SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hxv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		5 / 12 GLU A  75
ASP A  88
HIS A  80
GLY A 110
PHE A 116
 None
GOL  A 509 (-3.4A)
None
None
None
 1.35A 1d4fB-2hxvA:
undetectable		 1d4fB-2hxvA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		4 / 5 LEU A 204
THR A 205
ARG A 216
VAL A 197
 CL  A 501 (-4.9A)
None
None
None
 1.09A 1ekjF-2hxvA:
undetectable
1ekjG-2hxvA:
undetectable		 1ekjF-2hxvA:
21.88
1ekjG-2hxvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		5 / 11 ILE A  37
GLY A  27
ALA A   9
GLY A 101
ILE A 100
 None
 0.97A 2fxdA-2hxvA:
undetectable		 2fxdA-2hxvA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_A_ADNA901_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		5 / 10 HIS A 253
PHE A 233
ASN A 236
ALA A 237
VAL A 197
 None
 1.12A 2gl0A-2hxvA:
0.0
2gl0B-2hxvA:
0.0		 2gl0A-2hxvA:
20.88
2gl0B-2hxvA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		5 / 11 HIS A 253
PHE A 233
ASN A 236
ALA A 237
VAL A 197
 None
 1.07A 2gl0B-2hxvA:
undetectable
2gl0C-2hxvA:
undetectable		 2gl0B-2hxvA:
20.88
2gl0C-2hxvA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		5 / 11 HIS A 253
PHE A 233
ASN A 236
ALA A 237
VAL A 197
 None
 1.07A 2gl0E-2hxvA:
undetectable
2gl0F-2hxvA:
undetectable		 2gl0E-2hxvA:
20.88
2gl0F-2hxvA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_F_ADNF906_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		5 / 11 ASN A 236
ALA A 237
VAL A 197
HIS A 253
PHE A 233
 None
 1.07A 2gl0D-2hxvA:
undetectable
2gl0F-2hxvA:
undetectable		 2gl0D-2hxvA:
20.88
2gl0F-2hxvA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ILE A 162
GLY A 193
GLY A 282
VAL A 190
VAL A 197
 NDP  A 400 (-3.8A)
NDP  A 400 (-3.5A)
NDP  A 400 ( 3.8A)
None
None
 0.88A 2yvlA-2hxvA:
undetectable		 2yvlA-2hxvA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ILE A 162
GLY A 193
GLY A 282
VAL A 190
VAL A 197
 NDP  A 400 (-3.8A)
NDP  A 400 (-3.5A)
NDP  A 400 ( 3.8A)
None
None
 0.90A 2yvlB-2hxvA:
undetectable		 2yvlB-2hxvA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		4 / 6 PHE A  41
GLY A  27
LEU A 135
PRO A  25
 None
 0.93A 3bgdA-2hxvA:
undetectable		 3bgdA-2hxvA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		5 / 12 PRO A 202
THR A 196
SER A 288
ILE A 266
LEU A 191
 GOL  A 505 ( 4.6A)
NDP  A 400 (-3.2A)
None
None
None
 1.23A 3iv6C-2hxvA:
undetectable		 3iv6C-2hxvA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		5 / 9 HIS A  49
VAL A  26
LEU A 135
PHE A 139
VAL A 143
 ZN  A 500 (-3.2A)
None
None
None
None
 1.26A 3jwqA-2hxvA:
undetectable		 3jwqA-2hxvA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A  49
LEU A  17
PHE A 139
VAL A 143
 ZN  A 500 (-3.2A)
None
None
None
 1.07A 3jwqC-2hxvA:
undetectable		 3jwqC-2hxvA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		3 / 3 GLU A  39
LEU A  12
LEU A 128
 None
 0.62A 3ohtA-2hxvA:
undetectable		 3ohtA-2hxvA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		3 / 3 GLU A  39
LEU A  12
LEU A 128
 None
 0.61A 3ohtB-2hxvA:
undetectable		 3ohtB-2hxvA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		4 / 7 PHE A 290
VAL A 278
ILE A 275
GLU A 289
 None
None
None
NDP  A 400 (-2.9A)
 1.14A 4a97E-2hxvA:
undetectable		 4a97E-2hxvA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		4 / 6 SER A 169
THR A 173
ILE A 172
THR A 196
 NDP  A 400 ( 2.6A)
GOL  A 503 (-4.2A)
GOL  A 503 (-4.0A)
NDP  A 400 (-3.2A)
 0.79A 4acbC-2hxvA:
undetectable		 4acbC-2hxvA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		4 / 5 VAL A 286
LEU A 191
VAL A 278
PHE A 290
 NDP  A 400 (-4.0A)
None
None
None
 1.00A 4lb0B-2hxvA:
undetectable		 4lb0B-2hxvA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		3 / 3 ILE A 266
ASP A 260
ARG A 273
 None
 0.79A 4pstA-2hxvA:
undetectable		 4pstA-2hxvA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		3 / 3 LEU A 291
VAL A 150
ASP A 295
 None
None
GOL  A 504 (-3.9A)
 0.57A 4y8wC-2hxvA:
undetectable		 4y8wC-2hxvA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		4 / 6 PHE A 233
GLY A 227
TYR A 250
ALA A 248
 None
 0.96A 4yshB-2hxvA:
undetectable		 4yshB-2hxvA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		5 / 9 VAL A 278
VAL A 280
PHE A 290
PHE A 242
LEU A 270
 None
 1.36A 5e4dA-2hxvA:
0.0		 5e4dA-2hxvA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		5 / 10 GLY A 112
GLY A 110
GLU A  75
ASP A 104
ILE A  90
 None
 1.20A 6exiA-2hxvA:
undetectable		 6exiA-2hxvA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		5 / 10 GLY A 112
GLY A 110
GLU A  75
ASP A 104
ILE A  90
 None
 1.19A 6exiB-2hxvA:
undetectable		 6exiB-2hxvA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_0
(ADENOSYLHOMOCYSTEINA
SE)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		5 / 12 HIS A  49
ASP A 104
ASN A 106
HIS A  79
ASN A  23
 ZN  A 500 (-3.2A)
None
None
None
None
 1.34A 6exiC-2hxvA:
undetectable		 6exiC-2hxvA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		5 / 12 GLY A 112
GLY A 110
GLU A  75
ASP A 104
ILE A  90
 None
 1.18A 6exiC-2hxvA:
undetectable
6exiD-2hxvA:
undetectable		 6exiC-2hxvA:
16.04
6exiD-2hxvA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE
(Thermotoga
maritima) 		5 / 12 GLY A 112
GLY A 110
GLU A  75
ASP A 104
ILE A  90
 None
 1.20A 6exiC-2hxvA:
undetectable
6exiD-2hxvA:
undetectable		 6exiC-2hxvA:
16.04
6exiD-2hxvA:
16.04