SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hxo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 ILE A  20
ALA A  23
ALA A  24
LEU A  36
LEU A  45
 None
 0.94A 1fm9A-2hxoA:
undetectable		 1fm9A-2hxoA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 ILE A  20
ALA A  23
ALA A  24
LEU A  36
LEU A  45
 None
 0.94A 1k74A-2hxoA:
undetectable		 1k74A-2hxoA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 PHE A 217
LEU A 218
ALA A 219
VAL A  75
LEU A 131
 None
 1.07A 1xdkA-2hxoA:
undetectable		 1xdkA-2hxoA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 ILE A  20
ALA A  23
ALA A  24
LEU A  36
LEU A  45
 None
 0.89A 1xlsA-2hxoA:
undetectable		 1xlsA-2hxoA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 ILE A  20
ALA A  23
ALA A  24
LEU A  36
LEU A  45
 None
 0.88A 1xlsB-2hxoA:
undetectable		 1xlsB-2hxoA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 ILE A  20
ALA A  23
ALA A  24
LEU A  36
LEU A  45
 None
 0.89A 1xlsC-2hxoA:
undetectable		 1xlsC-2hxoA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 ILE A  20
ALA A  23
ALA A  24
LEU A  36
LEU A  45
 None
 0.89A 1xlsD-2hxoA:
undetectable		 1xlsD-2hxoA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 ILE A  20
ALA A  23
ALA A  24
LEU A  36
LEU A  45
 None
 0.97A 2aclG-2hxoA:
undetectable		 2aclG-2hxoA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 10 ALA A  66
LEU A  45
LEU A  41
LEU A  62
ARG A  19
 None
 1.27A 2ceoB-2hxoA:
undetectable		 2ceoB-2hxoA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 8 MET A 153
LEU A 157
VAL A  75
GLY A  96
 None
 0.96A 2po5A-2hxoA:
undetectable		 2po5A-2hxoA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 8 MET A 153
LEU A 157
VAL A  75
GLY A  96
 None
 1.02A 2qd5A-2hxoA:
undetectable		 2qd5A-2hxoA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 8 MET A 153
LEU A 157
VAL A  75
GLY A  96
 None
 0.99A 2qd5B-2hxoA:
undetectable		 2qd5B-2hxoA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 10 ALA A  66
LEU A  45
LEU A  41
LEU A  62
ARG A  19
 None
 1.15A 2riwA-2hxoA:
undetectable
2riwB-2hxoA:
undetectable		 2riwA-2hxoA:
21.30
2riwB-2hxoA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 10 ALA A  66
LEU A  45
LEU A  41
LEU A  62
ARG A  19
 None
 1.16A 2xn6A-2hxoA:
undetectable
2xn6B-2hxoA:
undetectable		 2xn6A-2hxoA:
20.64
2xn6B-2hxoA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 10 ALA A  66
LEU A  45
LEU A  41
LEU A  62
ARG A  19
 None
 1.16A 2xn7A-2hxoA:
undetectable
2xn7B-2hxoA:
undetectable		 2xn7A-2hxoA:
20.93
2xn7B-2hxoA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 LEU A 152
LEU A  97
ILE A 127
ALA A  89
ALA A  94
 None
 0.99A 3mdvB-2hxoA:
undetectable		 3mdvB-2hxoA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 ALA A 100
GLN A 114
GLY A 121
 None
 0.57A 4odoC-2hxoA:
undetectable		 4odoC-2hxoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 9 ALA A  73
THR A  72
ALA A  69
GLY A  96
ALA A 100
 None
 1.21A 4qvnK-2hxoA:
undetectable
4qvnL-2hxoA:
undetectable		 4qvnK-2hxoA:
18.26
4qvnL-2hxoA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 9 ALA A  73
THR A  72
ALA A  69
GLY A  96
ALA A 100
 None
 1.22A 4qvnY-2hxoA:
undetectable
4qvnZ-2hxoA:
undetectable		 4qvnY-2hxoA:
18.26
4qvnZ-2hxoA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 10 ASP A  68
VAL A 123
LEU A 107
THR A 101
ALA A 100
 None
 1.50A 4yhaB-2hxoA:
undetectable		 4yhaB-2hxoA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 11 PHE A 217
LEU A 218
ALA A 219
VAL A  75
LEU A 131
 None
 1.08A 5ji0A-2hxoA:
undetectable		 5ji0A-2hxoA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 ILE A  20
ALA A  23
ALA A  24
LEU A  36
LEU A  45
 None
 0.98A 5z12B-2hxoA:
undetectable		 5z12B-2hxoA:
20.09