SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hxr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR
(Escherichia
coli) 		3 / 3 THR A 100
THR A 102
PRO A  99
 None
 0.84A 1dscC-2hxrA:
undetectable		 1dscC-2hxrA:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR
(Escherichia
coli) 		5 / 9 LEU A 267
VAL A  97
GLY A 107
VAL A 143
ILE A 145
 None
 0.91A 1ohrB-2hxrA:
undetectable		 1ohrB-2hxrA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR
(Escherichia
coli) 		5 / 12 VAL A 227
SER A 223
SER A 103
VAL A 168
LEU A 165
 None
 1.47A 1rk3A-2hxrA:
undetectable		 1rk3A-2hxrA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR
(Escherichia
coli) 		5 / 11 GLY A 144
ALA A 146
ALA A 265
LEU A 160
VAL A 150
 None
 1.02A 1ukbA-2hxrA:
undetectable		 1ukbA-2hxrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR
(Escherichia
coli) 		3 / 3 THR A 100
THR A 102
PRO A  99
 None
 0.86A 1unmF-2hxrA:
undetectable		 1unmF-2hxrA:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR
(Escherichia
coli) 		5 / 12 LEU A 160
ILE A 145
PHE A 105
ASP A 112
PHE A 282
 None
 1.20A 1zz1B-2hxrA:
undetectable
1zz1C-2hxrA:
undetectable		 1zz1B-2hxrA:
22.02
1zz1C-2hxrA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR
(Escherichia
coli) 		5 / 12 ILE A 224
ALA A 226
LEU A 230
ILE A 231
LEU A 194
 None
 0.96A 2aclG-2hxrA:
undetectable		 2aclG-2hxrA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR
(Escherichia
coli) 		4 / 5 ASP A 142
LEU A 141
MET A 135
ARG A  94
 None
 1.31A 2gj5A-2hxrA:
undetectable		 2gj5A-2hxrA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR
(Escherichia
coli) 		3 / 3 LEU A  93
LEU A 267
PHE A 113
 None
 0.73A 2pgrA-2hxrA:
undetectable		 2pgrA-2hxrA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR
(Escherichia
coli) 		5 / 8 THR A 200
LEU A 194
VAL A 227
LEU A 165
VAL A 168
 None
 1.11A 2zujA-2hxrA:
undetectable		 2zujA-2hxrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR
(Escherichia
coli) 		6 / 12 ILE A 132
LEU A 268
LEU A 155
THR A 200
VAL A 150
PRO A  99
 None
 1.42A 3dcjA-2hxrA:
undetectable
3dcjB-2hxrA:
undetectable		 3dcjA-2hxrA:
24.12
3dcjB-2hxrA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR
(Escherichia
coli) 		4 / 7 LEU A 240
VAL A 168
VAL A 227
LEU A 175
 None
 0.77A 3rgfA-2hxrA:
undetectable		 3rgfA-2hxrA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR
(Escherichia
coli) 		4 / 8 ALA A 243
PHE A 147
PHE A 101
THR A 200
 None
 0.97A 3t3sF-2hxrA:
undetectable		 3t3sF-2hxrA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		 2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR
(Escherichia
coli) 		5 / 10 LEU A 141
LEU A 155
MET A 127
GLU A 130
VAL A  97
 None
 1.43A 3ua5B-2hxrA:
0.0		 3ua5B-2hxrA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR
(Escherichia
coli) 		5 / 12 VAL A 227
SER A 223
SER A 103
VAL A 168
LEU A 165
 None
 1.49A 3vt3A-2hxrA:
undetectable		 3vt3A-2hxrA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR
(Escherichia
coli) 		5 / 12 VAL A 227
SER A 223
SER A 103
VAL A 168
LEU A 165
 None
 1.50A 3vt7A-2hxrA:
undetectable		 3vt7A-2hxrA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR
(Escherichia
coli) 		5 / 11 LEU A 267
VAL A  97
GLY A 107
VAL A 143
ILE A 145
 None
 0.94A 4qgiB-2hxrA:
undetectable		 4qgiB-2hxrA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR
(Escherichia
coli) 		3 / 3 CYH A 208
LYS A 210
HIS A 206
 None
 1.19A 5js5A-2hxrA:
undetectable		 5js5A-2hxrA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR
(Escherichia
coli) 		5 / 10 MET A 285
ALA A 286
THR A 162
PHE A 105
PHE A 101
 None
 1.33A 6hu9C-2hxrA:
undetectable		 6hu9C-2hxrA:
21.52