SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hxs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 2hxs RAS-RELATED PROTEIN
RAB-28
(Homo
sapiens) 		5 / 10 LEU A  64
ALA A 125
VAL A  62
LEU A 178
PHE A  32
 None
 1.15A 1rlbE-2hxsA:
undetectable		 1rlbE-2hxsA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 2hxs RAS-RELATED PROTEIN
RAB-28
(Homo
sapiens) 		5 / 11 VAL A  17
LEU A  18
GLY A  19
SER A 100
LYS A 143
 None
 1.36A 3bjwE-2hxsA:
undetectable		 3bjwE-2hxsA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2hxs RAS-RELATED PROTEIN
RAB-28
(Homo
sapiens) 		3 / 3 GLY A  85
TRP A  67
VAL A  16
 None
 0.76A 3n62B-2hxsA:
undetectable		 3n62B-2hxsA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2hxs RAS-RELATED PROTEIN
RAB-28
(Homo
sapiens) 		3 / 3 GLY A  85
TRP A  67
VAL A  16
 None
 0.77A 3n65B-2hxsA:
undetectable		 3n65B-2hxsA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2hxs RAS-RELATED PROTEIN
RAB-28
(Homo
sapiens) 		3 / 3 GLY A  85
TRP A  67
VAL A  16
 None
 0.77A 3n66B-2hxsA:
1.2		 3n66B-2hxsA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2hxs RAS-RELATED PROTEIN
RAB-28
(Homo
sapiens) 		3 / 3 SER A 155
ALA A 125
VAL A 124
 None
 0.65A 4o2bC-2hxsA:
4.9		 4o2bC-2hxsA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2hxs RAS-RELATED PROTEIN
RAB-28
(Homo
sapiens) 		4 / 8 ALA A 125
GLY A  88
LEU A 123
LYS A 172
 None
 0.88A 4po0A-2hxsA:
undetectable		 4po0A-2hxsA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 2hxs RAS-RELATED PROTEIN
RAB-28
(Homo
sapiens) 		4 / 7 ASP A  68
ILE A  69
GLY A  19
THR A  26
 MG  A 402 ( 4.0A)
None
None
MG  A 402 ( 3.0A)
 1.01A 4zxiA-2hxsA:
2.9		 4zxiA-2hxsA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2hxs RAS-RELATED PROTEIN
RAB-28
(Homo
sapiens) 		5 / 9 LEU A  28
THR A  26
GLY A  70
ILE A  69
PHE A 170
 None
MG  A 402 ( 3.0A)
MG  A 402 ( 4.5A)
None
None
 1.34A 6ebpA-2hxsA:
undetectable		 6ebpA-2hxsA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2hxs RAS-RELATED PROTEIN
RAB-28
(Homo
sapiens) 		5 / 9 LEU A  28
THR A  26
GLY A  70
PHE A 170
ILE A  66
 None
MG  A 402 ( 3.0A)
MG  A 402 ( 4.5A)
None
None
 1.26A 6ebpA-2hxsA:
undetectable		 6ebpA-2hxsA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 2hxs RAS-RELATED PROTEIN
RAB-28
(Homo
sapiens) 		3 / 3 LEU A 126
SER A 154
PHE A 153
 None
 0.67A 6fgcA-2hxsA:
undetectable		 6fgcA-2hxsA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 2hxs RAS-RELATED PROTEIN
RAB-28
(Homo
sapiens) 		4 / 8 ALA A 125
GLY A  88
LEU A 123
LYS A 172
 None
 0.83A 6mdqA-2hxsA:
undetectable		 6mdqA-2hxsA:
19.19