SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hy5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2hy5 INTRACELLULAR SULFUR
OXIDATION PROTEIN
DSRF
(Allochromatium
vinosum) 		5 / 12 LEU B 242
LEU B 251
ILE B 318
SER B 286
LEU B 287
 None
 1.01A 1cqeA-2hy5B:
undetectable		 1cqeA-2hy5B:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2hy5 INTRACELLULAR SULFUR
OXIDATION PROTEIN
DSRF
(Allochromatium
vinosum) 		5 / 12 LEU B 242
LEU B 251
ILE B 318
SER B 286
LEU B 287
 None
 1.01A 1cqeB-2hy5B:
undetectable		 1cqeB-2hy5B:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_2
(NEURAMINIDASE N9)		 2hy5 PUTATIVE
SULFURTRANSFERASE
DSRE
(Allochromatium
vinosum) 		4 / 4 ASP A  18
ARG A  63
TRP A  64
ILE A   7
 None
 1.42A 1nncA-2hy5A:
undetectable		 1nncA-2hy5A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2hy5 DSRH
(Allochromatium
vinosum) 		4 / 8 PHE C 471
SER C 472
ALA C 442
LEU C 441
 None
 0.91A 2o01A-2hy5C:
undetectable		 2o01A-2hy5C:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUR_B_TESB340_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 2hy5 PUTATIVE
SULFURTRANSFERASE
DSRE
(Allochromatium
vinosum) 		5 / 10 ILE A  34
SER A  47
ASN A  46
TRP A  64
VAL A  61
 None
 1.31A 3burB-2hy5A:
1.5		 3burB-2hy5A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 2hy5 INTRACELLULAR SULFUR
OXIDATION PROTEIN
DSRF
PUTATIVE
SULFURTRANSFERASE
DSRE
(Allochromatium
vinosum) 		4 / 7 TYR B 275
TYR B 210
PHE B 336
TYR A  40
 None
 1.05A 3ku9B-2hy5B:
undetectable		 3ku9B-2hy5B:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2hy5 INTRACELLULAR SULFUR
OXIDATION PROTEIN
DSRF
(Allochromatium
vinosum) 		5 / 12 LEU B 242
LEU B 251
ILE B 318
SER B 286
LEU B 287
 None
 1.08A 3n8xB-2hy5B:
undetectable		 3n8xB-2hy5B:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 2hy5 INTRACELLULAR SULFUR
OXIDATION PROTEIN
DSRF
(Allochromatium
vinosum) 		4 / 7 ALA B 225
VAL B 241
VAL B 229
LEU B 226
 None
 0.88A 3o14A-2hy5B:
undetectable		 3o14A-2hy5B:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_2
(NEURAMINIDASE)		 2hy5 PUTATIVE
SULFURTRANSFERASE
DSRE
(Allochromatium
vinosum) 		4 / 5 ASP A  18
ARG A  63
TRP A  64
ILE A   7
 None
 1.46A 3sanA-2hy5A:
undetectable		 3sanA-2hy5A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_2
(NEURAMINIDASE)		 2hy5 PUTATIVE
SULFURTRANSFERASE
DSRE
(Allochromatium
vinosum) 		4 / 5 ASP A  18
ARG A  63
TRP A  64
ILE A   7
 None
 1.46A 3sanB-2hy5A:
undetectable		 3sanB-2hy5A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 2hy5 DSRH
PUTATIVE
SULFURTRANSFERASE
DSRE
(Allochromatium
vinosum) 		4 / 5 ARG A  63
TRP A  64
ILE A   7
ASN C 408
 None
 1.25A 4i00A-2hy5A:
undetectable		 4i00A-2hy5A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2hy5 INTRACELLULAR SULFUR
OXIDATION PROTEIN
DSRF
(Allochromatium
vinosum) 		4 / 7 GLU B 306
GLU B 309
GLU B 276
ARG B 278
 None
 0.99A 4mi4B-2hy5B:
undetectable
4mi4C-2hy5B:
undetectable		 4mi4B-2hy5B:
18.32
4mi4C-2hy5B:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2hy5 INTRACELLULAR SULFUR
OXIDATION PROTEIN
DSRF
(Allochromatium
vinosum) 		4 / 8 GLU B 306
GLU B 309
GLU B 276
ARG B 278
 None
 1.01A 4mj8B-2hy5B:
undetectable
4mj8C-2hy5B:
undetectable		 4mj8B-2hy5B:
20.88
4mj8C-2hy5B:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 2hy5 PUTATIVE
SULFURTRANSFERASE
DSRE
(Allochromatium
vinosum) 		5 / 12 TYR A  40
GLY A  86
LEU A 112
LEU A 115
ARG A  36
 None
 1.12A 4wcxC-2hy5A:
2.1		 4wcxC-2hy5A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2hy5 DSRH
(Allochromatium
vinosum) 		5 / 12 GLU C 434
ALA C 440
ALA C 439
VAL C 446
LEU C 441
 None
 1.34A 5igpA-2hy5C:
undetectable		 5igpA-2hy5C:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2hy5 DSRH
(Allochromatium
vinosum) 		5 / 12 THR C 451
ILE C 480
GLY C 479
LEU C 421
LEU C 457
 None
 0.92A 5nfjA-2hy5C:
undetectable		 5nfjA-2hy5C:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2hy5 PUTATIVE
SULFURTRANSFERASE
DSRE
(Allochromatium
vinosum) 		3 / 3 LEU A  28
ALA A  27
LEU A  67
 None
 0.54A 5uunB-2hy5A:
undetectable		 5uunB-2hy5A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 2hy5 INTRACELLULAR SULFUR
OXIDATION PROTEIN
DSRF
PUTATIVE
SULFURTRANSFERASE
DSRE
(Allochromatium
vinosum) 		4 / 5 TYR A  40
GLN A   6
GLY B 218
ILE B 220
 None
 1.46A 6debB-2hy5A:
undetectable		 6debB-2hy5A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 2hy5 PUTATIVE
SULFURTRANSFERASE
DSRE
INTRACELLULAR SULFUR
OXIDATION PROTEIN
DSRF
(Allochromatium
vinosum;
Allochromatium
vinosum) 		5 / 12 PHE A  23
LEU B 211
GLY A 129
PHE A 128
ASN A   8
 None
 1.17A 6r2eE-2hy5A:
undetectable		 6r2eE-2hy5A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 2hy5 PUTATIVE
SULFURTRANSFERASE
DSRE
INTRACELLULAR SULFUR
OXIDATION PROTEIN
DSRF
(Allochromatium
vinosum;
Allochromatium
vinosum) 		5 / 11 PHE A  23
LEU B 211
GLY A 129
PHE A 128
ASN A   8
 None
 1.15A 6r2eG-2hy5A:
undetectable		 6r2eG-2hy5A:
18.27