SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hxg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 10 GLY A  54
SER A  84
GLY A  92
ALA A  86
ILE A  90
 None
 1.11A 1c9sL-2hxgA:
undetectable
1c9sV-2hxgA:
undetectable		 1c9sL-2hxgA:
9.60
1c9sV-2hxgA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		6 / 12 ALA A 441
GLU A 472
ILE A 473
ARG A 463
LEU A 459
THR A 437
 None
 1.22A 1d1gA-2hxgA:
undetectable		 1d1gA-2hxgA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		4 / 6 ILE A 259
GLU A 255
ASP A 377
PRO A 379
 None
 1.05A 1ditH-2hxgA:
undetectable
1ditP-2hxgA:
undetectable		 1ditH-2hxgA:
19.88
1ditP-2hxgA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		4 / 4 ARG A 295
ALA A 257
ALA A 228
GLU A 232
 None
 1.21A 1e7bB-2hxgA:
undetectable		 1e7bB-2hxgA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 VAL A 293
GLY A 290
LEU A 288
PHE A 303
GLU A 306
 None
None
None
None
MN  A 501 (-2.8A)
 1.45A 1iolA-2hxgA:
3.9		 1iolA-2hxgA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 ASP A 308
ILE A 317
LEU A 176
TYR A 403
THR A 191
 None
 1.25A 1jomA-2hxgA:
undetectable		 1jomA-2hxgA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 12 GLY A 224
GLU A 232
GLU A 260
ALA A 257
LEU A 261
 None
 1.03A 1mjqC-2hxgA:
undetectable
1mjqD-2hxgA:
undetectable		 1mjqC-2hxgA:
12.32
1mjqD-2hxgA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 10 GLU A 232
GLU A 260
ALA A 257
LEU A 261
GLY A 224
 None
 1.06A 1mjqG-2hxgA:
undetectable
1mjqH-2hxgA:
undetectable		 1mjqG-2hxgA:
12.32
1mjqH-2hxgA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 12 GLY A 224
GLU A 232
GLU A 260
ALA A 257
LEU A 261
 None
 1.03A 1mjqI-2hxgA:
undetectable
1mjqJ-2hxgA:
undetectable		 1mjqI-2hxgA:
12.32
1mjqJ-2hxgA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		3 / 3 GLU A 333
HIS A 350
HIS A 450
 MN  A 501 (-2.6A)
MN  A 501 (-3.3A)
MN  A 501 (-3.6A)
 0.60A 1oe2A-2hxgA:
undetectable		 1oe2A-2hxgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 GLY A  92
ALA A  86
ILE A  90
GLY A  54
SER A  84
 None
 1.14A 1utdS-2hxgA:
undetectable
1utdT-2hxgA:
undetectable		 1utdS-2hxgA:
9.60
1utdT-2hxgA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		4 / 6 LEU A 396
TYR A 403
ILE A 471
GLY A 203
 None
 0.92A 2du8A-2hxgA:
undetectable		 2du8A-2hxgA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		4 / 6 LEU A 396
TYR A 403
ILE A 471
GLY A 203
 None
 0.94A 2du8B-2hxgA:
undetectable		 2du8B-2hxgA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		4 / 7 TRP A 429
GLY A 389
THR A 388
PHE A 453
 None
 1.13A 2qx4A-2hxgA:
3.3
2qx4B-2hxgA:
3.6		 2qx4A-2hxgA:
18.53
2qx4B-2hxgA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 12 VAL A 218
THR A 276
VAL A 293
GLY A 290
ALA A 292
 None
 1.14A 2x2iC-2hxgA:
undetectable		 2x2iC-2hxgA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 8 MET A 321
LEU A 396
ILE A 471
LEU A 405
LEU A 314
 None
 1.36A 2xfhA-2hxgA:
undetectable		 2xfhA-2hxgA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_A_SPMA501_1
(SPERMINE SYNTHASE)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 ASP A 223
VAL A 226
ASN A 227
ASP A 231
GLU A 255
 None
 1.39A 3c6mA-2hxgA:
undetectable		 3c6mA-2hxgA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_C_SPMC501_1
(SPERMINE SYNTHASE)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 10 ASP A 223
VAL A 226
ASN A 227
ASP A 231
GLU A 255
 None
 1.35A 3c6mC-2hxgA:
undetectable		 3c6mC-2hxgA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		4 / 6 ALA A 313
ILE A 317
LEU A 176
ALA A 198
 None
 0.91A 3r9sA-2hxgA:
3.6		 3r9sA-2hxgA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		4 / 6 ALA A 313
ILE A 317
LEU A 176
ALA A 198
 None
 0.88A 3r9sC-2hxgA:
3.5		 3r9sC-2hxgA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		3 / 3 ARG A 404
TRP A 442
GLY A 447
 None
 1.01A 4e7cA-2hxgA:
undetectable		 4e7cA-2hxgA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 12 PHE A  11
VAL A   9
THR A 126
SER A  84
GLY A 130
 None
 1.35A 4hvcA-2hxgA:
6.4		 4hvcA-2hxgA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 12 PHE A  11
VAL A   9
THR A 126
SER A  84
GLY A 130
 None
 1.41A 4olfA-2hxgA:
5.7		 4olfA-2hxgA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.35A 4qvlV-2hxgA:
undetectable
4qvlb-2hxgA:
undetectable		 4qvlV-2hxgA:
19.59
4qvlb-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.35A 4qvlH-2hxgA:
undetectable
4qvlN-2hxgA:
undetectable		 4qvlH-2hxgA:
19.59
4qvlN-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.36A 4qvmV-2hxgA:
undetectable
4qvmb-2hxgA:
undetectable		 4qvmV-2hxgA:
19.59
4qvmb-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.37A 4qvmH-2hxgA:
undetectable
4qvmN-2hxgA:
undetectable		 4qvmH-2hxgA:
19.59
4qvmN-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.39A 4qvpV-2hxgA:
undetectable
4qvpb-2hxgA:
undetectable		 4qvpV-2hxgA:
19.59
4qvpb-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.40A 4qvpH-2hxgA:
undetectable
4qvpN-2hxgA:
undetectable		 4qvpH-2hxgA:
19.59
4qvpN-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.40A 4qvqV-2hxgA:
undetectable
4qvqb-2hxgA:
undetectable		 4qvqV-2hxgA:
19.59
4qvqb-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.40A 4qvqH-2hxgA:
undetectable
4qvqN-2hxgA:
undetectable		 4qvqH-2hxgA:
19.59
4qvqN-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.36A 4qvwV-2hxgA:
undetectable
4qvwb-2hxgA:
undetectable		 4qvwV-2hxgA:
19.59
4qvwb-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.35A 4qvwH-2hxgA:
undetectable
4qvwN-2hxgA:
undetectable		 4qvwH-2hxgA:
19.59
4qvwN-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.37A 4qw0V-2hxgA:
undetectable
4qw0b-2hxgA:
undetectable		 4qw0V-2hxgA:
19.59
4qw0b-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.36A 4qw0H-2hxgA:
undetectable
4qw0N-2hxgA:
undetectable		 4qw0H-2hxgA:
19.59
4qw0N-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.35A 4qw1V-2hxgA:
undetectable
4qw1b-2hxgA:
undetectable		 4qw1V-2hxgA:
19.59
4qw1b-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.36A 4qw1H-2hxgA:
undetectable
4qw1N-2hxgA:
undetectable		 4qw1H-2hxgA:
19.59
4qw1N-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.38A 4qw3V-2hxgA:
undetectable
4qw3b-2hxgA:
undetectable		 4qw3V-2hxgA:
19.59
4qw3b-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.38A 4qw3H-2hxgA:
undetectable
4qw3N-2hxgA:
undetectable		 4qw3H-2hxgA:
19.59
4qw3N-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.41A 4qwuV-2hxgA:
undetectable
4qwub-2hxgA:
undetectable		 4qwuV-2hxgA:
19.59
4qwub-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.41A 4qwuH-2hxgA:
undetectable
4qwuN-2hxgA:
undetectable		 4qwuH-2hxgA:
19.59
4qwuN-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		3 / 3 ARG A 250
GLN A 244
GLU A 234
 None
 0.79A 4tvtA-2hxgA:
undetectable		 4tvtA-2hxgA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		3 / 3 THR A 451
HIS A 338
LEU A 428
 None
 0.82A 5axdC-2hxgA:
undetectable		 5axdC-2hxgA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 7 LEU A 296
GLN A 294
PHE A 303
PHE A 275
LEU A 267
 None
 1.42A 5b1aC-2hxgA:
undetectable
5b1aJ-2hxgA:
undetectable		 5b1aC-2hxgA:
20.04
5b1aJ-2hxgA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 7 LEU A 296
GLN A 294
PHE A 303
PHE A 275
LEU A 267
 None
 1.40A 5b1aP-2hxgA:
undetectable
5b1aW-2hxgA:
undetectable		 5b1aP-2hxgA:
20.04
5b1aW-2hxgA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 7 LEU A 296
GLN A 294
PHE A 303
PHE A 275
LEU A 267
 None
 1.42A 5b3sC-2hxgA:
undetectable
5b3sJ-2hxgA:
undetectable		 5b3sC-2hxgA:
20.04
5b3sJ-2hxgA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 7 LEU A 296
GLN A 294
PHE A 303
PHE A 275
LEU A 267
 None
 1.42A 5b3sP-2hxgA:
undetectable		 5b3sP-2hxgA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.34A 5bxnV-2hxgA:
undetectable
5bxnb-2hxgA:
undetectable		 5bxnV-2hxgA:
19.59
5bxnb-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.37A 5bxnH-2hxgA:
undetectable
5bxnN-2hxgA:
undetectable		 5bxnH-2hxgA:
19.59
5bxnN-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.39A 5cz7H-2hxgA:
undetectable
5cz7N-2hxgA:
undetectable		 5cz7H-2hxgA:
19.59
5cz7N-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.35A 5d0xV-2hxgA:
undetectable
5d0xb-2hxgA:
undetectable		 5d0xV-2hxgA:
19.59
5d0xb-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.36A 5d0xH-2hxgA:
undetectable
5d0xN-2hxgA:
undetectable		 5d0xH-2hxgA:
19.59
5d0xN-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 7 LEU A 296
GLN A 294
PHE A 303
PHE A 275
LEU A 267
 None
 1.45A 5iy5C-2hxgA:
undetectable
5iy5J-2hxgA:
undetectable		 5iy5C-2hxgA:
20.29
5iy5J-2hxgA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 12 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.35A 5l5zV-2hxgA:
undetectable
5l5zb-2hxgA:
undetectable		 5l5zV-2hxgA:
19.59
5l5zb-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.35A 5l66V-2hxgA:
undetectable
5l66b-2hxgA:
undetectable		 5l66V-2hxgA:
19.59
5l66b-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 HIS A 450
THR A 276
THR A 277
GLY A 302
ALA A 312
 MN  A 501 (-3.6A)
None
None
None
None
 1.35A 5l66H-2hxgA:
undetectable
5l66N-2hxgA:
undetectable		 5l66H-2hxgA:
19.59
5l66N-2hxgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 12 GLY A 302
PHE A 275
LEU A 352
PHE A 303
THR A 277
 None
 1.29A 5nknA-2hxgA:
0.0		 5nknA-2hxgA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 12 PHE A  11
VAL A   9
THR A 126
SER A  84
GLY A 130
 None
 1.47A 5xioA-2hxgA:
2.5		 5xioA-2hxgA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		5 / 7 LEU A 296
GLN A 294
PHE A 303
PHE A 275
LEU A 267
 None
 1.42A 5z84C-2hxgA:
undetectable
5z84J-2hxgA:
undetectable		 5z84C-2hxgA:
20.04
5z84J-2hxgA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2hxg L-ARABINOSE
ISOMERASE
(Escherichia
coli) 		4 / 8 TYR A 233
ALA A 292
VAL A 293
ARG A 295
 None
 0.76A 6hu9a-2hxgA:
undetectable
6hu9e-2hxgA:
undetectable		 6hu9a-2hxgA:
23.35
6hu9e-2hxgA:
14.66