL A  96
ASP A  38
ILE A  65
 None
 1.01A 5lg3A-2hxdA:
undetectable		 5lg3A-2hxdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2hxd DCTP DEAMINASE,
DUMP-FORMING
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  42
ILE A  59
VAL A  96
ASP A  38
ILE A  65
 None
 0.99A 5lg3E-2hxdA:
undetectable		 5lg3E-2hxdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2hxd DCTP DEAMINASE,
DUMP-FORMING
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A  42
ILE A  59
VAL A  96
ASP A  38
ILE A  65
 None
 1.01A 5lg3F-2hxdA:
undetectable		 5lg3F-2hxdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2hxd DCTP DEAMINASE,
DUMP-FORMING
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A  42
ILE A  59
VAL A  96
ASP A  38
ILE A  65
 None
 0.98A 5lg3G-2hxdA:
undetectable		 5lg3G-2hxdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2hxd DCTP DEAMINASE,
DUMP-FORMING
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A  42
ILE A  59
VAL A  96
ASP A  38
ILE A  65
 None
 0.95A 5lg3H-2hxdA:
undetectable		 5lg3H-2hxdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2hxd DCTP DEAMINASE,
DUMP-FORMING
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  42
ILE A  59
VAL A  96
ASP A  38
ILE A  65
 None
 0.98A 5lg3J-2hxdA:
undetectable		 5lg3J-2hxdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2hxd DCTP DEAMINASE,
DUMP-FORMING
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 142
VAL A  34
ILE A  65
LEU A 125
VAL A  67
 DUP  A 206 (-4.3A)
None
None
None
None
 0.99A 5mueA-2hxdA:
undetectable		 5mueA-2hxdA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 2hxd DCTP DEAMINASE,
DUMP-FORMING
(Methanocaldococc
us
jannaschii) 		4 / 7 LEU A 106
PHE A  22
GLY A  28
LEU A   3
 None
 0.67A 6eu9D-2hxdA:
undetectable		 6eu9D-2hxdA:
19.60